Aglepriston

Structural formula
General
Non-proprietary name	Aglepriston
other names	11 β - [ p - (dimethylamino) phenyl] -17 β -hydroxy-17 α - ( Z ) - (1-propyenyl) estra-4,9-dien-3-one
Molecular formula	C 29 H 37 NO 2
External identifiers / databases
EC number	685-671-3
ECHA InfoCard	100.211.372
PubChem	6443220
ChemSpider	4947248
Wikidata	Q394224
Drug information
ATC code	Q G03XB90
Drug class	Antiprogestin
properties
Molar mass	431.61 g · mol -1
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances danger
H and P phrases	H: 360
	P: ?
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Aglepriston (trade name Alizin ^® ad us. Vet. ) Is a synthetic antihormone used in veterinary medicine . It is a derivative of the mifepristone used in human medicine .

Mode of action

The preparation is approved for dogs and cats .

Aglepristone is a so-called antiprogestin , a hormone-like steroid , which has a high binding ability ( affinity ) of progesterone - receptors , but no effect has progesterone. Because it blocks the receptors for this hormone in the womb ( uterus ), it cannot achieve its pregnancy- sustaining effects. The blood level of progesterone is not affected.

use

dog

The drug is used in dogs to prevent embryos from being embedded in the uterus ( prevention of nidation) or to terminate unwanted pregnancy (artificial abortion ). The latter is 100% certain up to the 25th day of pregnancy and possible up to the 45th day of pregnancy.

In addition, Aglepriston can be used to induce childbirth from the 48th day of pregnancy.

The drug is also suitable for the conservative treatment of purulent uterine inflammation ( pyometra ). It leads to an opening of the cervix ( cervix uteri ) and due to the increased motility of the uterus, the pus is expelled . After one to three weeks, the uterus is completely emptied. For conservative pyometra treatment, multiple doses and the additional administration of broad-spectrum antibiotics are necessary. In the case of cystic hyperplasia of the endometrium , this can be aggravated by the drug. In addition, Aglepriston only works safely in metestrus (progesterone value> 1.5 ng / ml, no superficial cells and clods in vaginal cytology ), but not in the presence of follicular cysts and in anoestrus.

cat

In cats, Aglepriston can also be used for conservative pyometry treatment. It can also be used to treat feline fibroadenomatosis ( hyperplasia of the breasts ).

Individual evidence

↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of [No public or meaningful name is available] in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on December 16, 2019, is derived from a self-classification by the distributor .
↑ Axel Wehrend: Key symptoms of gynecology and obstetrics in dogs. Enke Stuttgart 2010, ISBN 978-3-83-041076-8 , pp. 104-106.

Web links

Entry to aglepristone at Vetpharm

[1] Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of [No public or meaningful name is available] in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on December 16, 2019, is derived from a self-classification by the distributor .

[2] Axel Wehrend: Key symptoms of gynecology and obstetrics in dogs. Enke Stuttgart 2010, ISBN 978-3-83-041076-8 , pp. 104-106.