Roxarson

Structural formula
General
Surname	Roxarson
other names	Hydroxyphenylarsonic acid; 4-Hydroxy-3-nitro-benzene-1-arsonic acid;
Molecular formula	C 6 H 6 AsNO 6
Brief description	yellow solid
External identifiers / databases
EC number	204-453-7
ECHA InfoCard	100.004.049
PubChem	5104
Wikidata	Q3049725
properties
Molar mass	263.04 g mol −1
Physical state	firmly
Melting point	> 300 ° C
solubility	poorly soluble in cold water; Easily soluble in acetic acid , acetone and alkalis ; sparingly soluble in dilute mineral acids ; insoluble in ethyl acetate ;
safety instructions
H and P phrases	H: 301-331-410
	P: 261-273-301 + 310-311-501
Toxicological data	81 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Roxarson is a chemical compound from the group of phenylarsonic acid derivatives that was discovered in 1941.

Extraction and presentation

Roxarson can be obtained by reacting sodium 4-hydroxyphenyl arsonate with sulfuric and nitric acid.

properties

Roxarson is a crystalline yellow solid. It decomposes when heated, producing nitrogen oxides and arsenic (III) oxide , among other things . The substance forms a mono-, di- and tri-sodium salt.

use

Roxarson is used as a veterinary growth stimulant (for pig and poultry feed) and for enteric infections, formerly for the production of arsphenamines and as a precipitation reagent of zirconium . Use in food-producing animals is banned in Europe, but allowed in the US and other countries.

literature

Gladys S. Bayse, Latanya P. Hammonds-Odie, Kimberly M. Jackson, Deidre K. Tucker, Ward G. Kirlin: Permeation of roxarsone and its metabolites increases caco-2 cell proliferation. In: Advances in Biological Chemistry , 2013, 3 (4), p. 389, doi : 10.4236 / abc.2013.34041 .

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g Entry on Roxarson in the GESTIS substance database of the IFA , accessed on September 29, 2017(JavaScript required) .
↑ ^a ^b ^c ^d ^e ^f Paul Heinz List, Ludwig Hörhammer: Chemicals and Drugs Part B: R, S . Springer-Verlag, 2013, ISBN 978-3-642-66377-2 , pp. 178 ( limited preview in Google Book search).
^ Steeve Giguere, John F. Prescott, Patricia M. Dowling: Antimicrobial Therapy in Veterinary Medicine . John Wiley & Sons, 2013, ISBN 978-1-118-67507-6 ( limited preview in Google Book Search).
^ J. Buckingham: Dictionary of Organic Compounds . CRC Press, 1985, ISBN 978-0-412-54090-5 , pp. 3760 ( limited preview in Google Book search).
↑ Spectrum of Science: Environmental Chemistry: Fattening Agent Responsible for Arsenic in Groundwater - Spectrum of Science , accessed on September 29, 2017.
↑ EU: Extract from the report of the Food and Veterinary Office on the inspection visit to South Africa , June 12-21, 2007
↑ Questions and Answers Regarding 3-Nitro (Roxarsone) "> Product Safety Information> Questions and Answers Regarding 3-Nitro (Roxarsone): Product Safety Information> Questions and Answers Regarding 3-Nitro (Roxarsone) , accessed on September 29, 2017.

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g Entry on Roxarson in the GESTIS substance database of the IFA , accessed on September 29, 2017(JavaScript required) .

[Paul_Heinz_List,_Ludwig_Hörhammer-2] ↑ ^a ^b ^c ^d ^e ^f Paul Heinz List, Ludwig Hörhammer: Chemicals and Drugs Part B: R, S . Springer-Verlag, 2013, ISBN 978-3-642-66377-2 , pp. 178 ( limited preview in Google Book search).

[Steeve_Giguere,_John_F._Prescott,_Patricia_M._Dowling-3] Steeve Giguere, John F. Prescott, Patricia M. Dowling: Antimicrobial Therapy in Veterinary Medicine . John Wiley & Sons, 2013, ISBN 978-1-118-67507-6 ( limited preview in Google Book Search).

[J._Buckingham-4] J. Buckingham: Dictionary of Organic Compounds . CRC Press, 1985, ISBN 978-0-412-54090-5 , pp. 3760 ( limited preview in Google Book search).

[Spektrum_der_Wissenschaft-5] Spectrum of Science: Environmental Chemistry: Fattening Agent Responsible for Arsenic in Groundwater - Spectrum of Science , accessed on September 29, 2017.

[EU-6] EU: Extract from the report of the Food and Veterinary Office on the inspection visit to South Africa , June 12-21, 2007

[Product_Safety_Information-7] Questions and Answers Regarding 3-Nitro (Roxarsone) "> Product Safety Information> Questions and Answers Regarding 3-Nitro (Roxarsone): Product Safety Information> Questions and Answers Regarding 3-Nitro (Roxarsone) , accessed on September 29, 2017.