Mina J. Bissell

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Mina J. Bissell (* 1940 in Tehran ) is an Iranian - American cell and molecular biologist at the Lawrence Berkeley National Laboratory . She is best known for her work on the role of the extracellular matrix and microenvironment in cell differentiation , programmed cell death, and cancer (especially breast cancer ).

Live and act

Bissell grew up in Tehran and received a scholarship at the age of 18, initially to Bryn Mawr College . She earned a bachelor's degree in chemistry from Radcliffe College in 1963 , a master's degree in bacteriology and biochemistry from Harvard University Medical School in 1964, and a Ph.D. from Harvard University in 1969. in microbiology and molecular genetics . She worked as a postdoctoral fellow at the University of California, Berkeley before joining the Lawrence Berkeley National Laboratory (LBNL) in 1972 . Here she became a senior scientist in 1977 , head of cell biology and molecular biology in 1988 and director of the entire life sciences in 1992 . She resigned from this position in 2002 and has continued to work as a researcher for the LBNL ever since. She is also teaching at the University of California, Berkeley and the University of California, San Francisco .

Bissell's early work in the 1970s looked at the uptake of glucose and glycolysis in normal tissue and in cancer cells . She was later able to show that the oncogenic effect of an oncogene is context-dependent. In the 1980s and 1990s, she studied the plasticity of cancer cells and normal cells depending on the microenvironment. Breast cancer cells behaved like healthy cells in a certain extracellular matrix . Conversely, healthy cells began to develop tumors when their normal extracellular matrix was destroyed by metalloproteases . More recent work by Bissell deals with the "dynamic reciprocity" between the signals from the microenvironment and the signals from the nucleus and chromatin .

Bissell has published more than 400 scientific publications (as of 2017) . She was one of the editors of various journals, including Science . In 1997 she was President of the American Society for Cell Biology . Mina Bissell is a second married woman and has two children.

Awards (selection)

The Institute for Pathology and Immunology at the University of Porto has been presenting the Mina J. Bissell Award every two years since 2008 for the outstanding lifetime achievement of a cancer researcher. Bissell was the first winner herself.

Web links

literature

  • M. Bissell: Balancing work and life: a conversation with Mina Bissell. Interviewed by Majlinda Lako and Susan Hence. In: Stem cells. Volume 27, Number 8, August 2009, pp. 1709-1711, doi: 10.1002 / stem.175 , PMID 19593796 .
  • Gina Kolata: Old Ideas Spur New Approaches in Cancer Fight. In: nytimes.com. December 28, 2009, accessed March 18, 2017 .
  • MJ Bissell: Thinking in three dimensions: discovering reciprocal signaling between the extracellular matrix and nucleus and the wisdom of microenvironment and tissue architecture. In: Molecular biology of the cell. Volume 27, number 21, November 2016, pp. 3205-3209, doi: 10.1091 / mbc.E16-06-0440 , PMID 27799496 , PMC 5170853 (free full text).

Individual evidence

  1. ^ ASCB Presidents at the American Society for Cell Biology (ascb.org); accessed on March 18, 2017.
  2. ^ John Simon Guggenheim Foundation - Mina J. Bissell. In: gf.org. Retrieved March 18, 2017 (English).
  3. ↑ Mina J. Bissell, 1996 - US DOE Office of Science (SC). In: science.energy.gov. Retrieved March 15, 2017 (English).
  4. ↑ Book of Members 1780 – present, Chapter B. (PDF; 1.2 MB) In: American Academy of Arts and Sciences (amacad.org). Retrieved September 23, 2019 .
  5. ↑ histoire: Mina J. Bissel, Prix Etranger 2007 / Histoire de l'Inserm. In: histoire.inserm.fr. Retrieved March 15, 2017 (French).
  6. ^ American Philosophical Society - Member History. In: amphilsoc.org. Retrieved March 15, 2017 .
  7. ↑ Mina Bissell. In: nasonline.org. Retrieved March 15, 2017 .
  8. ↑ EB Wilson Medalists at the American Society for Cell Biology (ascb.org); accessed on March 15, 2017.
  9. ↑ a b E.B. Wilson Medal-Mina Bissell at the American Society for Cell Biology (ascb.org); accessed on March 15, 2017.
  10. ^ AACR Award for Lifetime Achievement in Cancer Research. In: aacr.org. Retrieved March 15, 2017 (English).
  11. ^ Mina J. Bissell Award (PDF, 603 kB) at the Lawrence Berkeley National Laboratory (lbl.org); accessed on March 15, 2017.
personal data
SURNAME Bissell, Mina J.
ALTERNATIVE NAMES Bissell, Mina
BRIEF DESCRIPTION Iranian-American cell and molecular biologist
DATE OF BIRTH 1940
PLACE OF BIRTH Tehran