Oleandrin

Structural formula
General
Surname	Oleandrin
Molecular formula	C 32 H 48 O 9
External identifiers / databases
EC number	207-361-5
ECHA InfoCard	100.006.693
PubChem	11541511
ChemSpider	9716290
DrugBank	DB12843
Wikidata	Q411532
properties
Molar mass	576.72 g · mol -1
Physical state	firmly
Melting point	250 ° C (from dilute methanol )
solubility	practically insoluble in water, soluble in ethanol and chloroform
safety instructions
H and P phrases	H: 300-330-373
	P: 260-264-284-301 + 310-310
Toxicological data	0.248 mg kg −1 ( LD 50 , cat , iv )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Oleandrin is a toxic cardiac glycoside found in oleander ( Nerium oleander ).

Oleander ( Nerium oleander )

Along with neandrin , it is mainly responsible for the toxicity of the oleander's juice. Ingestion of oleander can cause gastrointestinal and heart problems. The gastrointestinal complaints can manifest themselves in the form of nausea and vomiting, excess saliva , abdominal pain and diarrhea . The heart complaints can include an irregular pulse and rapid palpitations leading to a below-average pulse rate. The extremities become pale and cold from the poor circulation. The symptoms of poisoning can also affect the central nervous system ( CNS ), include drowsiness, tremors, or muscle tremors leading to breakdown into a coma, and ultimately death. The juice of the oleander can cause skin irritation, serious eye infections and allergic reactions in the form of dermatitis .

Individual evidence

^ ^A ^b The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; ISBN 978-0-911910-00-1 .
↑ ^a ^b Oleandrin data sheet from Sigma-Aldrich , accessed on April 16, 2011 ( PDF ).

↑ Entry on oleandrin in the ChemIDplus database of the United States National Library of Medicine (NLM) .

↑ Poisons Information Monograph (PIM) for Nerium oleander L. , accessed April 16, 2017.

↑ ^a ^b ^c Rebecca J. Goetz, Thomas N. Jordan, John W. McCain, Nancy Y. Su: Oleander. In: Indiana Plants Poisonous to Livestock and Pets. Cooperative Extension Service, Purdue University , 1998, archived from the original on June 23, 2010 ; Retrieved October 23, 2005 .

[MERCK_Index-1] A ^b The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; ISBN 978-0-911910-00-1 .

[Sigma-2] Oleandrin data sheet from Sigma-Aldrich , accessed on April 16, 2011 ( PDF ).

[ChemIDplus-3] Entry on oleandrin in the ChemIDplus database of the United States National Library of Medicine (NLM) .

[inchem-4] Poisons Information Monograph (PIM) for Nerium oleander L. , accessed April 16, 2017.

[Goetz-5] Rebecca J. Goetz, Thomas N. Jordan, John W. McCain, Nancy Y. Su: Oleander. In: Indiana Plants Poisonous to Livestock and Pets. Cooperative Extension Service, Purdue University , 1998, archived from the original on June 23, 2010 ; Retrieved October 23, 2005 .