Hexafluoroisopropanol
Structural formula | ||||||||||||||||
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General | ||||||||||||||||
Surname | 1,1,1,3,3,3-hexafluoro-2-propanol | |||||||||||||||
other names |
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Molecular formula | C 3 H 2 F 6 O | |||||||||||||||
Brief description |
colorless liquid |
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External identifiers / databases | ||||||||||||||||
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properties | ||||||||||||||||
Molar mass | 168.04 g mol −1 | |||||||||||||||
Physical state |
liquid |
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density |
1.596 g cm −3 (20 ° C) |
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Melting point |
−4 ° C |
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boiling point |
58.2 ° C |
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Vapor pressure |
160 h Pa (20 ° C) |
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solubility |
soluble in water |
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safety instructions | ||||||||||||||||
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Toxicological data | ||||||||||||||||
Global warming potential |
221 (based on 100 years) |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Hexafluoroisopropanol or hexafluoro-2-propanol , or HFIP for short , is an organic compound with the formula (CF 3 ) 2 CHOH. This fluorinated alcohol is used as a solvent . The colorless, volatile liquid is characterized by a strong, pungent odor. HFIP is miscible with water, methanol , 2-propanol and hexanes , but immiscible with acetonitrile . HFIP reacts as a weak acid in water because the electron-withdrawing CF 3 groups increase the acidity of the OH group .
Hexafluoroisopropanol as a solvent is characterized by a high polarity (E N T = 1.07) and as a strong hydrogen bond donor. However, it is only a weak hydrogen bridge acceptor and has a low nucleophilicity.
synthesis
Hexafluoroisopropanol, by hydrogenation of hexafluoroacetone be won.
Individual evidence
- ↑ a b c d e f g h data sheet 1,1,1,3,3,3-hexafluoro-2-propanol (PDF) from Carl Roth , accessed on March 26, 2014.
- ↑ Data sheet 1,1,1,3,3,3-hexafluoro-2-propanol (PDF) from Merck , accessed on March 26, 2014.
- ↑ G. Myhre, D. Shindell et al .: Climate Change 2013: The Physical Science Basis . Working Group I contribution to the IPCC Fifth Assessment Report. Ed .: Intergovernmental Panel on Climate Change . 2013, Chapter 8: Anthropogenic and Natural Radiative Forcing, pp. 24-39; Table 8.SM.16 ( PDF ).
- ↑ A. Apffel, JA Chakel, S. Fisher, K. Lichtenwalter, WS Hancock: Analisis of Oligonucleotides by HPLC-Electrospray Ionization Mass Spectroscopy. In: Anal. Chem. 69, 1997, pp. 1320-1325.
- ↑ Jean-Pierre Begue, Daniele Bonnet-DELPON, Benoit Crousse: Fluorinated Alcohols: A New Medium for Selective Reaction and Clean . In: SYNLETT . 2004.
- ↑ Patent US4314087 : Methods of synthesizing hexafluoroisopropanol from impure mixtures and synthesis of a fluoromethyl ether therefrom. Filed December 26, 1979 , published February 2, 1982 , Applicant: Baxter Travenol Laboratories, Inventor: Phillip C. Radlick.