Sérgio Henrique Ferreira

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Sérgio Henrique Ferreira (born October 4, 1934 in Franca , state of Sao Paulo , Brazil ; † July 17, 2016 in Ribeirão Preto , state of Sao Paulo) was a Brazilian pharmacologist and doctor.

Ferreira studied at the University of Sao Paulo (USP) at the Medical Faculty in Ribeirão Preto. He did research there with Mauricio Rocha e Silva (the discoverer of bradykinin ) in pharmacology. There he discovered peptides in the venom of the Jararaca lance viper (Bothrops jararaca), which significantly increased the effect of bradykinin (bradykinin potentiating factor, BPF). In 1968, in collaboration with Lewis Joel Greene from the Brookhaven National Laboratory , he was able to characterize the BPF peptides more precisely and clarify their structure. It suppresses angiotensin I conversion (via the angiotensin converting enzyme , ACE). This ultimately led to the development of the first ACE inhibitors at the pharmaceutical company Bristol-Myers Squibb ( Captopril ).

In the early 1970s Ferreira was in London, where he worked with John R. Vane on the mode of action of non- steroidal painkillers ( analgesics or NSAIDs, non-steroidal anti-inflammatory drugs) that have anti-inflammatory effects. Back then, he was also involved in Vane's research, which clarified the mechanism of ASA (suppression of prostaglandin synthesis by Cox inhibition) and for which Vane received the Nobel Prize. He further clarified the effect of analgesics such as Metamizol (Novalgin) - they counteract the irritation of the primary sensory cells via the nitric oxide axis.

His group also clarified the role of various cytokines in inflammation.

Ferreira has been researching at the Institute of Pharmacology at the University of Sao Paulo in Ribeirão Preto since 1961, where he is a professor.

In 1983 Ferreira received the CIBA Prize for Hypertension Research with Miguel Ondetti and David Cushman from Squibb and in 1995 the National Order for Merit to Science (Grand Cross level) of Brazil. Other prizes were: the Mexican Prize for Science and Technology, the Rheimboldt-Hauptmann Prize of the University of Sao Paulo (2001), the Prize of the Third World Academy of Science, the Péter Murányi Prize (2002) and the Prince Mahidol Prize in 2008 . Ferreira is an external member of the National Academy of Sciences , member of the Brazilian Academy of Sciences and the Brazilian Council for Science and Technology . He is the founder and past president of the Brazilian Society for Pharmacology and Therapeutics and the Brazilian Society for the Advancement of Science (SBPC).

Fonts

  • Ferreira A Bradykinin Potentiating Factor (BPF) present in the venom of Bothrops Jararaca , British J. Pharmacology Chemotherapy , February 24, 1965, pp. 163-169, PMC 1704050 (free full text)
  • Ferreira, Moncada, Vane Prostaglandins and the mechanism of analgesia produced by aspirin like drugs , British J. Pharmacology, Volume 49, 1973, pp. 86-97
  • Ferreira Prostaglandins, aspirin-like drugs and analgesia , Nature New Biology, Volume 240, 1972, pp. 200-203.
  • Ferreira, M. Nakamura II-Prostaglandins hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists , Prostaglandins, Volume 18, 1979, pp. 191-200.
  • Ferreira et al. a. Interleukin-1b as a potent hyperalgesic agent antagonized by a tripeptide analogue , Nature , Volume 334, 1988, pp. 698-700
  • Ferreira et al. a. The molecular mechanism of action of peripheral morphine analgesia: stimulation of cGMP system via nitric oxide release , European Journal of Pharmacology , Volume 201, 1991, pp 121-122.
  • Ferreira, Lorenzetti, S. Poole Bradykinin initiates cytokine mediated inflammatory hyperalgesia , Brazilian Journal of Pharmacological Sciences, Volume 110, 1993, pp. 1227-1231
  • Ferreira, BB Lorenzetti Glutamate spinal retrograde sensitization of primary sensory neurons associated with nociception , Neuropharmacology , Volume 33, 1994, pp. 1479-1485, PMID 7532832

Web links

Individual evidence

  1. ↑ Morre cientista Sergio Henrique Ferreira, aos 81 anos Estadão. Retrieved July 20, 2016.
  2. ↑ Ondetti, Cushman History of the design of captopril and related inhibitors of angiotensin converting enzyme , Hypertension, Volume 17, 1991, p. 589.Smith, Vane The discovery of Captopril , FASEB Journal , Volume 17, 2003, p. 788.
  3. ↑ Lorenzetti, Ferreira Activation of arginine-nitric oxide pathway in primary sensory neurons contributes in dipyrone-induced spinal and peripheral analgesia , Inflamm. Res., Volume 45, 1996, p. 308.
personal data
SURNAME Ferreira, Sérgio Henrique
BRIEF DESCRIPTION Brazilian pharmacologist and doctor
DATE OF BIRTH 4th October 1934
PLACE OF BIRTH Franca , State of Sao Paulo , Brazil
DATE OF DEATH 17th July 2016
Place of death Ribeirão Preto , State of Sao Paulo