Markus Kalesse

Markus Kalesse, 2017

Markus Kalesse (born March 19, 1961 in Osterode am Harz ) is a German chemist . He has been Professor at the Institute for Organic Chemistry at Leibniz Universität Hannover since 2003 and Head of the Department for Medicinal Chemistry at the Helmholtz Center for Infection Research (HZI) in Braunschweig since 2005 .

Life

Kalesse studied chemistry from 1982 to 1988 at the Leibniz University in Hanover and wrote his diploma thesis under the direction of Dieter Schinzer . He obtained his doctoral degree ( Dr. rer. Nat. ) In 1991 with the thesis “Structure of bicyclo [2.2.2] octanones through silica gel-induced cyclization of ketene acetals and double Michael addition ”, also under the direction of Dieter Schinzer . This was followed by two postdoctoral stays with Steven D. Burke (1991–1992) and Laura L. Kiessling (1992) at the University of Wisconsin in Madison (USA). Under Ekkehard Winterfeldt , he completed his habilitation in 1997 at the Leibniz University in Hanover in the field of organic chemistry . Between 1998 and 2000 guest professorships followed at the University of Wisconsin in Madison (USA) and at the Christian-Albrechts-Universität zu Kiel . He returned to Leibniz Universität Hannover in 2000 as senior academic adviser before taking up a professorship at the Free University of Berlin in 2002 . Since 2003 he has been Professor of Organic Chemistry at Leibniz Universität Hannover , and since 2005 Head of the Medicinal Chemistry Department at the Helmholtz Center for Infection Research (HZI) in Braunschweig .

Act

His research deals with the synthesis of complex natural products , with an emphasis on polyketides and polyketide-peptide hybrids, as well as the development of methods for stereoselective synthesis . Under his guidance, numerous initial syntheses of complex natural products have so far been successfully carried out, with ratjadon , tedanolide and chivosazole being examples. In addition to the total synthesis of natural products , the biological profile of these is also evaluated in cooperation. The focus of his methodical work is on the stereoselective synthesis of aldol products by Mukaiyama aldol reactions , as well as vinylogous Mukaiyama aldol reactions (VMAR). New ketene acetals were developed and the influence of chiral Lewis acids was investigated. In addition to his synthetic interests, Kalesse also deals with the structure elucidation of natural substances . In the course of this he was significantly involved in the development of a "Profile Hidden Markov" model for determining the absolute stereochemistry of secondary alcohols and α-methyl branches, which is based on the gene clusters of the corresponding polyketide synthases .

His academic students include Mathias Christmann ( Free University of Berlin ), Mike Boysen, Dirk Menche ( Rheinische Friedrich-Wilhelms-Universität Bonn ), Tanja Gaich ( University of Konstanz ), Evgeny Prusov ( Helmholtz Center for Infection Research , Braunschweig ) and Haihua Lu ( Nanjing Tech University ).

Web links

• Prof. Dr. rer. nat. Markus Kalesse at the Gottfried Wilhelm Leibniz University in Hanover
• Prof. Dr. rer. nat. Markus Kalesse at the Helmholtz Center for Infection Research

Individual evidence

1. ↑ Markus Kalesse, Angew. Chem. Int. Ed. 2013 , 52 , 12775, doi : 10.1002 / anie.201305415 .
2. ↑ Total Synthesis of (+) - Ratjadone, Angew. Chem. Int. Ed. 2000 , 39 , 4364-4366, doi : 10.1002 / 1521-3773 (20001201) 39:23 <4364 :: AID-ANIE4364> 3.0.CO; 2-G .
3. ↑ The Total Synthesis of (+) - Tedanolide, J. Am. Chem. Soc. 2006 , 128 , 14038-14039, doi : 10.1021 / ja0659572 .
4. ↑ Total Synthesis of Chivosazole F, J. Am. Chem. Soc. 2010 , 132 , 13610-13611, doi : 10.1021 / ja107290s .
5. ↑ a) A Kiyooka Aldol Approach for the Synthesis of the C (14) –C (23) Segment of the Diastereomeric Analog of Tedanolide C, Org. Lett. 2011 , 13 , 6038-6041, doi : 10.1021 / ol202515x ; b) Syn- Selective Vinylogous Kobayashi Aldol Reaction, Org. Lett. 2012 , 14 , 1608-1611, doi : 10.1021 / ol300353w .
6. ↑ Enantioselective synthesis of polyketide segments through vinylogous Mukaiyama aldol reactions, Tet. Lett. 2009 , 50 , 3485-3488, doi : 10.1016 / j.tetlet.2009.03.013 .
7. ↑ a) Configurational Assignment of Secondary Hydroxyl Groups and Methyl Branches in Polyketide Natural Products through Bioinformatic Analysis of the Ketoreductase Domain, ChemBioChem 2013 , 14 , 851–861, doi : 10.1002 / cbic.201300063 ; b) The Structure Elucidation and Total Synthesis of β-Lipomycin, Angew. Chem. Int. Ed. 2014 , 53 , 7335–7338, doi : 10.1002 / anie.201402259 .