Cefodizime

Structural formula
General
Surname	Cefodizime
other names	(6 R , 7 R ) -7- {2- (2-Amino-4-thiazolyl) -2 - [( Z ) -methoximino] acetamido} -3 - [(5-carboxymethyl-4-methyl-2-thiazolylthio ) methyl] -3-cephem-4-carboxylic acid; (6 R , 7 R ) -7 - {[(2 Z ) - (2-Amino-4-thiazolyl) (methoxyimino) acetyl] amino} -3 - ({[5- (carboxymethyl) -4-methyl-2 -thiazolyl] thio} methyl) -8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-en-2-carboxylic acid;
Molecular formula	C 20 H 20 N 6 O 7 S 4
External identifiers / databases
EC number	700-301-3
ECHA InfoCard	100.148.965
PubChem	5361871
ChemSpider	4514859
Wikidata	Q5057292
Drug information
ATC code	J01 DD09
Drug class	β-lactam antibiotic
Mechanism of action	Inhibition of cell wall synthesis
properties
Molar mass	584.65 g mol −1
Physical state	firmly
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Disodium salt Caution
H and P phrases	H: 319
	P: 305 + 351 + 338
Toxicological data	4–8 g kg −1 ( LD 50 , mouse , iv ) ; 4–8 g kg −1 ( LD 50 , rat , iv ) ; 8–11 g kg −1 ( LD 50 , rat , ip ) ; 15–17.5 g kg −1 ( LD 50 , rat , sc ) ; 4–8 g kg −1 ( LD 50 , rabbit , iv ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Cefodizim is a drug from the group of cephalosporins , more precisely the broad spectrum cephalosporins . It was first patented by Hoechst in 1978 . The antibiotic is used in the form of the disodium salt . It works against both gram-positive and gram-negative bacteria, which is why it is used, for example, to treat streptococci .

properties

Cefodizim comes from the third generation of the cephalosporins and is one of the cefotaxime derivatives. It differs from those of the previous generations in that it has a long elimination time and excellent tissue permeability. In addition, it is not attacked by β-lactamases . The intake of cefodizime proved to be harmless in toxicological studies, and there was also a higher kidney tolerance than other cephalosoprins. No abnormalities with regard to the platelet count , blood coagulation or vitamin K metabolism could be found while taking cefodizime .

use

Cefodizim is suitable for treating infections of the respiratory and urinary tract . A large number of pathogens that are resistant to cefodizime are already known. These include, for example, Staphylococcus epidermidis and Enterococcus faecalis . In addition, a majority of the Pseudomonas and Acinetobacter strains.

Individual evidence

↑ ^a ^b ^c data sheet Cefodizime sodium ≥96% (HPLC) from Sigma-Aldrich , accessed on April 8, 2020 ( PDF ).
↑ ^a ^b ^c ^d ^e ^f Entry on cefodizim. In: Römpp Online . Georg Thieme Verlag, accessed on April 9, 2020.
↑ ^a ^b H. Knothe, PM Shah: In vitro activity of cefodizime . In: Infection, 1992, Vol. 20, pp. 3-8, doi : 10.1007 / BF01709942 .
^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006, ISBN 978-0-911910-00-1 , pp. 316.
^ K. Andrassy: Safety profile of cefodizime . In: Infection, 1992, Vol. 20, pp. 36-40, doi : 10.1007 / BF01709949 .
↑ H. Knothe, PM Shah: In vivo activity of cefodizime . In: Infection, 1992, Vol. 20, pp. 9-13, doi : 10.1007 / BF01709943 .

[Sigma-1] ta sheet Cefodizime sodium ≥96% (HPLC) from Sigma-Aldrich , accessed on April 8, 2020 ( PDF ).

[Römpp-2] ↑ ^a ^b ^c ^d ^e ^f Entry on cefodizim. In: Römpp Online . Georg Thieme Verlag, accessed on April 9, 2020.

[Knothe-3] H. Knothe, PM Shah: In vitro activity of cefodizime . In: Infection, 1992, Vol. 20, pp. 3-8, doi : 10.1007 / BF01709942 .

[MERCK_Index-4] The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006, ISBN 978-0-911910-00-1 , pp. 316.

[5] K. Andrassy: Safety profile of cefodizime . In: Infection, 1992, Vol. 20, pp. 36-40, doi : 10.1007 / BF01709949 .

[6] H. Knothe, PM Shah: In vivo activity of cefodizime . In: Infection, 1992, Vol. 20, pp. 9-13, doi : 10.1007 / BF01709943 .