Heiko Braak

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Prof. Braak at the award of the Great Federal Cross of Merit (2018)

Heiko Braak (born June 16, 1937 in Kiel ) is a German anatomist with a research focus on clinical neuroanatomy . From 1980 to 2002 he held a chair for anatomy at the University of Frankfurt am Main. Subsequently, he worked on a voluntary basis in Frankfurt with issues relating to neurodegenerative diseases in humans. Since 2009 he has been a senior professor at the Center for Biomedical Research at Ulm University.

family

Braak's parents are Elisabeth Braak geb. Möller (1905–1976) and Johannes Edmund “Ivo” Braak (1906–1991), professor of German and Low German philology at the University of Education in Flensburg (1948–1959) and Kiel (1959–1973, rector 1961–1967). The stage director Kai Braak is a brother of Heiko Braak. Braak was married from 1973–2000 to Prof. Dr. rer. nat. Eva Braak b. Foh (1939-2000). From 1967 to 1971 she was an assistant at the Cecile & Oskar Vogt Institute for Brain Research in Neustadt (Black Forest), moved to the Anatomical Institute of the University of Kiel and, since 1980, worked together with Braak at the Center of Morphology at the University of Frankfurt. Widower since 2000, Braak married Dr. med. Dr. phil. Kelly Del Tredici (* 1951 in San Francisco). She came to Germany from Harvard University in 1989 on a Fredrick Sheldon fellowship . She and her husband have been researching at the University of Ulm in the Center for Biomedical Research since 2009 .

Life

Braak studied medicine from 1957 at the University of Hamburg , the Christian-Albrechts-Universität zu Kiel and the Free University of Berlin . He was a medical assistant in Kiel, Stuttgart, Gevelsberg (1963–1965). With a dissertation on the central nervous system of the cartilaginous fish , he was in 1964 in Kiel for Dr. med. PhD. Approved in 1965 , he went to Wolfgang Bargmann at the Anatomical Institute of Kiel University as a research assistant . He completed his habilitation in 1970 and received the venia legendi (habilitation) for the overall subject of anatomy. After four years as a private lecturer , he was appointed associate professor in 1974. In the 1978 summer semester he was visiting professor of neurology at Harvard Medical School . Back in Kiel, he followed the call of the Johann Wolfgang Goethe University in Frankfurt am Main to its chair for anatomy in 1980 . As a university professor (C4) in the Center of Morphology, Dr. Senckenberg anatomy, he was director of the Institute for Clinical Neuroanatomy for 22 years. 2002 emeritus , he worked in research seven years volunteer at the Institute of Clinical Neuroanatomy. In 2009 he went to the Department of Neurology at Ulm University as a senior professor . Through Manfred Lucha , he received the Great Federal Cross of Merit on November 26, 2018 in the Villa Lindenhof (Herrlingen) .

research

Braak was appointed to the NIA-Reagan Commission's Working Group on Consensus Recommendations for the post-mortem Diagnosis of Alzheimer's Disease (Bethesda, USA) in 1996 . His publications deal with the anatomy of the human nervous system and, based on this, also with age changes and neurodegenerative diseases of this organ system. With the range of methods of an anatomist (such as: making serial sections through entire brain hemispheres) and specially developed techniques (such as: depiction of the lipofuscin pigments and the basophilic substance in 100 µm thick brain sections), it is often possible to look at neuropathological questions in a new light and provide answers to previously to find unresolved issues. Braaks h index is 94.

Publications

Braak deals systematically with the neuroanatomy and the architectonics of the human brain . One focus is the relation to neurology with the substrates of Alzheimer's disease , Parkinson's disease , silver grain disease and amyotrophic lateral sclerosis .

M. Alzheimer's

  • with E. Braak: Neuropathological staging of Alzheimer related changes . Acta Neuropathol. 82: 239-259 (1991).
  • with E. Braak: Frequency of stages of Alzheimer-related lesions in different age categories . Neurobiol. Aging 18 (1997), pp. 351-357.
  • with I. Alafuzoff, T. Arzberger, H. Kretzschmar, K. Del Tredici: Staging of Alzheimer-associated neurofibrillary pathology using paraffin sections and immunocytochemistry . Acta Neuropathol. 112 (2006), pp. 389-404.
  • with DR Thal, E. Ghebremedhin, K. Del Tredici, K .: Stages of the pathologic process in Alzheimer's disease: age categories from 1 to 100 years . J. Neuropathol. Exp. Neurol. 70 (2011), pp. 960-969.
  • with K. Del Tredici: Neuroanatomy and pathology of sporadic Alzheimer's disease . Adv. Anat. Embryol. Cell. Biol. 215 (2015), pp. 1-162.

M. Parkinson

  • with K. Del Tredici, U. Rüb, RAI de Vos, JRE Bohl: Where does Parkinson disease pathology begin in the brain? J. Neuropathol. Exp. Neurol. 61 (2002), pp. 413-426.
  • with K. Del Tredici, U. Rüb, RAI de Vos, ENH Jansen Steur: Staging of brain pathology related to sporadic Parkinson's disease . Neurobiol. Aging 24 (2003), pp. 197-211.
  • with CH Hawkes, K. Del Tredici: Parkinson's disease: a dual hit hypothesis . Neuropathol. Appl. Neurobiol. 33 (2007), pp. 599-614.
  • with K. Del Tredici: Neuroanatomy and pathology of sporadic Parkinson's disease . Adv. Anat. Embryol. Cell. Biol. 201 (2009), pp. 1-119.
  • with K. Del Tredici: Spinal cord lesions in sporadic Parkinson's disease . Acta Neuropathol. 124 (2012), pp. 643-666.

Silver grain disease

  • with E. Braak: Cortical and subcortical argyrophilic grains characterize a disease associated with adult onset dementia . Neuropathol. Appl. Neurobiol. 15 (1989), pp. 13-26.
  • with K. Del Tredici, J. Bohl, H. Bratzke , E. Braak: Pathological changes in the parahippocampal region in select non-Alzheimer's dementias . Ann. NY Acad. Sci. 911 (2000), pp. 221-239.
  • with M. Tolnay: Argyrophilic grain disease , in: DW Dickson, RO Weller (eds): Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders , 2nd ed. ISN Neuropathology Press / Wiley-Blackwell, Oxford 2011, pp. 165-170 .

Amyotrophic Lateral Sclerosis

  • with J. Brettschneider, K. Del Tredici, JB Toledo, JL Robinson, DJ Irwin, M. Grossman, E. Suh, VM Van Deerlin, EM Wood, Y. Baek, L. Kwong, EB Lee, L. Elman, L McCluskey, L. Fang, S. Feldengut, AC Ludolph, VM Lee, JQ Trojanowski: Stages of pTDP-43 pathology in amyotrophic lateral sclerosis . Ann. Neurol. 74 (2013), pp. 20-38.
  • with J. Brettschneider, AC Ludolph, VM Lee, JQ Trojanowski, K. Del Tredici: Amyotrophic lateral sclerosis - a model of corticofugal axonal spread . Nat. Rev. Neurol. 9 (2013), pp. 708-714.
  • with AC Ludolph, M. Neumann, J. Ravits, K. Del Tredici, K .: Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis . Acta Neuropathol. 133 (2017), pp. 79-90.
  • with K. Del Tredici: Anterior cingulate cortex TDP-43 pathology in sporadic amyotrophic lateral sclerosis . J. Neuropathol. Exp. Neurol. (2017), in press. doi : 10.1093 / jnen / nlx104 .

Architectonics of the human brain

  • Architectonics of the Human Telencephalic Cortex . Springer, Berlin 1980, pp. 1-146.
  • Architectonics as seen by lipofuscin stains , in: Jones, EG, Peters, A. (eds.): Cerebral Cortex. Cellular Components of the Cerebral Cortex , Vol I. Plenum Press, New York London 1984, pp. 59-104.
  • with E. Braak: Golgi preparations as a tool in neuropathology with particular reference to investigations of the human telencephalic cortex . Progr. Neurobiol. 25: 93-139 (1985).
  • with E. Braak: Anatomy of the human hypothalamus (chiasmatic and tuberal region) , Progr. Brain Res. 93 (1992), pp. 3-16.
  • with E. Braak, D. Yilmazer, J. Bohl: Functional anatomy of human hippocampal formation and related structures . J. Child Neurol. 11 (1996), pp. 265-275.

Honors

  • 1998: Sixth International Alzheimer's Disease and Related Disorders Award for Pioneering Research Contributions on Alzheimer's Disease (Amsterdam)
  • 2006: Irving S. Cooper Visiting Professor in the Neurosciences for 2006, Mayo Clinic (Rochester, Minnesota, USA)
  • 2008: Dingebauer Prize of the German Society for Neurology (Hamburg)
  • 2009: Elected to the German Academy of Sciences Leopoldina (Halle / Saale)
  • 2014: Robert A. Pritzker Prize for Leadership in Parkinson's Disease Research, Michael J. Fox Foundation (New York City)
  • 2014, 2015, 2016: Thomson Reuters List of Highly Cited Scientists 2014 (Neuroscience & Behavior)
  • 2015: Annemarie Opprecht Parkinson Award, Annemarie Opprecht Foundation (Bern)
  • 2015: European Grand Prix for Research, Foundation for Research on Alzheimer (Paris)
  • 2016: Südwestrundfunk Landesschau February 26, 2016
  • 2016: Hans and Ilse Breuer Foundation - Alzheimer Research Award (Frankfurt am Main)
  • 2017: Clarivate Analytics List of Highly Cited Researchers 2017 (Neuroscience & Behavior)
  • 2017: Parkinson's Foundation (New York City) - James Parkinson Medal (New York City)
  • 2017: German Center for Neurodegenerative Diseases - Hartwig Piepenbrock DZNE Prize (Bonn)
  • 2018: Order of Merit of the Federal Republic of Germany , Great Federal Cross of Merit

literature

Web links

Individual evidence

  1. ↑ Prof. Dr. med. Heiko Braak
  2. ↑ James Parkinson Award for Ulm scientist Prof. Heiko Braak for his contribution to Parkinson research (Ulm University)
  3. ↑ Dissertation: Investigations on the central nervous system of Chimaera monstrosa and Spinax niger .
  4. ↑ The Federal President: Announcement of the awards from November 1, 2018
  5. ↑ Member entry by Prof. Dr. Heiko Braak (with picture) at the German Academy of Sciences Leopoldina , accessed on July 1, 2016.
  6. ^ Robert A. Pritzker Prize 2014
  7. ↑ Heiko Braak, MD, Author of Parkinson's Staging Procedure, Honored with 2014 Robert A. Pritzker Prize
  8. ↑ Publication analysis of the media group Thomson Reuters (Ulm University)
  9. ↑ Annika Bingmann: Senior Professor Heiko Braak honored: 100,000 francs for outstanding Parkinson's research. Ulm University, press release from November 4, 2015 at the Informationsdienst Wissenschaft (idw-online.de), accessed on August 24, 2017.
  10. ↑ Heiko Braak and Kelly Del Tredici-Braak, neuroscientists (SWR)
  11. ↑ Heiko Braak (Hans and Ilse Breuer Foundation)
  12. ↑ 2017 Highly Cited Researchers (clarivate.com)
  13. ↑ Five Ulm researchers among the most cited researchers (idw)
  14. ↑ Award for brain researcher Heiko Braak from Ulm (DZNE) ( Memento of the original from January 1, 2018 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.dzne.de
personal data
SURNAME Braak, Heiko
BRIEF DESCRIPTION German neuroanatomist
DATE OF BIRTH June 16, 1937
PLACE OF BIRTH Kiel