Ditalimfos

Structural formula
General
Surname	Ditalimfos
other names	O, O- diethylphthalimidothiophosphonate; Leucon; Frutogard; Laptran; Plondrel; O, O- diethyl- N -phthalimidothiophosphate;
Molecular formula	C 12 H 14 NO 4 PS
External identifiers / databases
EC number	225-875-8
ECHA InfoCard	100.023.523
PubChem	21207
Wikidata	Q15632709
properties
Molar mass	299.29 g mol −1
Physical state	firmly
Melting point	83-84 ° C
solubility	very sparingly soluble in water (0.133 g l −1 at 20 ° C)
safety instructions
GHS hazard labeling from Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary Caution
H and P phrases	H: 315-317
	P: 210-280-305 + 351 + 338
Toxicological data	4930 mg kg −1 ( LD 50 , rat , oral ) ; 1000 mg kg −1 ( LD 50 , rabbit , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Ditalimfos is a chemical compound from the group of thiophosphoric acid esters and phthalimides and a systemic fungicide with a curative effect. Ditalimfos was discovered by Henry Tolkmith in 1966 . It was used against powdery mildew , apple scab and monilinia under the trade names Frutogard and Plondrel . Ditalimfos inhibits the synthesis of phosphatidylcholine .

Extraction and presentation

Ditalimfos can be obtained by reacting potassium phthalimide with O , O -diethylchlorothiophosphate (DEPCT).

Admission

No plant protection products containing this active ingredient are permitted in the EU or Switzerland . Ditalimfos was approved in the FRG from 1973 to 1986.

Individual evidence

↑ ^a ^b ^c ^d Entry on Ditalimfos in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .

↑ Entry on Ditalimfos in the Pesticide Properties DataBase (PPDB) of the University of Hertfordshire , accessed on December 13, 2013.

↑ Entry on O, O-diethyl phthalimidophosphonothioate in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

↑ Ditalimfos solution data sheet at Sigma-Aldrich , accessed on May 21, 2017 ( PDF ).

↑ Gyorgy Matolcsy Miklós Nádasy, Viktor Andriska, Sándor Terényi: Pesticide chemistry . Elsevier, 1989, ISBN 978-0-444-98903-1 , pp. 308 ( limited preview in Google Book search).

↑ Thomas A. Unger: Pesticide Synthesis Handbook . William Andrew, 1996, ISBN 0-8155-1853-6 , pp. 377 ( limited preview in Google Book search).

↑ General Directorate Health and Food Safety of the European Commission: Entry on Ditalimfos in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 26, 2016.

↑ Regulation (EC) No. 2076/2002 of the Commission of November 20, 2002 (PDF) extending the deadline according to Article 8 (2) of Council Directive 91/414 / EEC and on the non-inclusion of certain active substances in Annex I of this Directive and the revocation of the approval of plant protection products with these active substances.

[GESTIS-1] Entry on Ditalimfos in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .

[PPDB-2] Entry on Ditalimfos in the Pesticide Properties DataBase (PPDB) of the University of Hertfordshire , accessed on December 13, 2013.

[CLP_100.023.523-3] Entry on O, O-diethyl phthalimidophosphonothioate in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .