Carbocromene

Structural formula
General
Surname	Carbocromene
other names	Chromonary; Intercordin; Intensain; 3- (2-Diethylaminoethyl) -7- (ethoxycarbonylmethoxy) -4-methyl-2 H -1-benzopyran-2-one; Ethyl 2 - ({3- [2- (diethylamino) ethyl] -4-methyl-2-oxo-2 H -chromen-7-yl} oxy) acetate;
Molecular formula	C 20 H 27 NO 5
External identifiers / databases
EC number	212-356-6
ECHA InfoCard	100.011.233
PubChem	12604
ChemSpider	12084
Wikidata	Q5037872
Drug information
ATC code	C01 DX05
properties
Molar mass	361.43 g mol −1
Melting point	159-160 ° C
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling ; no classification available
Toxicological data	35.5 mg kg −1 ( LD 50 , mouse , iv ) ; 6200 mg kg −1 ( LD 50 , mouse , oral ) ; 528 mg kg −1 ( LD 50 , mouse , ip ) ; 8000 mg kg −1 ( LD 50 , rat , oral ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Carbocromene is a chemical compound from the group of coumarins and chromenes . It is a derivative of visnadine and its main metabolite is carbocromenic acid .

Extraction and presentation

Carbocromen can be obtained by reacting 3β-diethylaminoethyl-4-methyl-7-hydroxycoumarin chlorohydrate with ethyl bromoacetate in methyl ethyl ketone with potassium carbonate .

pharmacology

The bioavailability is 30–50%, the half-life is one to one and a half hours, 50–70% is excreted in the stool and 30–50% in the urine .

use

Carbocromen, in the form of its hydrochloride, is used as a coronary dilator for the treatment of mild forms of angina pectoris and was patented as a coronary dilator by Cassella between 1963 and 1966 . It no longer plays a therapeutic role today, since the effects cannot be used therapeutically or are even harmful.

Individual evidence

^ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer, 2014, ISBN 978-1-4757-2085-3 , pp. 269 ( limited preview in Google Book search).
↑ ^a ^b ^c ^d ^e ^f Entry on carbocromene. In: Römpp Online . Georg Thieme Verlag, accessed on August 16, 2017.
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ Electrocardiology of Cardiac Emergency . Springer-Verlag, 2013, ISBN 978-3-642-72339-1 , pp. 189 ( limited preview in Google Book search).
^ Pharmaceutical Manufacturing Encyclopedia . Elsevier, 2013, ISBN 978-0-8155-1856-3 , pp. 1012 ( limited preview in Google Book search).
↑ Process for producing solid preparations containing carbocromene hydrochloride. A process for producing solid preparations containing carbocromene hydrochloride. In: google.com. Retrieved August 16, 2017 .
↑ Drug Dosage in Renal Insufficiency . Springer Science & Business Media, 2012, ISBN 978-94-011-3804-8 , pp. 98 ( limited preview in Google Book search).
↑ Pharmacology and Toxicology . Springer-Verlag, 2013, ISBN 978-3-642-98030-5 , p. 754 ( limited preview in Google Book search).
↑ Pharmacognosy - Phytopharmacy . Springer-Verlag, 2009, ISBN 978-3-642-00963-1 , p. 1406 ( limited preview in Google Book Search).

[1] The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer, 2014, ISBN 978-1-4757-2085-3 , pp. 269 ( limited preview in Google Book search).

[RömppOnline-2] ↑ ^a ^b ^c ^d ^e ^f Entry on carbocromene. In: Römpp Online . Georg Thieme Verlag, accessed on August 16, 2017.

[NV-3] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[4] Electrocardiology of Cardiac Emergency . Springer-Verlag, 2013, ISBN 978-3-642-72339-1 , pp. 189 ( limited preview in Google Book search).

[5] Pharmaceutical Manufacturing Encyclopedia . Elsevier, 2013, ISBN 978-0-8155-1856-3 , pp. 1012 ( limited preview in Google Book search).

[6] Process for producing solid preparations containing carbocromene hydrochloride. A process for producing solid preparations containing carbocromene hydrochloride. In: google.com. Retrieved August 16, 2017 .

[7] Drug Dosage in Renal Insufficiency . Springer Science & Business Media, 2012, ISBN 978-94-011-3804-8 , pp. 98 ( limited preview in Google Book search).

[8] Pharmacology and Toxicology . Springer-Verlag, 2013, ISBN 978-3-642-98030-5 , p. 754 ( limited preview in Google Book search).

[9] Pharmacognosy - Phytopharmacy . Springer-Verlag, 2009, ISBN 978-3-642-00963-1 , p. 1406 ( limited preview in Google Book Search).