Dihydrotachysterol

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Structural formula
Structure of dihydrotachysterol
General
Surname Dihydrotachysterol
other names
  • 9,10-secoergosta-5,7,22-trien-3β-ol
  • DHT2
  • (1 S , 3 E , 4 S ) -3 - [(2 E ) -2 - [(1 R , 3a S , 7a R ) -1 - [( E , 2 R , 5 R ) -5,6- dimethylhept-3-en-2-yl] -7a-methyl-2,3,3a, 5,6,7-hexahydro-1 H -inden-4-ylidene] ethylidene] -4-methylcyclohexane-1-ol
Molecular formula C 28 H 46 O
External identifiers / databases
CAS number 67-96-9
EC number 200-672-7
ECHA InfoCard 100,000,611
PubChem 5311071
ChemSpider 4470607
DrugBank DB01070
Wikidata Q155685
Drug information
ATC code

A11 CC02

Drug class

Vitamin D derivative

properties
Molar mass 398.66 g mol −1
Physical state

firmly

Melting point

110–115 (also 125–127 stated) ° C

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
06 - Toxic or very toxic

danger

H and P phrases H: 301
P: 301 + 310
Toxicological data

288 mg kg −1 ( LD 50 ,  mouse ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Dihydrotachysterol (DHT) is in the liver activated synthetic vitamin D - analogue that no renal hydroxylation requires such as vitamin D 2 ( ergocalciferol ) and vitamin D 3 ( cholecalciferol ). DHT has a quick onset of action (2 hours), a shorter half-life and a greater effect on the mineralization of bone salts than vitamin D. It is used in cases of underactive parathyroid glands . The active ingredient was patented by Winthrop in 1941 and is commercially available as a generic .

Trade names

Monopreparations : AT 10 (D, CH)

Individual evidence

  1. ↑ a b c d data sheet Dihydrotachysterol, analytical standard at Sigma-Aldrich , accessed on February 3, 2019 ( PDF ).
  2. ↑ a b Entry on Dihydrotachysterol. In: Römpp Online . Georg Thieme Verlag, accessed on February 3, 2019.
  3. ^ R. Gagnon, GW Ogden, G. Just, M. Kaye: Comparison of Dihydrotachysterol and 5,6-trans Vitamin D 3 on Intestinal Calcium Absorption in Patients with Chronic Renal Failure . In: Canadian Journal of Physiology and Pharmacology . tape 52 , no. 2 , 1974, p. 272-274 , doi : 10.1139 / y74-037 , PMID 4365509 .