Peter C. Nowell

from Wikipedia, the free encyclopedia

Peter Carey Nowell (born February 8, 1928 in Philadelphia - † December 26, 2016 ) was an American pathologist and cancer researcher .

Live and act

Nowell earned a bachelor's degree in biochemistry from Wesleyan University in Middletown , Connecticut in 1948 and an MD from the University of Pennsylvania in Philadelphia in 1952 with a medical degree. After several posts as a postdoctoral fellow and military service at the US Naval Radiological Defense Lab , Nowell became a faculty member at the University of Pennsylvania in 1956. In 1964 he got there a full professor of pathology and was from 1967 to 1973 professor of pathology. Nowell was the founding director of the Cancer Center there (about: Cancer Research Center). In 2003 Nowell retired.

In the early 1960s, it was state of the art that infection with viruses can lead to cancer in a large number of cells. Nowell discovered the Philadelphia chromosome in 1960 , with which a characteristic and regularly encountered chromosome aberration as the cause of cancer (here for chronic myeloid leukemia , CML) could be identified for the first time. As a result, the research field and the diagnostic field of cancer cytogenetics developed . Nowell developed a now widely recognized model of oncogenesis through multiple genetic changes in a single cell that ultimately transforms malignantly .

Nowell's further successes were the discovery that fatally irradiated organisms can survive with a bone marrow transplant and that, conversely, previous irradiation increases the probability of a bone marrow transplant being successful. Nowell, the method could be established also with lectins , the division of white blood cells to induce.

Awards (selection)

literature

Web links

Individual evidence

  1. ^ The 1988 Fred W. Stewart Award. In: The American Journal of Surgical Pathology . Volume 13, Number 8, August 1989, pp. 713-714, ISSN  0147-5185 . PMID 2665537 . on-line
  2. Peter Nowell Obituary. In: legacy.com. December 26, 2016, accessed January 5, 2017 .
  3. ^ Recipients of the Passano Laureate and Physician Scientist Awards. In: passanofoundation.org. Accessed May 5, 2019 .
  4. ^ Charles S. Mott Prize (1979–1989) ( Memento of March 14, 2007 in the Internet Archive )
  5. Dr. Peter Carey Nowell at the American Philosophical Society (amphilsoc.org); Retrieved June 29, 2012
  6. ^ Albert Lasker Clinical Medical Research Award 1998 Winners at the Lasker Foundation (laskerfoundation.org); accessed on February 16, 2016
  7. Book of Members 1780 – present, Chapter N. (PDF; 283 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved May 7, 2019 .
  8. Peter C. Nowell, MD at the Franklin Institute (fi.edu); accessed on February 16, 2016
  9. ^ Cancer Treatment Pioneers to Share America's Most Distinguished Prize. In: amc.edu. April 16, 2013, accessed February 16, 2016 .