Peter C. Nowell
Peter Carey Nowell (born February 8, 1928 in Philadelphia - † December 26, 2016 ) was an American pathologist and cancer researcher .
Live and act
Nowell earned a bachelor's degree in biochemistry from Wesleyan University in Middletown , Connecticut in 1948 and an MD from the University of Pennsylvania in Philadelphia in 1952 with a medical degree. After several posts as a postdoctoral fellow and military service at the US Naval Radiological Defense Lab , Nowell became a faculty member at the University of Pennsylvania in 1956. In 1964 he got there a full professor of pathology and was from 1967 to 1973 professor of pathology. Nowell was the founding director of the Cancer Center there (about: Cancer Research Center). In 2003 Nowell retired.
In the early 1960s, it was state of the art that infection with viruses can lead to cancer in a large number of cells. Nowell discovered the Philadelphia chromosome in 1960 , with which a characteristic and regularly encountered chromosome aberration as the cause of cancer (here for chronic myeloid leukemia , CML) could be identified for the first time. As a result, the research field and the diagnostic field of cancer cytogenetics developed . Nowell developed a now widely recognized model of oncogenesis through multiple genetic changes in a single cell that ultimately transforms malignantly .
Nowell's further successes were the discovery that fatally irradiated organisms can survive with a bone marrow transplant and that, conversely, previous irradiation increases the probability of a bone marrow transplant being successful. Nowell, the method could be established also with lectins , the division of white blood cells to induce.
Awards (selection)
- 1976 member of the National Academy of Sciences
- 1984 Passano Award
- 1987 Robert de Villiers Award from the Leukemia Society of America
- 1989 Charles S. Mott Prize (with Janet Rowley )
- 1993 member of the American Philosophical Society
- 1998 Albert Lasker Clinical Medical Research Award (with Alfred G. Knudson and Janet Rowley )
- 2009 member of the American Academy of Arts and Sciences
- 2010 Benjamin Franklin Medal
- 2013 Albany Medical Center Prize
literature
- Mark I. Greene and Jonni S. Moore: Peter C. Nowell (1928-2016). In: Science . Volume 355, No. 6328, 2017, p. 913, doi: 10.1126 / science.aam9738
Web links
- From Chromosomes to Oncogenes: A Personal Perspective at the University of Pennsylvania (upenn.edu); accessed on February 16, 2016
Individual evidence
- ^ The 1988 Fred W. Stewart Award. In: The American Journal of Surgical Pathology . Volume 13, Number 8, August 1989, pp. 713-714, ISSN 0147-5185 . PMID 2665537 . on-line
- ↑ Peter Nowell Obituary. In: legacy.com. December 26, 2016, accessed January 5, 2017 .
- ^ Recipients of the Passano Laureate and Physician Scientist Awards. In: passanofoundation.org. Accessed May 5, 2019 .
- ^ Charles S. Mott Prize (1979–1989) ( Memento of March 14, 2007 in the Internet Archive )
- ↑ Dr. Peter Carey Nowell at the American Philosophical Society (amphilsoc.org); Retrieved June 29, 2012
- ^ Albert Lasker Clinical Medical Research Award 1998 Winners at the Lasker Foundation (laskerfoundation.org); accessed on February 16, 2016
- ↑ Book of Members 1780 – present, Chapter N. (PDF; 283 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved May 7, 2019 .
- ↑ Peter C. Nowell, MD at the Franklin Institute (fi.edu); accessed on February 16, 2016
- ^ Cancer Treatment Pioneers to Share America's Most Distinguished Prize. In: amc.edu. April 16, 2013, accessed February 16, 2016 .
personal data | |
---|---|
SURNAME | Nowell, Peter C. |
ALTERNATIVE NAMES | Nowell, Peter; Nowell, Peter Carey |
BRIEF DESCRIPTION | American pathologist and cancer researcher |
DATE OF BIRTH | February 8, 1928 |
PLACE OF BIRTH | Philadelphia |
DATE OF DEATH | December 26, 2016 |