Michael N. Hall

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Michael N. Hall, 2014

Michael Nip Hall (born June 12, 1953 in Puerto Rico ) is an American - Swiss molecular biologist and professor at the Biozentrum of the University of Basel .

Life

Hall spent his childhood and youth in South America ( Venezuela , Peru ). He earned a bachelor's degree in zoology from the University of North Carolina at Chapel Hill in 1976 and a PhD from Thomas J. Silhavy at Harvard University in 1981 . His doctoral thesis was entitled Genetic studies on the regulation of the major outer membrane porin proteins of Escherichia coli K-12 . Hall worked as a postdoctoral fellow at the Pasteur Institute in Paris and with Ira Herskowitz at the University of California, San Francisco . In 1987 Hall went to the Biozentrum of the University of Basel as an assistant professor , and in 1992 he was given a full professorship. From 1995 to 1998 and from 2002 to 2009 he headed the department for biochemistry there , and from 2002 to 2009 he was Vice Director of the Biozentrum.

Act

In 1991 Hall discovered the protein kinase TOR . Hall is considered to be a leader in research into the TOR signaling pathway (in mammals, mTOR ), which plays a crucial role in numerous processes of cell growth . The TOR signaling pathway is also important in the aging process and obesity or various diseases such as cancer , diabetes mellitus or cardiovascular diseases . Substances that intervene here are considered to be potential therapeutics for numerous diseases. Since 2016 Thomson Reuters has counted him among the favorites for a Nobel Prize ( Thomson Reuters Citation Laureates ) due to the number of his citations .

Awards (selection)

Publications (selection)

  • J. Heitman, NR Movva, MN Hall: Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. In: Science. Volume 253, 1991, pp. 905-909.
  • T. Schmelzle, MN Hall: TOR, a central controller of cell growth. In: Cell. Volume 103, 2000, pp. 253-262.
  • R. Loewith, E. Jacinto, S. Wullschleger, A. Lorberg, JL Crespo, D. Bonenfant, W. Oppliger, P. Jenoe, MN Hall: Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. In: Mol. Cell. Volume 10, 2002, pp. 457-468.
  • S. Wullschleger, R. Loewith, MN Hall: TOR signaling in growth and metabolism. In: Cell. Volume 124, 2006, pp. 471-484.
  • AM Robitaille, S. Christen, M. Shimobayashi, LL Fava, M. Cornu, S. Moes, C. Prescianotto-Baschong, U. Sauer, P. Jenoe, MN Hall: Quantitative phosphoproteomics reveal mTORC1 phosphorylates CAD and activates de novo pyrimidine synthesis. In: Science. Volume 339, 2013, pp. 1320-1323.

Web links

Individual evidence

  1. ↑ Curriculum Vitae ( Memento from February 20, 2016 in the Internet Archive ) at the Marcel Benoist Foundation (marcel-benoist.ch).
  2. ↑ Web of Science Predicts 2016 Nobel Prize Winners. (No longer available online.) In: ipscience.thomsonreuters.com. Archived from the original on September 21, 2016 ; accessed on September 21, 2016 (English).
  3. ↑ Cloëtta Prize at the Prof. Dr. Foundation Max Cloëtta (cloetta-stiftung.ch). Retrieved September 26, 2012.
  4. ^ Fondation Louis-Jeantet - Lauréats. In: jeantet.ch. Retrieved February 11, 2016 (French).
  5. ↑ Michael N. Hall, Professor at the Biozentrum of the University of Basel, has been awarded this year's Marcel Benoist Prize at the Marcel Benoist Foundation (marcel-benoist.ch). Retrieved September 26, 2012.
  6. ↑ Sir Hans Krebs Lecture ( Memento from January 16, 2014 in the Internet Archive ) FEBS-EMBO 2014. Accessed June 24, 2014.
  7. ^ Breakthrough Prize. In: breakthroughprize.org. Retrieved February 20, 2016 .
  8. ↑ ERC Synergy Grant: Basel researchers receive CHF 13.7 million for cancer research - University of Basel. In: unibas.ch. Retrieved February 20, 2016 .
  9. ↑ Michael N. Hall at the National Academy of Sciences (nasonline.org); accessed on May 1, 2019.
  10. ↑ Michael N. Hall: Recipient of the Canada Gairdner International Award, 2015 at the Gairdner Foundation (gairdner.org). Retrieved March 31, 2015.
  11. ↑ Debrecen Award for Molecular Medicine 2016. In: unideb.hu. Retrieved May 1, 2019 .
  12. ↑ Michael Hall receives an honorary doctorate from the University of Geneva - University of Basel. In: unibas.ch. October 14, 2016, accessed May 15, 2017 .
  13. ↑ 2017 Prize: Michael N. Hall, Ph.D. In: nfcr.org. Retrieved May 1, 2019 .
  14. ^ Howard Taylor Ricketts Award. In: medicine.uchicago.edu. Accessed April 27, 2019 .
  15. ↑ List of publications at Biozentrum of the University of Basel (biozentrum.unibas.ch). Retrieved October 16, 2013.
personal data
SURNAME Hall, Michael N.
ALTERNATIVE NAMES Hall, Michael Nip
BRIEF DESCRIPTION American-Swiss molecular biologist
DATE OF BIRTH June 12, 1953
PLACE OF BIRTH Puerto Rico