Estramustine

Structural formula
General
Non-proprietary name	Estramustine
other names	17 β -hydroxyestra-1,3,5 (10) -trien-3-yl- N , N -bis (2-chloroethyl) carbamate
Molecular formula	C 23 H 31 Cl 2 NO 3
External identifiers / databases
EC number	221-076-3
ECHA InfoCard	100.019.161
PubChem	259331
ChemSpider	227635
DrugBank	DB01196
Wikidata	Q412939
Drug information
ATC code	L01 XX11
Drug class	Cytostatic
properties
Molar mass	440.40 g · mol -1
Physical state	firmly
Melting point	104-105 ° C
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances danger
H and P phrases	H: 351-360
	P: ?
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Estramustine (trade name: Estracyt, among others, manufactured by Pharmacia , etc.) is a cytostatic agent , in the structurally combining an alkylating agent ( alkylating agents , nitrogen mustard derivative) and estrogen ( estradiol ) is present (dual mechanism of action).

pharmacology

application

It is used in the secondary treatment of advanced prostate cancer .

Side effects

As with other cytostatics, the side effects are mainly derived from the inhibitory effects on rapidly dividing body cells:

Trade names

Monopreparations

Cellmustin (D), EstraCept (D), Estracyt (D, A, CH), Medactin (D), Multosin (D) and a generic (D)

Individual evidence

^ The Merck Index . An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, pp. 635-636, ISBN 978-0-911910-00-1 .
↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of estramustine in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), retrieved on February 7, 2020, is reproduced from a self-classification by the distributor .
↑ Red List, as of August 2009.
↑ AM comp. d. Switzerland, as of August 2009.
↑ AGES-PharmMed, as of August 2009.

[MerckIndex-1] The Merck Index . An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, pp. 635-636, ISBN 978-0-911910-00-1 .

[2] Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of estramustine in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), retrieved on February 7, 2020, is reproduced from a self-classification by the distributor .

[RL-3] Red List, as of August 2009.

[AMK-4] AM comp. d. Switzerland, as of August 2009.

[AGES-5] AGES-PharmMed, as of August 2009.