Steven A. Rosenberg

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Steven A. Rosenberg (2008).
Photo by Rhoda Baer.

Steven Aaron Rosenberg (born August 2, 1940 in New York City ) is an American surgeon and cancer researcher at the National Cancer Institute . Rosenberg is considered a pioneer in cancer immunotherapy .

Life

Rosenberg is the child of Polish-Jewish immigrants. He attended the prestigious Bronx High School of Science . Rosenberg graduated from Johns Hopkins University in Baltimore , Maryland with a bachelor's degree in 1961 and an MD in 1964 with a medical degree. He completed his internship and residency at the Peter Bent Brigham Hospital in Boston , Massachusetts , and in 1968 earned a Ph.D. for his work The Proteins of Erythrocyte Membranes at neighboring Harvard University. in biophysics . He then stayed as a research assistant with John David at Harvard University before moving to the National Institutes of Health (NIH) in Bethesda , Maryland. Since 1974 he has been head of the surgery department there. In 1979 he was appointed professor of surgery at the Uniformed Services University of the Health Sciences in Bethesda. In addition, since 1988 he has been a professor of surgery at George Washington University in Washington, DC

Rosenberg has been married to Alice O'Connell since 1968 and the couple have three daughters.

Act

Rosenberg treated advanced tumor diseases with T lymphocytes that had been modified with interleukin-2 (IL-2) to form lymphokine-activated killer cells ( LAK cells ), and with tumor-infiltrating lymphocytes (tumor-infiltrating lymphocytes, TIL) that were treated with IL- 2 had been stimulated. Together with W. French Anderson , Rosenberg carried out the first successful studies on gene therapy in humans by introducing the gene for tumor necrosis factor (TNF) into TIL. Rosenberg identified numerous tumor antigens that are considered target molecules for the development of a "cancer vaccine".

Rosenberg was spokesman for the medical team that treated colon cancer in 1985 under the then US President Ronald Reagan .

Awards (selection)

Fonts

  • with Vincent T. DeVita , Theodore S. Lawrence (Eds.): Cancer: Principles and Practice of Oncology, 10th edition, Wolters Kluwer Health / Lippincott Williams & Wilkins, 2014.

literature

  • Brian Shmaefsky: Biotechnology 101 . Greenwood Publishing Group, 2006, ISBN 978-0-313-33528-0 , chapter Steven A. Rosenberg , pp. 192 ( limited preview in Google Book search).
  • Lisa Yount: Rosenberg, Steven A. in: A to Z of Biologists, Notable Scientists. New York: Facts On File, Inc., 2003. American History Online. Facts On File, Inc. ( online )

Web links

Individual evidence

  1. ↑ Lauréats du Prix Fondation ARC Léopold Griffuel at the Fondation ARC (fondation-arc.org); accessed on May 16, 2019.
  2. ^ List of Past AABB Award Recipients. In: aabb.org. Retrieved February 19, 2016 .
  3. ^ William B. Coley Award at the Cancer Research Institute (cancerresearch.org); accessed on May 16, 2019.
  4. ↑ The 2012 Keio Medical Science Prize Awardees at Keiō University (keio.ac.jp); Retrieved September 15, 2012
personal data
SURNAME Rosenberg, Steven A.
ALTERNATIVE NAMES Rosenberg, Steven; Rosenberg, Steven Aaron (full name)
BRIEF DESCRIPTION American surgeon and cancer researcher at the National Cancer Institute
DATE OF BIRTH 2nd August 1940
PLACE OF BIRTH New York City