Nimodipine
Structural formula | |||||||||||||||||||
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Structural formula without stereochemistry - 1: 1 mixture ( racemate ) | |||||||||||||||||||
General | |||||||||||||||||||
Non-proprietary name | Nimodipine | ||||||||||||||||||
other names |
2,6-Dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylic acid-3-isopropyl ester-5- (2-methoxyethyl) ester ( IUPAC ) |
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Molecular formula | C 21 H 26 N 2 O 7 | ||||||||||||||||||
Brief description |
colorless solid |
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properties | |||||||||||||||||||
Molar mass | 418.44 g · mol -1 | ||||||||||||||||||
Physical state |
firmly |
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solubility |
almost insoluble in water |
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Toxicological data | |||||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Nimodipine ( trade name : Nimotop ® , manufacturer: Bayer ) is a medicinal substance ( calcium channel blocker ) from the group of 1,4-dihydropyridines .
By blocking calcium channels, it has a relaxing effect on vascular muscles, supposedly especially in the brain. It is used after subarachnoid hemorrhages to prevent vasospasms (vascular spasms) and thus to ensure cerebral blood flow. (Vascular spasms of this kind can be triggered by serotonin and hemoglobin breakdown products.)
Nimodipine is also approved for age-related brain disorders ( nootropic ).
Stereochemistry
Nimodipine contains a stereocenter and consists of two enantiomers, more precisely two atropisomers . This is a racemate , i.e. a 1: 1 mixture of ( R ) - and ( S ) -form:
Enantiomers of nimodipine | |
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CAS number: 77940-92-2 |
CAS number: 77940-93-3 |
Individual evidence
- ↑ a b c d e data sheet Nimodipine from Sigma-Aldrich , accessed on April 16, 2011 ( PDF ).
- ↑ Red List online, as of October 2009.
- ↑ AM comp. d. Switzerland, as of October 2009.
- ↑ AGES-PharmMed, as of October 2009.
- ↑ Rote Liste Service GmbH (Ed.): Rote Liste 2017 - drug directory for Germany (including EU approvals and certain medical devices) . Rote Liste Service GmbH, Frankfurt / Main, 2017, edition 57, ISBN 978-3-946057-10-9 , p. 204.