To'laganova, who enjoyed playing on clay as well as hard courts, began playing tennis at the age of nine.
In 1999 she won the Wimbledon Championships in singles and the US Open in doubles. From 1996 she played 45 games for the Uzbek Fed Cup team (the last three after her resignation in 2010 in February 2012 all in doubles), of which she was able to win 25.
In her career she won three singles and four doubles titles on the WTA Tour and on ITF tournaments. She achieved her best world ranking positions in 2002 with places 16 in singles and 28 in doubles.