Fluenetil

Structural formula
General
Surname	Fluenetil
other names	2-fluoroethyl-4-biphenyl acetate; Lambrol;
Molecular formula	C 16 H 15 FO 2
Brief description	colorless, crystalline solid
External identifiers / databases
ECHA InfoCard	100.149.202
PubChem	20288
ChemSpider	19113
Wikidata	Q5462651
properties
Molar mass	258.29 g mol −1
Physical state	firmly
density	1.139 g cm −3 (68 ° C)
Melting point	60.5 ° C
boiling point	177–180 ° C (1.3 mbar)
solubility	practically insoluble in water: 2.5 mg l −1 (25 ° C); Easily soluble in acetone (> 850 g l −1 ), acetonitrile , benzene , ethanol ;
safety instructions
GHS hazard labeling from Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary danger
H and P phrases	H: 310-300
	P: 262-280-301 + 310-321-405-501
Toxicological data	6 mg kg −1 ( LD 50 , rat , oral ) ; 0.884 mg l −1 ( LC 50 , fish , 96 h ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Fluenetil is a chemical compound from the group of biphenyls , which was introduced by Montedison in 1965 as an acaricide .

The now obsolete acaricide was used to control eggs from mites. The area of application was, for example, grain cultivation. It is not approved as a crop protection agent in the European Union or Switzerland .

Fluenetil is metabolized into fluorocitric acid, which inhibits the enzyme aconitase . This leads to the death of the organism via an accumulation of citrate.

Individual evidence

↑ ^a ^b Entry on Flufenetil in the Pesticide Properties DataBase (PPDB) of the University of Hertfordshire , accessed on August 2, 2019.
↑ ^a ^b ^c ^d ^e ^f Entry on Fluenetil in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .
↑ ^a ^b ^c The Pesticide Manual, Volume 16 ( Memento of July 14, 2014 in the Internet Archive ) p. 276.
↑ Entry on 2-fluoroethyl biphenyl-4-ylacetate in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ Safety data sheet according to 1907/2006 / EC, Article 31 - Fluenetil. (PDF) LGC Standards, April 12, 2019, accessed August 2, 2019 .
↑ Patent US3436418 : Fluorinated aromatic esters. Registered on December 8, 1964 , published April 1, 1969 , applicant: Montedison, inventor: Alberto Barontini, Giorgio Rossi, Pietro De Pietri Tonelli. ‌
^ Directorate-General for Health and Food Safety of the European Commission: EU pesticide database ; Entry in the national directory of plant protection products in Switzerland ; Retrieved June 25, 2016.
^ Frederick R. Johannsen, Charles O. Knowles: Toxicity and action of fluenethyl acaricide and related compounds in the mouse, housefly and twospotted spider mite . In: Comparative and General Pharmacology . tape 5 , no. 1 , January 1974, p. 101–110 , doi : 10.1016 / s0306-3623 (74) 80014-5 ( PDF ).

[PPDB-1] Entry on Flufenetil in the Pesticide Properties DataBase (PPDB) of the University of Hertfordshire , accessed on August 2, 2019.

[GESTIS-2] ↑ ^a ^b ^c ^d ^e ^f Entry on Fluenetil in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .

[pm16-3] The Pesticide Manual, Volume 16 ( Memento of July 14, 2014 in the Internet Archive ) p. 276.

[CLP_100.149.202-4] Entry on 2-fluoroethyl biphenyl-4-ylacetate in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[5] Safety data sheet according to 1907/2006 / EC, Article 31 - Fluenetil. (PDF) LGC Standards, April 12, 2019, accessed August 2, 2019 .

[6] Patent US3436418 : Fluorinated aromatic esters. Registered on December 8, 1964 , published April 1, 1969 , applicant: Montedison, inventor: Alberto Barontini, Giorgio Rossi, Pietro De Pietri Tonelli. ‌

[7] Directorate-General for Health and Food Safety of the European Commission: EU pesticide database ; Entry in the national directory of plant protection products in Switzerland ; Retrieved June 25, 2016.

[8] Frederick R. Johannsen, Charles O. Knowles: Toxicity and action of fluenethyl acaricide and related compounds in the mouse, housefly and twospotted spider mite . In: Comparative and General Pharmacology . tape 5 , no. 1 , January 1974, p. 101–110 , doi : 10.1016 / s0306-3623 (74) 80014-5 ( PDF ).