Zelig Eshhar

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Zelig Eshhar (born in Israel in 1941 ) is an Israeli immunologist and professor emeritus at the Weizmann Institute of Science .

Life

Eshhar holds a bachelor's degree in biochemistry and microbiology and a master's degree in biochemistry from the Hebrew University of Jerusalem . He obtained a doctorate ( Ph.D. ) in immunology at the Weizmann Institute for Science in Rechovot .

From 1976 Eshhar was employed at the Weizmann Institute, first as a research assistant in the Department of Chemical Immunology, from 1982 as Associate Professor , from 1994 as Full Professor. His work there was interrupted by sabbaticals : 1983/84 at the DNAX Research Institute for Molecular Biology in Palo Alto , California , and 1991/92 in the surgery department of the National Cancer Institute in Bethesda , Maryland . From 1995 to 1998 and from 2002 to 2005 he headed the Department of Immunology at the Weizmann Institute. In 2011 he was retired there.

Since 2012 he has been head of immune research at the Tel Aviv Sourasky Medical Center and is a visiting professor at the Medical Faculty of Tel Aviv University .

Act

Eshhar is concerned with molecular recognition by the immune system .

He developed a technique that made T cells attack cancer cells . For this purpose, he created chimeric antigen receptors ( chimeric antigen receptors , CAR) by parts of the T-cell receptor with antibodies merged opposite tumor antigens are directed, or with other molecules which allow binding to tumor cells. With this he brought significant progress in the immunological treatment of tumors, the cancer immunotherapy .

Further work is concerned with antigen-specific regulatory T cells , which are to be activated for the treatment of chronic inflammatory bowel diseases using CAR, and with methods that are intended to predict the therapeutic response of prostate cancer .

Awards (selection)

Web links

Individual evidence

  1. ↑ a b Prof. Zelig Eshhar 2017 Laureates of Emet Prize. In: emetprize.org. Accessed December 4, 2017 .
  2. ↑ 2014 Massry Prize recipients noted for work in immunotherapy. University of Southern California press release August 19, 2014
  3. ↑ Proof of the Israel Prize , accessed January 15, 2017
personal data
SURNAME Eshhar, Zelig
BRIEF DESCRIPTION Israeli immunologist and professor emeritus at the Weizmann Institute of Science
DATE OF BIRTH 1941
PLACE OF BIRTH Israel