Mezlocillin

Structural formula
General
Surname	Mezlocillin
other names	(2 S , 5 R , 6 R ) -3,3-dimethyl-6 - {[(2 R ) -2 - ({[3- (methylsulfonyl) -2-oxo-1-imidazolidinyl] carbonyl} amino) - 2-phenylacetyl] amino} -7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid ( IUPAC ) ; [( R ) -α- (3-methanesulfonyl-2-oxoimidazolidine-1-carboxamido) benzyl] penicillin;
Molecular formula	C 21 H 24 N 5 O 8 S 2
External identifiers / databases
EC number	257-233-8
ECHA InfoCard	100.052.013
PubChem	656511
ChemSpider	570894
DrugBank	DB00948
Wikidata	Q3307752
Drug information
ATC code	J01 CA10
Drug class	β-lactam antibiotic
Mechanism of action	Inhibition of septum formation and cell wall synthesis
properties
Molar mass	539.57 g mol −1
Physical state	firmly
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling ; no classification available
Toxicological data	> 20 g kg −1 ( LD 50 , rat , oral ) ; 2636 mg kg −1 ( LD 50 , rat , iv ) ; > 16 g kg −1 ( LD 50 , mouse , oral ) ; 6329 mg kg −1 ( LD 50 , mouse , iv ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Mezlocillin is an organic chemical compound from the group of β-lactam antibiotics , more precisely the ureidopenicillins (acylaminopenicillins). It was patented by Bayer AG in 1974 . The broad spectrum antibiotic is used in the form of the sodium salt - monohydrate . Its wide spectrum of activity enables it to be effective against both Gram-negative and some Gram-positive bacteria. The drug is suitable, for example, for the treatment of an infection of the biliary tract.

use

Mezlocillin is mainly used for different infections at different locations and with different degrees of intensity. These can be, for example, infections of the deeper respiratory tract, the gastrointestinal tract, the biliary tract or the kidney and its urinary tract. In addition, the agent can be used for infections of the genital organs or for obstetrics. Mezlocillin is not absorbed through the gastrointestinal tract and can therefore only be given as an injection or infusion.

Side effects

Mezlocillin intake can affect the body in many different forms. As with all penicillins , there is the possibility, among other things, that the substance affects the nervous system, the psyche, the immune system, the respiratory tract and the taste. Mezlocillin can also cause platelet dysfunction , joint pain or temporary changes in laboratory values such as bilirubin and creatinine .

Interactions

Anticoagulants and antiplatelet drugs may interact with mezlocillin. If muscle relaxants are taken in conjunction with mezlocillin, this can lead to an increase in the neuromuscular blocks.

Individual evidence

^ A. Kleemann , J. Engel, B. Kutscher, D. Reichert: Pharmaceutical Substances [Online] . Thieme, Stuttgart, https://pharmaceutical-substances.thieme.com/ [test date March 26, 2020].
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ ^a ^b ^c ^d ^e entry on mezlocillin. In: Römpp Online . Georg Thieme Verlag, accessed on March 26, 2020.
↑ H. Lode, U. Niestrath, P. Koeppe, H. Langmaack: Azlocillin and Mezlocillin: Two new semisynthetic acylureidopenicillins . In: Infection . tape 5 , no. 3 , 1977, pp. 163-169 , doi : 10.1007 / bf01639753 , PMID 334673 .
↑ Kwung P. Fu, Harold C. New: Azlocillin and Mezlocillin: New Ureido Penicillins . In: Antimicrobial Agents and Chemotherapy . tape 13 , no. 6 June 1978, p. 930-938 , doi : 10.1128 / aac.13.6.930 .
↑ ^a ^b ^c Peter Finck, Stefanie Heinze, Ulrike Raths, Uwe Riecken, Axel Ssymank: Red List of Endangered Biotope Types in Germany . Federal Agency for Nature Conservation, Bonn-Bad Godesberg, 2017, ISBN 978-3-7843-4056-2 , p. 337.
↑ L. Weingärtner, U. Sitka, R. Patsch, H. Thiemann: Experiences with acylureido penicillins (azlocillin mezlocillin) * in paediatrics . In: Clinical Pediatrics . tape 196 , no. 1 , 1984, p. 28-35 , doi : 10.1055 / s-2007-1025569 .

[Pharmaceutical_Substances-1] A. Kleemann , J. Engel, B. Kutscher, D. Reichert: Pharmaceutical Substances [Online] . Thieme, Stuttgart, https://pharmaceutical-substances.thieme.com/ [test date March 26, 2020].

[NV-2] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[Römpp-3] ↑ ^a ^b ^c ^d ^e entry on mezlocillin. In: Römpp Online . Georg Thieme Verlag, accessed on March 26, 2020.

[4] H. Lode, U. Niestrath, P. Koeppe, H. Langmaack: Azlocillin and Mezlocillin: Two new semisynthetic acylureidopenicillins . In: Infection . tape 5 , no. 3 , 1977, pp. 163-169 , doi : 10.1007 / bf01639753 , PMID 334673 .

[5] Kwung P. Fu, Harold C. New: Azlocillin and Mezlocillin: New Ureido Penicillins . In: Antimicrobial Agents and Chemotherapy . tape 13 , no. 6 June 1978, p. 930-938 , doi : 10.1128 / aac.13.6.930 .

[Fink-6] Peter Finck, Stefanie Heinze, Ulrike Raths, Uwe Riecken, Axel Ssymank: Red List of Endangered Biotope Types in Germany . Federal Agency for Nature Conservation, Bonn-Bad Godesberg, 2017, ISBN 978-3-7843-4056-2 , p. 337.

[7] L. Weingärtner, U. Sitka, R. Patsch, H. Thiemann: Experiences with acylureido penicillins (azlocillin mezlocillin) * in paediatrics . In: Clinical Pediatrics . tape 196 , no. 1 , 1984, p. 28-35 , doi : 10.1055 / s-2007-1025569 .