Zinc acetate

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Structural formula
Zinc ion 2Acetate ion
General
Surname Zinc acetate
other names
  • E  650
  • ZINC ACETATE ( INCI )
Molecular formula C 4 H 6 O 4 Zn (anhydrous)
Brief description

white solid with a faint odor of acetic acid

External identifiers / databases
CAS number
  • 557-34-6 (anhydrous)
  • 5970-45-6 (dihydrate)
PubChem 11192
Wikidata Q204639
Drug information
ATC code

A16 AX05

properties
Molar mass
  • 183.48 g mol −1 (anhydrous)
  • 219.50 g mol −1 (dihydrate)
Physical state

firmly

density
  • 1.74 g cm −3 (dihydrate)
  • 1.84 g cm −3 (anhydrous, 25 ° C)
Melting point

237 ° C

solubility
  • good in water (430 g l −1 )
  • very good in DMSO (> 1000 g l −1 )
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
05 - Corrosive 07 - Warning 09 - Dangerous for the environment

danger

H and P phrases H: 302-318-410
P: 280-301 + 312 + 330-305 + 351 + 338 + 310
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Zinc acetate is the zinc salt of acetic acid with the structural formula Zn (CH 3 COO) 2 , which in chewing gum as a flavor enhancer used and there with the number E E is in the 650th Zinc acetate is a zinc compound that is well absorbed from the intestines into the bloodstream . Thus, among other things, it serves as a supplier of zinc for the organism.

Extraction and presentation

Zinc (II) acetate can be prepared by reaction of zinc oxide or zinc carbonate with acetic acid are produced.

The direct synthesis of the anhydrous salt takes place in the laboratory via the conversion of zinc nitrate with an excess of acetic anhydride to remove the water that is formed after:

properties

Basic zinc acetate

When Zn (CH 3 COO) 2 is heated in vacuo, acetic anhydride is split off and a “basic zinc acetate” with the formula Zn 4 O (CH 3 COO) 6 is formed . The cluster compound shown below is formed with a tetrahedral structure that is similar to the analogous beryllium salt.

use

Zinc acetate is only approved as a flavor enhancer in chewing gum. The amount of zinc acetate in the chewing gum mass is limited to 1 g / kg.

Similar to zinc gluconate , zinc acetate is said to shorten the duration of colds when administered in cough drops through a local effect in the throat.

A suspension of 5 g zinc acetate in 100 mL 90% ethanol (Schlesinger reagent) is used, among other things, in thin layer chromatography to detect urobilins and stercobilin . The fluorescence that occurs with a positive reaction can be viewed in UV light.

Individual evidence

  1. Entry on E 650: Zinc acetate in the European database on food additives, accessed on June 27, 2020.
  2. Entry on ZINC ACETATE in the CosIng database of the EU Commission, accessed on March 11, 2020.
  3. a b c d e f g Entry on zinc acetate in the GESTIS substance database of the IFA , accessed on January 9, 2019(JavaScript required) .
  4. ^ Gaylord Chemical Company, LLC; Bulletin 102: Dimethyl Sulfoxide (DMSO) Solubility Data. June 2014, p. 15.
  5. Georg Brauer: Zinc acetate . In: Handbook of Preparative Inorganic Chemistry . Ferdinand Enke Verlag, Stuttgart 1954, p. 806 .
  6. Hirozo Koyama, Yoshihiko Saito: The Crystal Structure of Zinc Oxyacetate, Zn 4 O (CH 3 COO) 6 . In: Bulletin of the Chemical Society of Japan . tape 27 , no. January 2 , 1954, p. 112-114 , doi : 10.1246 / bcsj.27.112 .
  7. Regulation (EC) No. 1333/2008 of the European Parliament and of the Council of December 16, 2008 on food additives (PDF; 3.6 MB), accessed on July 29, 2016 .
  8. G. Eby: Zinc Lozenges: Cold Cure or Candy? Solution Chemistry Determinations , Bioscience Reports, 2004, Volume 24, No.1, February 2004. German report on the publication .
  9. E. Merck AG (Ed.): Staining reagents for thin-layer and paper chromatography . Darmstadt 1965, p. 57 .