Nicotyrine

Structural formula
General
Surname	Nicotyrine
other names	3- (1-methyl-pyrrol-2-yl) pyridine; 1-methyl-2- (3-pyridyl) pyrrole; 3- (1-methyl-1 H -pyrrole-2-yl) -pyridine; α-nicotyrine;
Molecular formula	C 10 H 10 N 2
External identifiers / databases
EC number	207-651-1
ECHA InfoCard	100.006.956
PubChem	10249
Wikidata	Q1987338
properties
Molar mass	158.20 g · mol -1
Physical state	liquid
density	1.24 g cm −3 (20 ° C)
boiling point	280–281 ° C (at 992 h Pa )
Refractive index	1.6057
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
Toxicological data	575 mg kg −1 ( LD 50 , mouse , oral ) ; 750 mg kg −1 ( LD 50 , rat , iv ) ; 191 mg kg −1 ( LD 50 , mouse , ip ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

Nicotyrin is a chemical compound from the class of heterocycles . It consists of a pyridine ring and a methyl- substituted pyrrole ring , which are linked by their rings.

Occurrence

Field with tobacco plants

Nicotyrin is one of the tobacco alkaloids and occurs naturally in tobacco plants . In a comparison of 52 smoking tobacco, 0.08–0.4 mg nicotyrine could be detected per gram of tobacco.

presentation

Nicotyrin can chemically by dehydration of nicotine on palladium are recovered.

Individual evidence

↑ ^a ^b ^c R. L. Frank, RW Holley, DM Wikholm: 3,2′-nicotyrine. Insecticidal Properties of Certain Azo Derivatives , in: J. Am. Chem. Soc. , 1942 , 64 , pp. 2835-2838.
↑ F. Blau: Zur Constitution des Nicotins , in: Chem. Ber. , 1894 , 27 , pp. 2535-2539.
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ ^a ^b ^c Entry on α-nicotyrine in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on July 31, 2018 or earlier.
↑ Careen Merckel, Fritz Pragst : Analysis of cigarettes on additives , Institute of Forensic Medicine, Charité Berlin, 2005..

[frank-1] R. L. Frank, RW Holley, DM Wikholm: 3,2′-nicotyrine. Insecticidal Properties of Certain Azo Derivatives , in: J. Am. Chem. Soc. , 1942 , 64 , pp. 2835-2838.

[2] F. Blau: Zur Constitution des Nicotins , in: Chem. Ber. , 1894 , 27 , pp. 2535-2539.

[NV-3] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[ChemID-4] Entry on α-nicotyrine in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on July 31, 2018 or earlier.

[5] Careen Merckel, Fritz Pragst : Analysis of cigarettes on additives , Institute of Forensic Medicine, Charité Berlin, 2005..