Furan-2-carboxylic acid chloride
Structural formula | ||||||||||||||||
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General | ||||||||||||||||
Surname | Furan-2-carboxylic acid chloride | |||||||||||||||
other names |
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Molecular formula | C 5 H 3 ClO 2 | |||||||||||||||
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properties | ||||||||||||||||
Molar mass | 130.53 g mol −1 | |||||||||||||||
Physical state |
liquid |
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Melting point |
-1 ° C |
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boiling point |
173 ° C |
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safety instructions | ||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Furan-2-carboxylic acid chloride is a chemical compound from the group of furans and carboxylic acid chlorides .
Extraction and presentation
Furan-2-carboxylic acid chloride can be prepared by reacting furan-2-carboxylic acid with phosphorus pentachloride or thionyl chloride .
use
Furan-2-carboxylic acid chloride is required for the synthesis of furalaxyl and the drugs mometasone furoate and diloxanide furoate .
The compound reacts with phenols and AlCl 3 in a Friedel-Crafts reaction to form hydroxyphenyl furyl ketones.
Individual evidence
- ↑ a b David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 90th edition. (Internet version: 2010), CRC Press / Taylor and Francis, Boca Raton, FL, Physical Constants of Organic Compounds, pp. 3-264.
- ↑ a b Data sheet 2-Furoyl chloride, 95% from Sigma-Aldrich , accessed on January 4, 2015 ( PDF ).
- ^ WW Hartman, JB Dickey: Furoyl Chloride . In: Industrial & Engineering Chemistry . tape 24 , no. 2 , February 1932, p. 151-152 , doi : 10.1021 / ie50266a008 .
- ^ Henry Gilman , Joseph B. Dickey: The Friedel-Crafts reaction with phenols and furoyl chloride . In: Recueil des Travaux Chimiques des Pays-Bas . tape 52 , no. 5 , 1933, pp. 389-394 , doi : 10.1002 / recl.19330520506 .