Georg Nickenig

from Wikipedia, the free encyclopedia

Georg Nickenig (born April 11, 1964 in Mülheim-Kärlich ) is a German cardiologist and since 2005 Professor and Director of the Medical Clinic and Polyclinic II of the Bonn University Hospital and director of the Bonn Heart Center .

Life

Nickenig completed his Abitur in 1983 at the Görres-Gymnasium in Koblenz and studied human medicine at the Rheinische Friedrich-Wilhelms-Universität Bonn from 1983 to 1989 . He then spent two years as an intern at the Clinic for Cardiovascular Surgery and the Medical Polyclinic of the University of Bonn. In 1991 he was in Bonn with an investigation for immunosuppression in the cytostatic therapy to Dr. med. PhD . From 1991 to 1995 Nickenig was an assistant doctor and research assistant at the Medical University Polyclinic in Bonn. During this time, he conducted research in 1993 and 1994 as part of a research grant from the German Research Foundation at the Emory University School of Medicine (Department of Cardiology / Pharmacology) in Atlanta , USA.

From 1996 to 2000 Nickenig was a research assistant at Clinic III for Internal Medicine at the University of Cologne . During this time Nickenig became a specialist in internal medicine (1998) and later a specialist in cardiology (2000). In 2000 he completed his habilitation in internal medicine / cardiology at the University of Cologne. In 2000, Nickenig became the managing senior physician at the Clinic and Polyclinic for Internal Medicine III (cardiology) and private lecturer at the Saarland University Hospital in Homburg , where he received an unscheduled professorship in 2004 .

In October 2005 Nickenig received a call to the Department of Internal Medicine (Cardiology, Angiology , Pneumology and Intensive Care Medicine) at the University of Bonn and was - Berndt Lüderitz below - director of the Department of Internal Medicine II at the University Hospital Bonn.

Together with the cardiac surgeon Hendrik Treede, Nickenig heads the heart center of the University Hospital Bonn , founded the International Center for Cardiovascular Interventions (ICCI) in 2011 and has been the spokesman for the "Transregional Collaborative Research Center 259 - Aortic Diseases" of the German Research Foundation since July 2019. He is also the scientific director of the Cardiosymposium Bonn.

Nickenig is married and has two children. He lives with his family in the Plittersdorf district of Bonn. He is a member of the AV Tuisconia Königsberg zu Bonn in the Cartell Association (CV) .

Research priorities

Georg Nickenig's medical work focuses on coronary heart disease, heart failure , arterial hypertension and hypercholesterolemia . The main research interests are the causes of atherosclerosis and myocardial infarction .

In his experimental, clinical and scientific work he was able to show the central role of angiotensin II, AT1 receptor and oxidative stress in the development of endothelial dysfunction and atherosclerosis in various cell culture and animal experimental models and clinical studies.

Since 2015, Nickenig and his working groups have also been researching the fundamentals of aortic valve and aortic wall diseases such as B. aortic stenosis, aortic aneurysms and aortic dissection. In this area, Nickenig was able to prove that inflammatory processes are of great importance for the development of these diseases. In 2019 the special research area “Transregio 259 - Aortic Diseases” was approved, for which Nickenig acts as spokesman. The volume is 13 million euros in the first four years.

In the field of clinical research, Nickenig is considered a pioneer in the minimally invasive interventional treatment of heart valve defects such as B. Aortic valve stenosis treated by a transaortic valve replacement procedure (TAVI). Together with his research team, he is also a leader in the catheter-based treatment of mitral valve and tricuspid valve defects and in 2019 presented the world's largest study on this topic.

Nickenig's interventional interventions are regularly broadcast as live cases at international congresses.

In 2012, Nickenig implanted the former Foreign Minister Hans-Dietrich Genscher with a new heart valve using a catheter-assisted procedure .

His scientific work is documented in more than 600 international publications.

Awards

  • 1996 Oskar Lapp Prize from the German Society for Cardiology
  • 1996 H. and G. Meise Prize of the German Society for Rehabilitation and Preventive Medicine
  • 1996 German Heart Aid Prevention Award
  • 1997 Dieter Klaus Prize for Hypertension Research from the German Hypertension League
  • 1997 Research Award from the German Heart Foundation
  • 1999 Young Investigator Award from the European Vascular Biology Society
  • 1999 Irbesartan Research Award
  • 2001 Novartis Prize for Therapy-Relevant Pharmacological Research
  • 2001 Calogero Pagliarello Research Prize
  • 2001 Theodor Frerichs Prize of the German Society for Internal Medicine
  • 2004 Albert Fraenkel Prize of the German Society for Cardiology
  • 2018 Franz Loogen Prize of the West German Heart and Vascular Center Essen and the Franz Loogen Foundation

Fonts (selection)

  • with Sachinidis A, Michaelsen F, Böhm M, Seewald S, Vetter H. Upregulation of vascular angiotensin II receptor gene expression by low density lipoprotein in vascular smooth muscle cells. Circulation 1997; 95: 473-478
  • with Baudler S, Müller C, Werner C, Werner N, Welzel H, Strehlow K, Böhm M. Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo. FASEB J 2002; 16: 1077-1086
  • with Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, Hirsch-Hoffmann B, Schwoerer AP, Lau D, Fu X, Klingel K, Sydow K, Didié M, Seniuk A, von Leitner EC, Szoecs K, Schrickel JW, Treede H, Wenzel U, Lewalter T, Zimmermann WH, Meinertz T, Böger RH, Reichenspurner H, Freeman BA, Eschenhagen T, Ehmke H, Hazen SL, Willems S, Baldus S. Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation . Nat Med. 2010; 16 (4): 470-4. Epub 2010 Mar 21.
  • with Sinning JM, Losch J, Walenta K, Böhm M, Werner N. Circulating CD31 + / Annexin V + microparticles correlate with cardiovascular outcomes. Eur Heart J. 2011; 32 (16) 2034-41
  • with Jansen F, Yang X, Baumann K, Przybilla D, Schmitz T, Flender A, Paul K, Alhusseiny A, Werner N. Endothelial microparticles reduce ICAM-1 expression in a microRNA-222-dependent mechanism. J Cell Mol Med. 2015 Sep; 19 (9): 2202-14.
  • mit Steinmetz M, Lucanus E, Zimmer S, Werner N. Mobilization of sca1 / flk-1 positive endothelial progenitor cells declines in apolipoprotein E-deficient mice with a high-fat diet. J Cardiol. 2015 Mar 24. pii: S0914-5087 (15) 00058-1. [Epub ahead of print]
  • with Jansen F, Stumpf T, Proebsting S, Franklin BS, Wenzel D, Pfeifer P, Flender A, Schmitz T, Yang X, Fleischmann BK, Werner N. Intercellular transfer of miR-126-3p by endothelial microparticles reduces vascular smooth muscle cell proliferation and limits neointima formation by inhibiting LRP6. J Mol Cell Cardiol. 2017 Mar; 104: 43-52
  • with Strehlow K, Wassmann S, Bäumer AT, Ahlbory K, Sauer H, Böhm M. Differential effects of estrogen and progesterone on AT1 receptor gene expression in vascular smooth muscle cells. Circulation 2000; 102: 1828-1833
  • with Wassmann S, Bäumer AT, Strehlow K, van Eickels M, Grohé C, Ahlbory K, Rösen R, Böhm M. Endothelial dysfunction and oxidative stress during estrogen deficiency in spontaneously hypertensive rats. Circulation 2001; 103: 435-441
  • mit Schueler R, Momcilovic D, Weber M, Welz A, Werner N, Mueller C, Ghanem A, Hammerstingl C. Acute changes of mitral valve geometry during interventional edge-to-edge repair with the MitraClip system are associated with midterm outcomes in patients with functional valve disease: preliminary results from a prospective single-center study. Circ Cardiovasc Interv. 2014 Jun; 7 (3): 390-9.
  • with Maisano F, Taramasso M, Hammerstingl C, Vahanian A, Messika-Zeitoun D, ​​Baldus S, Huntgeburth M, Alfieri O, Colombo A, La Canna G, Agricola E, Zuber M, Tanner FC, Topilsky Y, Kreidel F, Kuck KH. Cardioband, a transcatheter surgical-like direct mitral valve annuloplasty system: early results of the feasibility trial. Eur Heart J. 2016 Mar 7; 37 (10): 817-25.
  • with Schueler R, Dager A, Martinez Clark P, Abizaid A, Siminiak T, Buszman P, Demkow M, Ebner A, Asch FM, Hammerstingl C. Treatment of Chronic Functional Mitral Valve Regurgitation With a Percutaneous Annuloplasty System. J Am Coll Cardiol. 2016 Jun 28; 67 (25): 2927-36.
  • with Hammerstingl C, Schueler R, Topilsky Y, Grayburn PA, Vahanian A, Messika-Zeitoun D, ​​Urena Alcazar M, Baldus S, Volker R, Huntgeburth M, Alfieri O, Latib A, La Canna G, Agricola E, Colombo A, Kuck KH, Kreidel F, Frerker C, Tanner FC, Ben-Yehuda O, Maisano F. Transcatheter Mitral Annuloplasty in Chronic Functional Mitral Regurgitation: 6-Month Results With the Cardioband Percutaneous Mitral Repair System. JACC Cardiovasc Interv. 2016 Oct 10; 9 (19): 2039-2047
  • with Kowalski M, House Manager J, Braun D, ​​Schofer J, Yzeiraj E, Rudolph V, Friedrichs K, Maisano F, Taramasso M, Fam NP, Bianchi G, Bedogni F, Denti P, Alfieri O, Latib A, Colombo A, Hammerstingl C, Schueler R. Transcatheter Treatment of Severe Tricuspid Regurgitation with the Edge-to-Edge: MitraClip Technique. Circulation. 2017 May 9; 135 (19): 1802-1814
  • with Weber M, Schueler R, House Manager J, Näbauer M, von Bardeleben RS, Sotiriou E, Schäfer U, Deuschl F, Kuck KH, Kreidel F, Juliard JM, Brochet E, Latib A, Agricola E, Baldus S, Friedrichs K, Vandrangi P, Verta P, Hahn RT, Maisano F. 6-Month Outcomes of Tricuspid Valve Reconstruction for Patients With Severe Tricuspid Regurgitation. J Am Coll Cardiol. 2019 Apr 23; 73 (15): 1905-1915. doi: 10.1016 / j.jacc.2019.01.062.
  • with Weber M, Lurz P, von Bardeleben RS, Sitges M, Sorajja P, Hausleiter J, Denti P, Trochu JN, Näbauer M, Dahou A, Hahn RT Transcatheter edge-to-edge repair for reduction of tricuspid regurgitation: 6- month outcomes of the TRILUMINATE single-arm study.Lancet. 2019 Nov 30; 394 (10213): 2002-2011.

Web links

Individual evidence

  1. ↑ Nickenig's curriculum vitae. Retrieved March 24, 2020 .
  2. ↑ Georg Nickenig's curriculum vitae. Retrieved March 20, 2020 .
  3. ↑ Professor Nickenig now heads the University of Cardiology - University of Bonn. Retrieved March 24, 2020 .
  4. ^ WDR: WDR report on the heart center Bonn. Retrieved March 23, 2020 .
  5. ↑ A heart specialist for small incisions with a big impact - University of Bonn. Retrieved March 24, 2020 .
  6. ^ Change at the top of the cardiology department at the Brothers Hospital / Brothers Hospital Trier. Retrieved March 24, 2020 .
  7. ↑ TRR 259 - University of Bonn. Retrieved March 24, 2020 .
  8. ↑ Scientific management - Cardio Symposium Bonn. Retrieved on March 24, 2020 (German).
  9. ↑ Professor Nickenig now heads the University of Cardiology - University of Bonn. Retrieved March 24, 2020 .
  10. ^ DFG - German Research Foundation - 14 new Collaborative Research Centers. Retrieved March 24, 2020 .
  11. ^ Margit Warken-Dieke: Research in Bonn: University Clinic conducts cutting-edge research on aortic diseases. Retrieved March 24, 2020 .
  12. ^ GA BONN: University Hospital Bonn: Professor Georg Nickenig uses a mini heart valve for the first time. Retrieved March 24, 2020 .
  13. ↑ Medicine: Attack on the Heart - DER SPIEGEL 50/2014. Retrieved March 24, 2020 .
  14. ↑ Georg Nickenig, Marcel Weber, Philipp Lurz, Ralph Stephan von Bardeleben, Marta Sitges: Transcatheter edge-to-edge repair for reduction of tricuspid regurgitation: 6-month outcomes of the TRILUMINATE single-arm study . In: The Lancet . tape 394 , no. 10213 , November 30, 2019, ISSN  0140-6736 , p. 2002–2011 , doi : 10.1016 / S0140-6736 (19) 32600-5 , PMID 31708188 ( thelancet.com [accessed March 24, 2020]).
  15. ↑ Triluminate study Nickenig. Retrieved March 20, 2020 .
  16. ↑ Interview with Georg Nickenig Triluminate Study. Retrieved March 21, 2020 .
  17. ↑ Nicolas Ottersbach: Experts in demand around the world: University Hospital Bonn broadcasts heart surgery in a live stream. Retrieved March 24, 2020 .
  18. ↑ ALEXANDER KUFFNER: Transfer to the USA: 1200 doctors see super surgery from Bonn. October 25, 2013, accessed on March 24, 2020 (German).
  19. ↑ GA BONN: Ex-Foreign Minister: After a heart operation: "Genscher is doing very well". Retrieved March 24, 2020 .
  20. ↑ pubmeddev: nodding g - PubMed - NCBI. Retrieved March 24, 2020 .
  21. ↑ medicine. Retrieved March 24, 2020 .
  22. ↑ medicine. Retrieved March 24, 2020 .
  23. ↑ medicine. Retrieved March 24, 2020 .
  24. ↑ Prize winners. September 28, 2007, accessed March 24, 2020 .
  25. ↑ medicine. Retrieved March 24, 2020 .
  26. ↑ medicine. Retrieved March 24, 2020 .
  27. ↑ medicine. Retrieved March 24, 2020 .
  28. ↑ Article Deutsches Ärzteblatt. Retrieved March 24, 2020 .
  29. ↑ Saarland University - Annual Report 2001. July 16, 2007, accessed on March 24, 2020 .
  30. ↑ Research award for Homburg cardiologists: Dr. med. Georg Nickenig received the Albert Fraenkel Prize / Science, Research, Development, Economy, University, Institute, College, News. September 27, 2007, accessed March 24, 2020 .
  31. ↑ Research award for Homburg cardiologists: Dr. med. Georg Nickenig received the Albert Fraenkel Prize. Retrieved March 24, 2020 .
  32. ↑ Franz Loogen Prize | Serve. Retrieved March 24, 2020 .
personal data
SURNAME Nodding, Georg
BRIEF DESCRIPTION German cardiologist
DATE OF BIRTH April 11, 1964
PLACE OF BIRTH Mülheim-Kärlich