Christof von Kalle
Christof von Kalle (born March 6, 1962 in Hellersen ) is a German oncologist , university professor and head of the National Center for Tumor Diseases (NCT) in Heidelberg .
Career
Von Kalle studied medicine at the University of Cologne from 1981 to 1987 . He completed his internship at Albert Einstein Medical School , Memorial Sloan-Kettering Cancer Center and Cornell University Medical College . From 1988 to 1989 he was a PhD student with Volker Diehl in Cologne . In 1991, with his dissertation on the cross-sectional examination of microangiopathy-associated parameters in type I diabetic children, he was awarded a Dr. med. PhD . From 1990 to 1992 von Kalle worked at the German Cancer Research Center (DKFZ) in Heidelberg. He was a Research Associate at the Fred Hutchinson Cancer Research Center (FHCRC) in Seattle from 1992 to 1994 . From 1994 to 1995 he was a post-doctoral student with Volker Diehl in Cologne. In 1996 von Kalle moved to the Albert-Ludwigs-Universität Freiburg , where he worked as a doctor in Department I, and then as a group leader and Roland Mertelsmann , later with Christoph Peters . In 2003, Kalle completed his habilitation in Freiburg . In 2004 he received a C3 professorship at the University of Freiburg and worked in the field of applied stem cell biology and gene therapy . In 2005 he left Freiburg and went to Heidelberg. Since July 1, 2005, von Kalle has been managing director of the NCT and spokesman for the board of directors together with Dirk Jäger . Both are successors to Volker Diehl, who has been acting head of the center since January 1, 2004. In addition, von Kalle heads the Translational Oncology department as Director. At the DKFZ he heads the Translational Oncology department.
Von Kalle is married and has two sons.
Honors
In 2003 von Kalle received the Young Investigator Award from the American Society of Gene Therapy, in 2005 the Langen Science Award from the Paul Ehrlich Institute and in 2011 the Eva Luise Köhler Research Award for Rare Diseases.
Publications (selection)
- NB Woods, V. Bottero, M. Schmidt, C. von Kalle, IM Verma: Gene therapy: therapeutic gene causing lymphoma. In: Nature . Volume 440, Number 7088, April 2006, p. 1123, ISSN 1476-4687 . doi: 10.1038 / 4401123a . PMID 16641981 .
- A. Hajitou, M. Trepel, CE Lilley, S. Soghomonyan, MM Alauddin, FC Marini, BH Restel, MG Ozawa, CA Moya, R. Rangel, Y. Sun, K. Zaoui, M. Schmidt, C. von Kalle , MD Weitzman, JG Gelovani, R. Pasqualini, W. Arap: A hybrid vector for ligand-directed tumor targeting and molecular imaging. In: Cell . Volume 125, Number 2, April 2006, pp. 385-398, ISSN 0092-8674 . doi: 10.1016 / j.cell.2006.02.042 . PMID 16630824 .
- E. Montini, D. Cesana, M. Schmidt, F. Sanvito, M. Ponzoni, C. Bartholomae, L. Sergi Sergi, F. Benedicenti, A. Ambrosi, C. Di Serio, C. Doglioni, C. von Kalle , L. Naldini: Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. In: Nature biotechnology . Volume 24, Number 6, June 2006, pp. 687-696, ISSN 1087-0156 . doi: 10.1038 / nbt1216 . PMID 16732270 .
- A. Fischer, SH Abina, A. Thrasher, C. von Kalle, M. Cavazzana-Calvo: LMO2 and gene therapy for severe combined immunodeficiency. In: The New England journal of medicine . Volume 350, Number 24, June 2004, pp. 2526-2527, ISSN 1533-4406 . doi: 10.1056 / NEJM200406103502422 . PMID 15190153 .
- M. Schmidt, DA Carbonaro, C. Speckmann, M. Wissler, J. Bohnsack, M. Elder, BJ Aronow, JA Nolta, DB Kohn, C. von Kalle: Clonality analysis after retroviral-mediated gene transfer to CD34 + cells from the cord blood of ADA-deficient SCID neonates. In: Nature medicine . Volume 9, Number 4, April 2003, pp. 463-468, ISSN 1078-8956 . doi: 10.1038 / nm844 . PMID 12640448 .
- S. Hacein-Bey-Abina, C. von Kalle, M. Schmidt, F. Le Deist, N. Wulffraat, E. McIntyre, I. Radford, JL Villeval, CC Fraser, M. Cavazzana-Calvo, A. Fischer: A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. In: The New England Journal of Medicine . Volume 348, Number 3, January 2003, pp. 255-256, ISSN 1533-4406 . doi: 10.1056 / NEJM200301163480314 . PMID 12529469 .
Web links
- J. Müller-Jung: The genetic researcher Christof von Kalle: Artificial enzymes are the surgeons of the future. In: Frankfurter Allgemeine Zeitung of July 26, 2007
Individual evidence
- ↑ Resonator podcast of the Helmholtz Association : DKFZ researcher Christof von Kalle (episode 15, September 20, 2013)
- ↑ About Prof. Dr. Christof von Kalle. National Center for Tumor Diseases , archived from the original on July 10, 2014 ; Retrieved April 2, 2016 .
- ↑ dkfz.de: Translational Oncology Department. Retrieved June 23, 2012
- ↑ dkfz.de: Executive chair occupied by a successful haemato-oncologist. 18 July 2005
- ↑ dkfz.de: Excellent: Eva Luise Köhler Research Prize for the gene therapy of rare diseases. From March 1, 2011
personal data | |
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SURNAME | Kalle, Christof von |
BRIEF DESCRIPTION | German oncologist and university professor |
DATE OF BIRTH | March 6, 1962 |
PLACE OF BIRTH | Hellersen |