Peter Propping

from Wikipedia, the free encyclopedia

Peter Propping (born December 21, 1942 in Berlin ; † April 26, 2016 in Bonn ) was a German human geneticist .

Peter Propping's scientific work areas included medical genetics , in particular the inheritance of genetically complex neuropsychiatric disorders such as alcoholism, manic-depressive illness , schizophrenia , epilepsy and cancer dispositions . He also studied the history of human genetics and eugenics. From 1984 to 2008 he was director of the Institute for Human Genetics at the University of Bonn .

Life

Peter Propping studied medicine at the Free University of Berlin from 1962 to 1968 , where he received his doctorate in 1970 after completing a thesis in pharmacology. Until his license to practice medicine, he worked in Berlin as a medical assistant in pharmacology, surgery and internal medicine. He then worked as a research assistant at the Institute for Anthropology at Heidelberg University . His habilitation in human genetics took place there in 1976 at the Faculty of Theoretical Medicine. In 1981 he received the additional designation "Medical Genetics" from the North Baden Medical Association. From 1980 to 1983 Propping was a Heisenberg fellow of the German Research Foundation for Genetics in Psychiatry . During this time he worked at the Central Institute for Mental Health in Mannheim and at the Institute for Human Genetics at the University of Heidelberg.

From 1984 to 2008 Propping was Professor of Human Genetics and Director of the Institute for Human Genetics at the University of Bonn. At the Medical Faculty he was Dean from 1990 to 1992, and from 1994 to 1996 Vice Rector for Research at the University of Bonn. In 1995 he was given the recently introduced designation “Specialist in Human Genetics” by the North Rhine Medical Association. From 1991 to 1997 he was coordinator of the priority program of the German Research Foundation “Genetic Factors in Psychiatric Diseases” and from 1996 to 2004 spokesman for the Graduate School “Pathogenesis of Diseases of the Nervous System”. From 1999 to 2012 Propping was the spokesman for the joint project of the German Cancer Aid “Familial Colon Cancer” and coordinator of the German HNPCC consortium. From 2006 to 2008 he was chairman of the German Society for Human Genetics . After his retirement in 2008, he was appointed Senior Professor at the University of Bonn by the Rector.

Scientific contributions

Propping was able to show that the metabolism in the intra-animal culture of bacteria for mutation generation by chemical substances is taken into account. He then compiled findings that suggest a genetic influence on the effect of psychotropic drugs and was able to show this in the effect of alcohol on the electroencephalogram (EEG) in a large twin study and on carriers of EEG variants as well as with regard to alcohol metabolism. Propping initiated a long-term study in Bonn to analyze the contribution of genetic factors to manic-depressive illness . Contrary to expectations, no decisive insights could be achieved with coupling studies. However, this was successful in rare forms of epilepsy. In large international genome-wide association studies with the participation of Propping it turned out that there is an overlap of the genetic disposition to different psychiatric disorders. In familial adenomatous polyposis , his working group was able to refine the genotype-phenotype relationship and, in the most common form of hereditary colon cancer syndrome, in very large family collectives, was able to demonstrate numerous relationships that are important for inheritance, diagnosis, prognosis and cancer prevention .

Honors and prizes

For his services to cancer research, Propping u. a. the following awards:

Memberships

Peter Propping was an expert on human genetics at the Institute for Medical and Pharmaceutical Examination Questions from 1993 to 2013. In 1997 he became a member of the Medical Advisory Board of the German Cancer Aid , since 2003 as its chairman, from 2004 to 2008 as chairman of the specialist committee for care. He was also a member of the board of this non-profit organization from 2010 to 2013. From 1999 to 2007 he was a member of the board of directors of the German Reference Center for Ethics in the Biosciences at the University of Bonn and from 2001 to 2007 a member of the project committee of the National Genome Research Network (NGFN) of the Federal Ministry of Education and Research. From 2001 to 2007 he was a member of the National Ethics Council; his appointment was made by resolution of the Federal Cabinet. In 2001 Propping was accepted into the German Academy of Sciences Leopoldina, and in 2008 he became a member of the Senate. Since 2010 he has been a member of the Presidium of the German Academy of Sciences Leopoldina - National Academy of Sciences. Since 2004 Propping has been a member of the Scientific Advisory Board of the German Medical Association. From 2008 to 2012 he was a member of the University Council of Bonn University.

Trivia

In 2008 Propping spoke out in the Frankfurter Allgemeine Zeitung for better pay for young professors. On the one hand, the salary of a W2 professor could be lower than that of a scientific assistant or magistrate . On the other hand, politicians want to facilitate the immigration of “highly qualified” people from abroad, with a minimum salary of 63,600 euros per year serving as a yardstick for high qualifications. For Propping, therefore, the conclusion is obvious that firstly a W2 professor in politics is apparently not considered a “highly qualified” person and secondly, the immigration of talented young people from abroad to a German university is not desired.

Selected publications (books)

  • F. Vogel, P. Propping: Is our fate born? Berlin 1981
  • P. Propping: Psychiatric Genetics. Findings and concepts. Berlin / Heidelberg / New York 1989
  • P. Propping, H. Schott (Ed.): Science on the wrong path. Biologism-Racial Hygiene-Eugenics. Bonn / Berlin 1992
  • T. J. Bouchard, P. Propping (Eds.): Twins as a Tool of Behavioral Genetics. Chichester./. New York ./. Brisbane ./. Toronto ./. Singapore ./. 1993
  • L. Honnefelder, P. Propping (Ed.): What do we know when we know the human genome? Cologne 2001
  • L. Honnefelder, D. Mieth, P. Propping (Ed.): The genetic knowledge and the future of humans. Berlin 2003

Web links

Individual evidence

  1. ^ Obituary notice Peter Propping , FAZ , April 30, 2016
  2. ^ Institute for Human Genetics
  3. ↑ P. Propping, W. Buselmaier: The influence of metabolism on mutagenic activity in the host-mediated assay. In: Archiv für Toxikologie, 28, 1971, pp. 129-134
  4. ↑ P. Propping, M. Kopun: Pharmacogenetic aspects of psychoactive drugs: facts and fancy. In: Humangenetik, 20, 1973, pp. 291-320
  5. ^ P. Propping: Genetic control of ethanol action on the central nervous system. An EEG study in twins. In: Human Genetics, 35, 1977, pp. 309-334
  6. ↑ M. Kopun, P. Propping: The kinetics of ethanol absorption and elimination in twins and supplementary repetitive experiments in singleton subjects. In: European Journal of Clinical Pharmacology, 11, 1977, pp. 337-344
  7. ^ P. Propping, J. Krüger, A. Janah: Effect of alcohol on genetically determined variants of the normal electroencephalogram. In: Psychiatry Res 2, 1980, pp. 85-98
  8. ↑ OK Steinlein, JC Mulley, P. Propping, et al: A missense mutation in the neuronal nicotinic acetylcholine receptor a4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. In: Nature Genetics, 11, 1995, pp. 201-203, PMID 7550350
  9. ↑ Ch. Biervert,. . . P. Propping, et al: A potassium channel mutation in neonatal human epilepsy. In: Science, 279, 1998, pp. 403-406, PMID 9430594
  10. ^ Cross-Disorder Group of the Psychiatric Genomics Consortium, SH Lee.,. . . P. Propping,. . et al: Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. In: Nature Genetics, 45, 2013, pp. 984-995
  11. ^ Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium: Psychiatric genome-wide association analyzes implicate neuronal, immune and histone pathways. In: Nature Neuroscience, 18, 2015, pp. 199-209.
  12. ↑ R. Caspari,. . . P. Propping: Familial adenomatous polyposis: mutation at codon 1309 and early onset of colon cancer. In: Lancet 343, 1994, pp. 629-632
  13. ↑ R. Caspari,. . . P. Propping: Familial adenomatous polyposis: desmoid tumors and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444. In: Human Molecular Genetics, 1995, 4, pp. 337-340
  14. ↑ E. Mangold,. . . P. Propping: Spectrum and frequencies of mutations in MSH2 and MLH1 in 1721 German families suspected of hereditary nonpolyposis colorectal cancer. In: International Journal of Cancer, 116, 2005, pp. 692-702
  15. ^ V. Steinke,. . . P. Propping et al .: Evaluating the performance of clinical criteria for predicting mismatch repair gene mutations in Lynch syndrome: a comprehensive analysis of 3,671 families. In: International Journal of Cancer, 135, 2014, pp. 69-77
  16. ↑ V. Steinke,. . . P. Propping: Hereditary nonpolyposis colorectal cancer (HNPCC) / Lynch syndrome. In: Deutsches Ärzteblatt International, 110, 2013, SS 32–38
  17. ↑ German Cancer Aid Prize for Peter Propping
  18. ↑ Member entry by Prof. Dr. Peter Propping (with picture) at the German Academy of Sciences Leopoldina , accessed on May 19, 2016.
  19. ↑ See Salary Regulations W # Reactions .
  20. ↑ High qualification , letters to the editors. In: Frankfurter Allgemeine Zeitung , September 11, 2008, p. 7
personal data
SURNAME Propping, Peter
BRIEF DESCRIPTION German human geneticist
DATE OF BIRTH December 21, 1942
PLACE OF BIRTH Berlin
DATE OF DEATH April 26, 2016
Place of death Bonn