Thiobarbital

Structural formula
General
Non-proprietary name	Thiobarbital
other names	5,5-Diethyldihydro-2-thioxo (1 H , 5 H ) -pyrimidine-4,6-dione
Molecular formula	C 8 H 12 N 2 O 2 S
Brief description	pale yellow needles
External identifiers / databases
CAS number 77-32-7 EC number 201-020-4 ECHA InfoCard 100,000,929 PubChem 667509 ChemSpider 580885 Wikidata Q2421278
Drug information
Drug class	Barbiturates , sedatives
properties
Molar mass	200.26 g · mol -1
Physical state	firmly
Melting point	180 ° C
solubility	almost insoluble in benzene soluble in ethanol , chloroform , diethyl ether and alkaline solutions
safety instructions
GHS hazard labeling no classification available
Toxicological data	175 mg kg −1 ( LD Lo ,  rat ,  ip )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Thiobarbital is a moderately effective barbiturate with a predominantly hypnotic effect. Structurally, it is a derivative of barbituric acid , but one keto oxygen atom has been replaced by sulfur ( thiobarbiturate ); this is the only difference from its analogue barbital . In Germany, drugs based on thiobarbital are not permitted in human or veterinary medicine.

Effect, metabolism and use

Thiobarbital - like pentobarbital - has an analgesic effect in addition to the sleep-inducing effect. It is also a thyroid inhibitor. In animal experiments, impairment of kidney function occurred. When metabolized in the body, oxidative desulfuration takes place, with thiobarbital forming barbital.

Thiobarbital is used as a detection reagent for the colorimetric determination of nicotine metabolites.

Individual evidence

1. ↑ ^{a b c d e f} C. R. Ganellin, David J. Triggle: Dictionary of pharmacological agents. Volume 1: A – G. Chapman & Hall / CRC Press, 1997, ISBN 0-412-46630-9 , p. 638.
2. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
3. ^ Journal of Pharmacology and Experimental Therapeutics . Vol. 97, Pg. 478, 1949.
4. ↑ Entry on thiobarbital in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on November 28, 2018.
5. ↑ Richard E. Fish (Ed.), Peggy J. Danneman (Ed.), Marilyn Brown (Ed.), Alicia Karas (Ed.): Anesthesia and analgesia in laboratory animals. 2nd edition, 2008, ISBN 978-0-12-373898-1 , p. 260.
6. ↑ SS Deshpande: Handbook of food toxicology. Volume 119, CRC Press, 2002, ISBN 0-8247-0760-5 , p. 95.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !