Folpet

Structural formula
General
Surname	Folpet
other names	N - (trichloromethylthio) phthalimide
Molecular formula	C 9 H 4 Cl 3 NO 2 S
Brief description	white to yellowish solid
External identifiers / databases
EC number	205-088-6
ECHA InfoCard	100.004.627
PubChem	8607
Wikidata	Q426485
properties
Molar mass	296.56 g mol −1
Physical state	firmly
density	1.72 g cm −3
Melting point	177 ° C (decomposition)
Vapor pressure	0.0013 Pa (20 ° C)
solubility	practically insoluble in water (1.4 mg l −1 at 20 ° C); soluble in chloroform (87 g l −1 ), benzene (22 g l −1 ) and isopropanol (12.5 g l −1 );
safety instructions
H and P phrases	H: 332-317-319-351-400
	P: 261-273-280-304 + 340 + 312-333 + 313-337 + 313
Toxicological data	2640 mg kg −1 ( LD 50 , rat , oral ) ; 22600 mg kg −1 ( LD 50 , rabbit , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Folpet is an active ingredient for crop protection and a chemical compound from the group of phthalimides , sulfenamides and organic chlorine compounds .

Extraction and presentation

Folpet can be made by reacting perchloromethyl mercaptan with the sodium salt of phthalimide in a cold aqueous system or by reacting potassium phthalimide with trichloromethanesulfenyl chloride in organic solvents.

properties

Folpet is a flammable, non-volatile, white to yellowish solid, which is practically insoluble in water.

Use and approval

Folpet is used as a fungicide in crop protection products. In Germany, Austria and Switzerland, plant protection products with this active ingredient are approved, mostly against fungal diseases in viticulture (e.g. folpan ).

Folpet is in the EU since 2015 as a biocide of PT6 admitted. It is used, for example, to preserve colors. It has also been approved for product types 7 (coating protection agents) and 9 (protection agents for fibers, leather, rubber and polymerized materials).

Folpet is believed to be carcinogenic . For reasons of user safety (inhalation of dust when filling) the approval was not extended in 1986 and Folpet was only approved again as water-dispersible granulate (WDG) much later .

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j Entry on Folpet in the GESTIS substance database of the IFA , accessed on January 9, 2019(JavaScript required) .
↑ Donald Mackay, Wan Ying Shiu, Kuo-Ching Ma, Sum Chi Lee: Handbook of physical-chemical properties and environmental fate for organic chemicals , Vol. IV, 2nd Edition, CRC Press, 2006, ISBN 978-1-56670-687 -2 , p. 4065.
↑ ^a ^b Entry on Folpet in the Hazardous Substances Data Bank , accessed July 27, 2012.
↑ Entry on N- (trichloromethylthio) phthalimide in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ General Directorate Health and Food Safety of the European Commission: Entry on Folpet in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 12, 2016.
↑ Implementing Regulation (EU) 2015/1757 of the Commission of September 28, 2015 for the approval of Folpet as an active ingredient for use in biocidal products of product type 6
↑ Implementing Regulation (EU) 2015/1758 of the Commission of 28 September 2015 for the approval of Folpet as an old active substance for use in biocidal products of product types 7 and 9
↑ Answer of the Federal Government to the minor question from Ms. Hönes, Werner (Dierstorf) and the DIE GRÜNEN parliamentary group - printed matter 10/5953 - non- renewal of the approval of 36 plant protection products with the active ingredients Captan, Captafol and Folpet (22 September 1986).

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j Entry on Folpet in the GESTIS substance database of the IFA , accessed on January 9, 2019(JavaScript required) .

[Handbook1-2] Donald Mackay, Wan Ying Shiu, Kuo-Ching Ma, Sum Chi Lee: Handbook of physical-chemical properties and environmental fate for organic chemicals , Vol. IV, 2nd Edition, CRC Press, 2006, ISBN 978-1-56670-687 -2 , p. 4065.

[hsdb-3] Entry on Folpet in the Hazardous Substances Data Bank , accessed July 27, 2012.

[CLP_100.004.627-4] Entry on N- (trichloromethylthio) phthalimide in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[PSM-5] General Directorate Health and Food Safety of the European Commission: Entry on Folpet in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 12, 2016.

[6] Implementing Regulation (EU) 2015/1757 of the Commission of September 28, 2015 for the approval of Folpet as an active ingredient for use in biocidal products of product type 6

[7] Implementing Regulation (EU) 2015/1758 of the Commission of 28 September 2015 for the approval of Folpet as an old active substance for use in biocidal products of product types 7 and 9

[8] Answer of the Federal Government to the minor question from Ms. Hönes, Werner (Dierstorf) and the DIE GRÜNEN parliamentary group - printed matter 10/5953 - non- renewal of the approval of 36 plant protection products with the active ingredients Captan, Captafol and Folpet (22 September 1986).