FOXD4: Difference between revisions

FOXD4
Identifiers
Aliases	FOXD4, FKHL9, FOXD4A, FREAC-5, FREAC5, forkhead box D4
External IDs	OMIM: 601092 MGI: 1347467 HomoloGene: 83248 GeneCards: FOXD4
Gene location (Human)
Chr.	Chromosome 9 (human)
End	118,417 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	24,878,561 bp
RNA expression pattern
	Top expressed in
	cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; prefrontal cortex; ; putamen; ; stromal cell of endometrium; ; caudate nucleus; ; hypothalamus; ; hippocampus proper; ; dorsolateral prefrontal cortex;
	Top expressed in
	hypoblast; ; red nucleus; ; endoderm; ; notochord; ; spermatocyte; ; mesoderm; ; spinal ganglia; ; spinal cord; ; blood; ; hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; DNA binding, bending; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	2298
	14237
	ENSG00000170122
	ENSMUSG00000051490
	Q12950
	Q60688
	NM_207305
	NM_008022
	NP_997188
	NP_032048
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 06:52, 22 December 2023

Forkhead box protein D4 is a protein that in humans is encoded by the FOXD4 gene.^[5]^[6]^[7]^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170122 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051490 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pierrou S, Hellqvist M, Samuelsson L, Enerback S, Carlsson P (Dec 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". EMBO J. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.
^ Larsson C, Hellqvist M, Pierrou S, White I, Enerback S, Carlsson P (Feb 1997). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics. 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID 8825632.
^ Freyaldenhoven BS, Fried C, Wielckens K (Sep 2002). "FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines". Gene. 294 (1–2): 131–140. doi:10.1016/S0378-1119(02)00702-3. PMID 12234674.
^ "Entrez Gene: FOXD4 forkhead box D4".

Further reading[edit]

Cederberg A, Betz R, Lagercrantz S, et al. (1997). "Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene". Genomics. 44 (3): 344–6. doi:10.1006/geno.1997.4864. PMID 9325056.
Fan Y, Newman T, Linardopoulou E, Trask BJ (2003). "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions". Genome Res. 12 (11): 1663–72. doi:10.1101/gr.338402. PMC 187549. PMID 12421752.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Minoretti P, Arra M, Emanuele E, et al. (2007). "A W148R mutation in the human FOXD4 gene segregating with dilated cardiomyopathy, obsessive-compulsive disorder, and suicidality". Int. J. Mol. Med. 19 (3): 369–72. doi:10.3892/ijmm.19.3.369. PMID 17273782.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170122 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051490 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7957066-5] Pierrou S, Hellqvist M, Samuelsson L, Enerback S, Carlsson P (Dec 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". EMBO J. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.

[pmid8825632-6] Larsson C, Hellqvist M, Pierrou S, White I, Enerback S, Carlsson P (Feb 1997). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics. 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID 8825632.

[pmid12234674-7] Freyaldenhoven BS, Fried C, Wielckens K (Sep 2002). "FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines". Gene. 294 (1–2): 131–140. doi:10.1016/S0378-1119(02)00702-3. PMID 12234674.

[entrez-8] "Entrez Gene: FOXD4 forkhead box D4".

[1]

[2]

[3]

[4]

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=2298}}
+{{Infobox_gene}}
-'''Forkhead box protein D4''' is a [[protein]] that in humans is encoded by the ''FOXD4'' [[gene]].<ref name="pmid7957066">{{cite journal | author = Pierrou S, Hellqvist M, Samuelsson L, Enerback S, Carlsson P | title = Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending | journal = EMBO J | volume = 13 | issue = 20 | pages = 5002–12 | year = 1994 | month = Dec | pmid = 7957066 | pmc = 395442 | doi =  }}</ref><ref name="pmid8825632">{{cite journal | author = Larsson C, Hellqvist M, Pierrou S, White I, Enerback S, Carlsson P | title = Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12) | journal = Genomics | volume = 30 | issue = 3 | pages = 464–9 | year = 1997 | month = Feb | pmid = 8825632 | pmc =  | doi = 10.1006/geno.1995.1266 }}</ref><ref name="pmid12234674">{{cite journal | author = Freyaldenhoven BS, Fried C, Wielckens K | title = FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines | journal = Gene | volume = 294 | issue = 1-2 | pages = 131–140 | year = 2002 | month = Sep | pmid = 12234674 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FOXD4 forkhead box D4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2298| accessdate = }}</ref>
+'''Forkhead box protein D4''' is a [[protein]] that in [[Human|humans]] is encoded by the ''FOXD4'' [[gene]].<ref name="pmid7957066">{{cite journal | vauthors = Pierrou S, Hellqvist M, Samuelsson L, Enerback S, Carlsson P | title = Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending | journal = EMBO J | volume = 13 | issue = 20 | pages = 5002–12 |date=Dec 1994 | pmid = 7957066 | pmc = 395442 | doi =  10.1002/j.1460-2075.1994.tb06827.x}}</ref><ref name="pmid8825632">{{cite journal | vauthors = Larsson C, Hellqvist M, Pierrou S, White I, Enerback S, Carlsson P | title = Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12) | journal = Genomics | volume = 30 | issue = 3 | pages = 464–9 |date=Feb 1997 | pmid = 8825632 | doi = 10.1006/geno.1995.1266 }}</ref><ref name="pmid12234674">{{cite journal | vauthors = Freyaldenhoven BS, Fried C, Wielckens K | title = FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines | journal = Gene | volume = 294 | issue = 1–2 | pages = 131–140 |date=Sep 2002 | pmid = 12234674 | doi =10.1016/S0378-1119(02)00702-3  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FOXD4 forkhead box D4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2298}}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
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-}}
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  | vauthors=Cederberg A, Betz R, Lagercrantz S |title=Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene. |journal=Genomics |volume=44 |issue= 3 |pages= 344–6 |year= 1997 |pmid= 9325056 |doi= 10.1006/geno.1997.4864 |display-authors=etal}}
-{{PBB_Further_reading
+*{{cite journal  | vauthors=Fan Y, Newman T, Linardopoulou E, Trask BJ |title=Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1663–72 |year= 2003 |pmid= 12421752 |doi= 10.1101/gr.338402  | pmc=187549 }}
-| citations =
-*{{cite journal  | author=Cederberg A, Betz R, Lagercrantz S, ''et al.'' |title=Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene. |journal=Genomics |volume=44 |issue= 3 |pages= 344–6 |year= 1997 |pmid= 9325056 |doi= 10.1006/geno.1997.4864 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal |bibcode=2002PNAS...9916899M|doi-access=free }}
-*{{cite journal  | author=Fan Y, Newman T, Linardopoulou E, Trask BJ |title=Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1663–72 |year= 2003 |pmid= 12421752 |doi= 10.1101/gr.338402  | pmc=187549 }}
+*{{cite journal  | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465  | pmc=2734081 |bibcode=2004Natur.429..369H |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465  | pmc=2734081 }}
+*{{cite journal  | vauthors=Minoretti P, Arra M, Emanuele E |title=A W148R mutation in the human FOXD4 gene segregating with dilated cardiomyopathy, obsessive-compulsive disorder, and suicidality. |journal=Int. J. Mol. Med. |volume=19 |issue= 3 |pages= 369–72 |year= 2007 |pmid= 17273782 |doi=  10.3892/ijmm.19.3.369|display-authors=etal|doi-access=free }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Minoretti P, Arra M, Emanuele E, ''et al.'' |title=A W148R mutation in the human FOXD4 gene segregating with dilated cardiomyopathy, obsessive-compulsive disorder, and suicidality. |journal=Int. J. Mol. Med. |volume=19 |issue= 3 |pages= 369–72 |year= 2007 |pmid= 17273782 |doi=  }}
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 {{refend}}
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