Propoxur

Structural formula
General
Surname	Propoxur
other names	2-isopropoxyphenyl N -methyl carbamate; 2- (1-methylethoxy) phenyl methyl carbamate; Leaf anex; Rhodes; Baygon; Arprocarb; Unden;
Molecular formula	C 11 H 15 NO 3
Brief description	white to yellow-brown, crystalline solid with a characteristic phenol-like odor
External identifiers / databases
EC number	204-043-8
ECHA InfoCard	100.003.676
PubChem	4944
ChemSpider	4775
Wikidata	Q411303
properties
Molar mass	209.24 g mol −1
Physical state	firmly
density	1.12 g cm −3 (20 ° C)
Melting point	90.7 ° C
solubility	heavy in water (1.9 g l −1 at 20 ° C); soluble in acetone and methanol ;
safety instructions
H and P phrases	H: 300 + 330-311-410
	P: 260-280-301 + 330 + 331 + 310-302 + 352 + 312-304 + 340 + 310-403 + 233
MAK	DFG : 2 mg m −3 ; Switzerland: 0.5 mg m −3 (measured as inhalable dust );
Toxicological data	41 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Propoxur is an insecticide and acaricide that is used as a food or contact poison and belongs to the class of carbamates .

history

The compound was brought to market in 1961 by the chemical company Bayer AG .

Related compounds and synthesis

A derived compound is 2-isopropoxyphenol (C ₉ H ₁₂ O ₂ , CAS number: 4812-20-8), from which the active ingredient propoxur can be synthesized by adding methyl isocyanate with the catalytic aid of triethylamine .

use

Propoxur was used, among other things, as a pesticide in agriculture and in the home, as well as an agent against fleas in dogs and cats (dosage forms include powder, collars, sprays and shampoo).

Admission

Decision 2009/324 / EC of the European Commission of April 14, 2009, which was passed within the framework of European biocide legislation, has been in force since June 1, 2009. It decided not to include the active ingredient Propoxur for product type 18 (insecticides, acaricides and products against other arthropods). A sell-off period of 12 months was granted, which ended on May 31, 2010. Since this date, biocidal products that contain propoxur and belong to product type 18 may no longer be placed on the market.

In Germany, Austria and Switzerland there is no approval as a plant protection product.

toxicology

The mean lethal dose (LD ₅₀ ) for rats ingested orally is around 41 mg per kilogram of body weight. Overdosing may cause neurological symptoms in treated animals. The antidote is atropine .

There are no reports on the carcinogenic effects of Propoxur. In animal experiments, Propoxur showed a teratogenic effect at high doses .

Trade names

Kiltix, Bolfo, Trixie

Individual evidence

↑ ^a ^b ^c Entry Proxopur at Enius, accessed on May 13, 2017.
↑ ^a ^b ^c ^d ^e ^f Entry on Propoxur in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .
↑ Entry on Propoxur in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ Swiss Accident Insurance Fund (Suva): Limit values - current MAK and BAT values (search for 114-26-1 or Propoxur ), accessed on November 2, 2015.
↑ Propoxur data sheet from Sigma-Aldrich , accessed on May 13, 2017 ( PDF ).

↑ Decision of the Commission of April 14, 2009 on the non-inclusion of certain active substances in Annex I, IA or IB of Directive 98/8 / EC of the European Parliament and of the Council on the placing of biocidal products on the market .

↑ General Directorate Health and Food Safety of the European Commission: Entry on fenitrothion in the EU pesticide database; Entry in the national registers of plant protection products in Austria and Germany ; Retrieved March 3, 2016.

↑ entry to propoxur in Vetpharm, accessed on August 5 2012th

↑ EXTOXNET: Propoxur . As of June 1996.

[enius-1] Entry Proxopur at Enius, accessed on May 13, 2017.

[GESTIS-2] ↑ ^a ^b ^c ^d ^e ^f Entry on Propoxur in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .

[CLP_100.003.676-3] Entry on Propoxur in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[4] Swiss Accident Insurance Fund (Suva): Limit values - current MAK and BAT values (search for 114-26-1 or Propoxur ), accessed on November 2, 2015.

[Sigma-5] Propoxur data sheet from Sigma-Aldrich , accessed on May 13, 2017 ( PDF ).

[6] Decision of the Commission of April 14, 2009 on the non-inclusion of certain active substances in Annex I, IA or IB of Directive 98/8 / EC of the European Parliament and of the Council on the placing of biocidal products on the market .

[PSM-7] General Directorate Health and Food Safety of the European Commission: Entry on fenitrothion in the EU pesticide database; Entry in the national registers of plant protection products in Austria and Germany ; Retrieved March 3, 2016.

[8] try to propoxur in Vetpharm, accessed on August 5 2012th

[9] EXTOXNET: Propoxur . As of June 1996.