Pyrrole nitrine

Structural formula
General
Non-proprietary name	Pyrrole nitrine
other names	3-chloro-4- (3-chloro-2-nitrophenyl) -1 H -pyrrole ( IUPAC )
Molecular formula	C 10 H 6 Cl 2 N 2 O 2
External identifiers / databases
CAS number 1018-71-9 EC number 213-812-7 ECHA InfoCard 100.012.557 PubChem 13916 Wikidata Q371817
Drug information
ATC code	D01 AA07
Drug class	antibiotic Antifungal agent
properties
Molar mass	257.07 g · mol -1
Physical state	firmly
Melting point	124.5 ° C
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS labeling of hazardous substances Caution H and P phrases H: 315-319-335 P: 261-305 + 351 + 338
Toxicological data	> 2000 mg kg −1 ( LD 50 ,  rat ,  oral ) 86 mg kg −1 ( LD 50 ,  mouse ,  ip )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Pyrrole nitrine is a chemical compound from the group of pyrrole derivatives.

use

Pyrrole nitrine is an antifungal antibiotic that was isolated from the bacterium Pseudomonas pyrrocinia . It is effective against various types of pathogenic fungi, including a .:

• Trichophyton rubrum
• Trichophyton mentagrophytes
• Trichophyton tonsurans

(see Trichophyton )

• Microsporum audouini
• Epidermophyton floccosum
• Malassezia furfur

It blocks the electron transport between succinate or reduced NADH and coenzyme Q .

Its application is topical (local).

Individual evidence

1. ↑ ^{a b c} Entry on pyrrole nitrine in the ChemIDplus database of the United States National Library of Medicine (NLM) .
2. ↑ ^{a b c} Datasheet Pyrrolnitrin from Pseudomonas cepacia at Sigma-Aldrich , accessed on April 22, 2011 ( PDF ).
3. ↑ Micutrin ^® : Riassunto delle Caratteristiche del Prodotto (Summary of Product Characteristics), Pharmacia Italia SpA as of March 2002.

Trade names

Micutrin (Italy, except sales)

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !