Florasulam

Structural formula
General
Surname	Florasulam
other names	N - (2,6-Difluorophenyl) -8-fluoro-5-methoxy [1,2,4] triazolo [1,5- c ] pyrimidine-2-sulfonamide
Molecular formula	C 12 H 8 F 3 N 5 O 3 S
External identifiers / databases
CAS number 145701-23-1 EC number 604-488-1 ECHA InfoCard 100.127.229 PubChem 11700495 ChemSpider 9875220 Wikidata Q22807578
properties
Molar mass	359.29 g mol −1
Physical state	firmly
Melting point	193.5–230.5 ° C (with decay)
solubility	poorly soluble in water (6.26 g l −1 at 20 ° C)
safety instructions
GHS hazard labeling from  Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary Caution H and P phrases H: 410 P: 273
Toxicological data	> 5000 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Florasulam is an active ingredient in crop protection and belongs to the class of herbicides . It is a white solid.

history

Florasulam was developed by Dow AgroSciences and introduced around 2000.

effect

Florasulam is a selective, systemic herbicide . It is picked up via the leaves and transported on. The active ingredient acts as an ALS inhibitor . Here, the biosynthesis of amino acids L leucine , L -isoleucine and L -valine , so some essential amino acids , inhibited . This inhibits cell division , so that growth comes to a standstill. Ultimately, the plants fade and necrosis forms , which is why the weeds die.

use

It is mainly used against broad-leaved weeds in cereal and maize crops.

Environmental aspects

Florasulam is not toxic to bees, but it is chronically hazardous to water . The degradation takes place microbially . The methoxy group is demethylated first . The heterocyclic ring system is then cleaved . This happens with a half-life of 2 to 18 days.

proof

In plants and soils, residues can be determined after derivatization using the GC method or HPLC method .

Admission status

In Germany and in the EU does not have so far pesticides admitted that this active ingredient contained.

Individual evidence

1. ↑ ^{a b c d e f g h i} Entry on Florasulam. In: Römpp Online . Georg Thieme Verlag, accessed on July 14, 2020.
2. ↑ ^{a b c} Datasheet Florasulam at Sigma-Aldrich , accessed on July 14, 2020 ( PDF ).
3. ↑ Entry on Florasulam in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on July 17, 2020. Manufacturers or distributors can expand the harmonized classification and labeling .