Cefodizime
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Surname | Cefodizime | ||||||||||||||||||
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Molecular formula | C 20 H 20 N 6 O 7 S 4 | ||||||||||||||||||
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Molar mass | 584.65 g mol −1 | ||||||||||||||||||
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firmly |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Cefodizim is a drug from the group of cephalosporins , more precisely the broad spectrum cephalosporins . It was first patented by Hoechst in 1978 . The antibiotic is used in the form of the disodium salt . It works against both gram-positive and gram-negative bacteria, which is why it is used, for example, to treat streptococci .
properties
Cefodizim comes from the third generation of the cephalosporins and is one of the cefotaxime derivatives. It differs from those of the previous generations in that it has a long elimination time and excellent tissue permeability. In addition, it is not attacked by β-lactamases . The intake of cefodizime proved to be harmless in toxicological studies, and there was also a higher kidney tolerance than other cephalosoprins. No abnormalities with regard to the platelet count , blood coagulation or vitamin K metabolism could be found while taking cefodizime .
use
Cefodizim is suitable for treating infections of the respiratory and urinary tract . A large number of pathogens that are resistant to cefodizime are already known. These include, for example, Staphylococcus epidermidis and Enterococcus faecalis . In addition, a majority of the Pseudomonas and Acinetobacter strains.
Individual evidence
- ↑ a b c data sheet Cefodizime sodium ≥96% (HPLC) from Sigma-Aldrich , accessed on April 8, 2020 ( PDF ).
- ↑ a b c d e f Entry on cefodizim. In: Römpp Online . Georg Thieme Verlag, accessed on April 9, 2020.
- ↑ a b H. Knothe, PM Shah: In vitro activity of cefodizime . In: Infection, 1992, Vol. 20, pp. 3-8, doi : 10.1007 / BF01709942 .
- ^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006, ISBN 978-0-911910-00-1 , pp. 316.
- ^ K. Andrassy: Safety profile of cefodizime . In: Infection, 1992, Vol. 20, pp. 36-40, doi : 10.1007 / BF01709949 .
- ↑ H. Knothe, PM Shah: In vivo activity of cefodizime . In: Infection, 1992, Vol. 20, pp. 9-13, doi : 10.1007 / BF01709943 .