Pindon

Structural formula
General
Surname	Pindon
other names	2- (2,2-Dimethylpropanoyl) -1 H -inden-1,3 (2 H ) -dione ( IUPAC ) ; 2- (2,2-dimethyl-1-oxopropyl) indan-1,3-dione; 2-pivaloylindane-1,3-dione;
Molecular formula	C 14 H 14 O 3
Brief description	yellow odorless powder
External identifiers / databases
EC number	201-462-8
ECHA InfoCard	100.001.330
PubChem	6732
ChemSpider	6476
Wikidata	Q2276931
properties
Molar mass	230.26 g mol −1
Physical state	firmly
density	1.06 g cm −3
Melting point	108.5-110.5 ° C
solubility	18 mg / l
safety instructions
H and P phrases	H: 301-372-410
	P: 260-264-273-301 + 310 + 330-314-391
MAK	Switzerland: 0.1 mg m −3 (measured as inhalable dust )
Toxicological data	280 mg kg ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Pindon is a chemical compound and is used to fight rats and other rodents . It belongs to the group of indane derivatives.

use

Like other indane derivatives such as chlorophacinone, pindone is used to control voles or to treat rabbits in garden areas.

effect

Pindon acts as an anticoagulant in rats and causes internal bleeding. Only large doses are fatal, whereby the fatal effect can have fatal consequences that lead to death. In terms of pharmacological effects, it has already been established that pindone is similar to the coumarin derivative warfarin , although pindone is more of the indane type. But it is mainly used to treat rabbits.

Toxicology and Antidote

Large oral doses cause profuse internal bleeding in humans, with fatal consequences. The lethal dose in rats is 280 mg / kg body weight. Typical symptoms of intoxication are: severe abdominal pain, headache, frequent bloody diarrhea, frequent blood-irritant coughing, cramps, broken bones, internal bleeding, natural feelings of suffocation and shortness of breath, which really occur. Most people die from internal bleeding and fatal kidney failure. Vitamin K is already used as an antidote for pindone poisoning.

Admission

Pindon was licensed in Germany from 1971 to 1986. Today it is not approved as a crop protection agent in the European Union or Switzerland .

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g Entry on pindon in the GESTIS substance database of the IFA , accessed on January 15, 2020(JavaScript required) .
↑ Entry on Pindone in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ Swiss Accident Insurance Fund (Suva): Limit values - current MAK and BAT values (search for 83-26-1 or Pindon ), accessed on November 2, 2015.
↑ approval history of the BVL
^ Directorate-General for Health and Food Safety of the European Commission: EU pesticide database ; Entry in the national directory of plant protection products in Switzerland ; Retrieved June 25, 2016.

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g Entry on pindon in the GESTIS substance database of the IFA , accessed on January 15, 2020(JavaScript required) .

[CLP_100.001.330-2] Entry on Pindone in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[3] Swiss Accident Insurance Fund (Suva): Limit values - current MAK and BAT values (search for 83-26-1 or Pindon ), accessed on November 2, 2015.

[historie-4] roval history of the BVL

[5] Directorate-General for Health and Food Safety of the European Commission: EU pesticide database ; Entry in the national directory of plant protection products in Switzerland ; Retrieved June 25, 2016.