Famciclovir
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Non-proprietary name | Famciclovir | |||||||||||||||||||||
other names |
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Molecular formula | C 14 H 19 N 5 O 4 | |||||||||||||||||||||
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Drug information | ||||||||||||||||||||||
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Drug class |
Antiviral |
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properties | ||||||||||||||||||||||
Molar mass | 321.33 g mol −1 | |||||||||||||||||||||
Physical state |
firmly |
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Melting point |
102-104 ° C |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Famciclovir is an analogue of the nucleobase 2-aminopurine and is used as an antiviral agent for infections and reactivation of herpes simplex viruses (HSV-1 and -2) and varicella-zoster virus (VZV).
chemistry
Famciclovir is the di acetyl - derivative of penciclovir which, after oral sufficient ingestion bioavailability achieved. This made it necessary to develop a substance with better pharmacokinetics .
pharmacology
Famciclovir is a prodrug of penciclovir that is metabolized after oral ingestion and is converted to penciclovir by deacetylation and subsequent oxidation .
application
The active ingredient is used as a relapse for the treatment of genital herpes or for the early treatment of herpes zoster ("shingles"). In combination with lamivudine , famciclovir has also been used in studies to replace combination interferon therapy in chronic hepatitis B infection. This has become obsolete since the availability of specific antivirals against the hepatitis B virus.
Individual evidence
- ^ The Merck Index . An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, p. 670, ISBN 978-0-911910-00-1 .
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ C. Trépo et al .: Famciclovir in chronic hepatitis B: results of a dose-finding study. Jornal of Hepatology (2000) 32 (6): pp. 1011-1018 PMID 10898322
Trade names
Famvir (D, A, CH) and a generic (A)
Web links
- Entry for famciclovir in the Human Metabolome Database (HMDB) , accessed October 29, 2013.