Khellinin

Structural formula
	Khellosid ( Glycoside of Khellol)
General
Surname	Khellinin
other names	Khellosid; Kellol glycoside;
Molecular formula	C 19 H 20 O 10
Brief description	yellowish crystal powder
External identifiers / databases
EC number	241-263-3
ECHA InfoCard	100,037,497
PubChem	28404
ChemSpider	390535
Wikidata	Q1740621
properties
Molar mass	444.38 g · mol -1
Physical state	firmly
Melting point	179 ° C
solubility	soluble in hot ethanol and acetic acid ; slightly soluble in water and hot methanol ;
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
Toxicological data	178 mg kg −1 ( LD 50 , mouse , im ) ; 1469 mg kg −1 ( LD 50 , rat , oral ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

The khellinin or khellosid is a cardiac glycoside of chromone derivatives of various plants such as the bishop's herb ( Ammi visnaga ) and the winterling ( Eranthis hyemalis ). The aglycon of the khellinin is the khellol . The white to yellowish, odorless khellinin is soluble in acetic acid and hot ethanol , but little in water. The related khellin also found in bishop's herb is highly toxic.

Structural formula of Khellol.
Structure of the related khellin.

In primates (such as macaques Cynomolgus and Macaca fascicularis ) khellinin was able to lower the plasma concentration of LDL and HDL lipoproteins .

literature

K. Samaan, AM Hossein: The existence in Ammi visnaga of a cardiac depressant principle visammin and a cardiac stimulant glycoside khellinin. In: J Egypt Med Assoc. 33 (12) 1950, pp. 953-960. PMID 14814677
A. Sibille et al.: Clinical trial of a new coronary vasodilator: khellinin. In: Brux Med. 34 (9) 1954, pp. 367-71. PMID 13140893
Egon Stahl , Werner Schild (1986): Isolation and characterization of natural substances . Gustav Fischer Verlag, ISBN 3-437-30511-5 , p. 114.

Individual evidence

↑ ^a ^b Max Daunderer: Clinical Toxicology. Poison information, poison detection, poisoning therapy . ecomed, 1988, ISBN 3-609-70000-9 .
↑ ^a ^b ^c F. v. Bruchhausen, M. Albinus, H. Hager: Hager's handbook of pharmaceutical practice. Volume 4: Substances AK. 5th edition. Springer, 1999, ISBN 3-540-62644-1 , p. 762.
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ ^a ^b Entry on khellinin in the ChemIDplus database of the United States National Library of Medicine (NLM) .
↑ ^a ^b Journal of Drug Research. Vol. 7 (2), p. 1, 1975.
↑ External identifiers or database links for Khellol : CAS number: 478-79-5, PubChem : 164613 , ChemSpider : 144309 , Wikidata : Q83070196 .
↑ External identifiers of or database links to Khellin : CAS number: 82-02-0, EC number: 201-392-8, ECHA InfoCard: 100.001.267 , PubChem : 3828 , ChemSpider : 3696 , Wikidata : Q2079998 .
↑ Data sheet Khellin (PDF) from Carl Roth , accessed on March 17, 2010.

[Daunderer-1] Max Daunderer: Clinical Toxicology. Poison information, poison detection, poisoning therapy . ecomed, 1988, ISBN 3-609-70000-9 .

[hager-2] F. v. Bruchhausen, M. Albinus, H. Hager: Hager's handbook of pharmaceutical practice. Volume 4: Substances AK. 5th edition. Springer, 1999, ISBN 3-540-62644-1 , p. 762.

[NV-3] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[chemID-4] Entry on khellinin in the ChemIDplus database of the United States National Library of Medicine (NLM) .

[jdr-5] Journal of Drug Research. Vol. 7 (2), p. 1, 1975.

[6] External identifiers or database links for Khellol : CAS number: 478-79-5, PubChem : 164613 , ChemSpider : 144309 , Wikidata : Q83070196 .

[7] External identifiers of or database links to Khellin : CAS number: 82-02-0, EC number: 201-392-8, ECHA InfoCard: 100.001.267 , PubChem : 3828 , ChemSpider : 3696 , Wikidata : Q2079998 .

[8] Data sheet Khellin (PDF) from Carl Roth , accessed on March 17, 2010.