Deferoxamine

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Structural formula
Deferoxamine-2D-skeletal.png
General
Non-proprietary name Deferoxamine
other names
  • Desferrioxamine
  • N '- [5- (acetyl-hydroxy-amino) pentyl] - N - {5- [3- (5-aminopentyl-hydroxy-carbamoyl) propanoylamino] pentyl} - N -hydroxy-butanediamide
Molecular formula C 25 H 48 N 6 O 8
External identifiers / databases
CAS number
  • 70-51-9
  • 138-14-7 (deferoxamine mesilate )
PubChem 2973
DrugBank DB00746
Wikidata Q419618
Drug information
ATC code

V03 AC01

Drug class

Antidote

Mechanism of action

Chelating agents

properties
Molar mass 560.68 g · mol -1
Physical state

firmly

Melting point

140 ° C

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances

Deferoxamine mesilate

no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
Toxicological data
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Deferoxamine is a drug that is used as an antidote for iron poisoning due to its high affinity for trivalent iron ions and its chelating property . It is marketed by Novartis in Germany, Austria, Switzerland and the rest of the EU as deferoxamine mesilate under the name Desferal .

Pharmacological properties

Deferoxamine is a high molecular weight compound with three hydroxamic acid groups and has a high affinity for iron (III) ions. It binds the iron released during hemoglobin breakdown and causes its renal excretion. Iron deficiency symptoms do not occur with short-term use.

Clinical information

Application areas (indications)

Deferoxamine is used as a parenterally administered drug for iron overload, including hemochromatosis , sideroblastic anemia , secondary hemosiderosis after blood transfusions and acute iron poisoning.

The deferoxamine test is used to determine pathological iron deposits. At the same time, a pathological deferoxamine test (desferal test) can be an indication of the presence of aluminum-induced osteopathy (low turnover osteopathy).

Other Information

Deferoxamine occurs naturally as a reddish color in Actinobacterium Streptomyces pilosus .

Individual evidence

  1. ↑ a b c Entry on deferoxamine in the ChemIDplus database of the United States National Library of Medicine (NLM) .
  2. ↑ Deferoxamine mesylate salt data sheet from Sigma-Aldrich , accessed on May 9, 2017 ( PDF ).
  3. ↑ Red List online, as of September 2009.
  4. ↑ AM comp. d. Switzerland, as of September 2009.
  5. ↑ AGES-PharmMed, as of September 2009.

literature

  • Pschyrembel , 256th edition.
  • Aktories / Förstermann / Hofmann / Starke: General and special pharmacology and toxicology. 9th edition, Urban & Fischer, Munich / Jena 2005. ISBN 3-437-44490-5 .
  • Herold, Internal Medicine 2010, p. 619.