Famciclovir

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Structural formula
Structural formula of famciclovir
General
Non-proprietary name Famciclovir
other names
  • 2- [2- (2-Amino-9 H -purin-9-yl) ethyl] -1,3-propanediyl diacetate
  • [2- (Acetyloxymethyl) -4- (2-aminopurin-9-yl) butyl] acetate ( IUPAC )
Molecular formula C 14 H 19 N 5 O 4
External identifiers / databases
CAS number 104227-87-4
EC number 630-411-6
ECHA InfoCard 100.158.713
PubChem 3324
ChemSpider 3207
DrugBank DB00426
Wikidata Q420186
Drug information
ATC code
Drug class

Antiviral

properties
Molar mass 321.33 g mol −1
Physical state

firmly

Melting point

102-104 ° C

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Famciclovir is an analogue of the nucleobase 2-aminopurine and is used as an antiviral agent for infections and reactivation of herpes simplex viruses (HSV-1 and -2) and varicella-zoster virus (VZV).

chemistry

Famciclovir is the di acetyl - derivative of penciclovir which, after oral sufficient ingestion bioavailability achieved. This made it necessary to develop a substance with better pharmacokinetics .

pharmacology

Famciclovir is a prodrug of penciclovir that is metabolized after oral ingestion and is converted to penciclovir by deacetylation and subsequent oxidation .

application

The active ingredient is used as a relapse for the treatment of genital herpes or for the early treatment of herpes zoster ("shingles"). In combination with lamivudine , famciclovir has also been used in studies to replace combination interferon therapy in chronic hepatitis B infection. This has become obsolete since the availability of specific antivirals against the hepatitis B virus.

Individual evidence

  1. ^ The Merck Index . An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, p. 670, ISBN 978-0-911910-00-1 .
  2. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  3. ↑ C. Trépo et al .: Famciclovir in chronic hepatitis B: results of a dose-finding study. Jornal of Hepatology (2000) 32 (6): pp. 1011-1018 PMID 10898322

Trade names

Monopreparations

Famvir (D, A, CH) and a generic (A)

Web links

  • Entry for famciclovir in the Human Metabolome Database (HMDB) , accessed October 29, 2013.