Tribufos

Structural formula
General
Surname	Tribufos
other names	1,2,4-tributyl phosphorotrithioate; S , S , S -Tributyl trithiophosphate; DEF; Butiphos;
Molecular formula	C 12 H 27 OPS 3
Brief description	colorless to light yellow liquid
External identifiers / databases
EC number	201-120-8
ECHA InfoCard	100.001.019
PubChem	5125
Wikidata	Q2537076
properties
Molar mass	314.51 g mol −1
Physical state	liquid
density	1.06 g cm −3 (bulk density)
Melting point	−25 ° C
solubility	practically insoluble in water (2.3 mg l −1 at 20 ° C)
safety instructions
H and P phrases	H: 301-310-410
	P: 273-280-301 + 310-302 + 350-310-501
Toxicological data	234 mg kg −1 ( LD 50 , rat , oral ) ; 850 mg kg −1 ( LD 50 , rabbit , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Tribufos is a chemical compound from the group of thiophosphoric acid esters . It was patented by the Pittsburgh Coke And Chemical Company in 1960.

Extraction and presentation

Tribufos can be obtained by thio-alkylating phosphorus trichloride with 1-butanethiol and hydrogen peroxide .

use

Tribufos is used as a defoliant in cotton cultivation. In addition, it acts as a synergist by inhibiting esterases .

Admission

The EU Commission decided in 2002 not to include Tribufos in the list of permissible active ingredients in plant protection products. In Switzerland, too, no pesticides containing this active ingredient are permitted.

Individual evidence

↑ ^a ^b ^c ^d ^e ^f Entry on Tribufos in the Pesticide Properties DataBase (PPDB) of the University of Hertfordshire , accessed on March 20, 2014.
↑ ^a ^b ^c data sheet 1,2,4-tributyl phosphorotrithioate, analytical standard from Sigma-Aldrich , accessed on March 20, 2014 ( PDF ).
↑ Patent US2965467A : Method of defoliating plants. Filed on October 16, 1956 , published on December 20, 1960 , Applicant: Pittsburgh Coke And Chemical Company, inventor Markley Francis X.
↑ Shenyang Chemical Industry: Synthesis of Higher Pure Tribufos And Research of Its Impurity , accessed May 2, 2014.
↑ Regulation (EC) No. 2076/2002 of the Commission of November 20, 2002 (PDF) extending the deadline according to Article 8 (2) of Council Directive 91/414 / EEC and on the non-inclusion of certain active substances in Annex I of this Directive and the revocation of the approval of plant protection products with these active substances.
↑ General Directorate Health and Food Safety of the European Commission: Entry on Tribufos (s, s, s-tributyl-phosphorotrithioate) in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 26, 2016.

[ppdb-1] ↑ ^a ^b ^c ^d ^e ^f Entry on Tribufos in the Pesticide Properties DataBase (PPDB) of the University of Hertfordshire , accessed on March 20, 2014.

[Sigma-2] ta sheet 1,2,4-tributyl phosphorotrithioate, analytical standard from Sigma-Aldrich , accessed on March 20, 2014 ( PDF ).

[3] Patent US2965467A : Method of defoliating plants. Filed on October 16, 1956 , published on December 20, 1960 , Applicant: Pittsburgh Coke And Chemical Company, inventor Markley Francis X.

[cnki.com.cn-4] Shenyang Chemical Industry: Synthesis of Higher Pure Tribufos And Research of Its Impurity , accessed May 2, 2014.

[5] Regulation (EC) No. 2076/2002 of the Commission of November 20, 2002 (PDF) extending the deadline according to Article 8 (2) of Council Directive 91/414 / EEC and on the non-inclusion of certain active substances in Annex I of this Directive and the revocation of the approval of plant protection products with these active substances.

[6] General Directorate Health and Food Safety of the European Commission: Entry on Tribufos (s, s, s-tributyl-phosphorotrithioate) in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 26, 2016.