Ethyl pyruvate

Structural formula
General
Surname	Ethyl pyruvate
other names	Ethyl pyruvate Ethyl 2-oxopropionate ETHYL PYRUVATE ( INCI )
Molecular formula	C 5 H 8 O 3
Brief description	colorless liquid with a pungent odor
External identifiers / databases
CAS number 617-35-6 EC number 210-511-2 ECHA InfoCard 100.009.557 PubChem 12041 ChemSpider 11544 DrugBank DB05869 Wikidata Q15632706
properties
Molar mass	116.12 g mol −1
Physical state	liquid
density	1.05 g cm −3
Melting point	-58 ° C
boiling point	144-146 ° C
solubility	slightly soluble in water (10 g l −1 at 20 ° C)
Refractive index	1.4056
safety instructions
GHS labeling of hazardous substances Caution H and P phrases H: 226 P: 210-235 + 410
Toxicological data	> 2000 mg kg −1 ( LD 50 ,  rat ,  oral ) > 2000 mg kg −1 ( LD 50 ,  rat ,  transdermal )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

Ethyl pyruvate is a chemical compound from the group of pyruvate . It has a cytoprotective effect and acts as an inhibitor of the CO ₂ sensors in the yellow fever mosquito .

Extraction and presentation

Ethyl pyruvate is obtained by oxidizing ethyl lactate with potassium permanganate .

Individual evidence

1. ↑ Entry on ETHYL PYRUVATE in the CosIng database of the EU Commission, accessed on March 17, 2020.
2. ↑ ^{a b c d e f g h} Entry on ethyl pyruvate in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .
3. ↑ ^{a b c} Data sheet 4-ethylpyruvate (PDF) from Merck , accessed on December 17, 2013.
4. ↑ X. Su, H. Wang, L. Zhu, J. Zhao, H. Pan, X. Ji: Ethyl pyruvate ameliorates intracerebral hemorrhage-induced brain injury through anti-cell death and anti-inflammatory mechanisms . In: Neuroscience . tape 245 , 2013, p. 99-108 , doi : 10.1016 / j.neuroscience.2013.04.032 .
5. ↑ Genevieve M. Tauxe, Dyan MacWilliam, Sean Michael Boyle, Tom Guda, Anandasankar Ray: Targeting a Dual Detector of Skin and CO ₂ to Modify Mosquito Host Seeking . In: Cell . tape 155 , no. 6 , 2013, p. 1365-1379 , doi : 10.1016 / j.cell.2013.11.013 ( PDF ).