Lutz Hein

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Lutz Hein (born May 12, 1963 in Lübeck ) is a German doctor and pharmacologist and holder of Chair II at the Institute for Experimental and Clinical Pharmacology and Toxicology at the Albert Ludwig University of Freiburg .

The focus of his research is the pharmacology of cardiovascular diseases. Using transgenic animal models, Hein investigates the role of the sympathetic nervous system , the function of G-protein-coupled receptors and their signal transduction . In addition, he is interested in epigenetic modifications in the context of heart failure.

Life

Lutz Hein's interest in research was documented early on. In 1980 he won the “ Jugend forscht ” national prize in the field of biology. In 1979 and 1981 he won an award in the final round of the European Philips Contest for Young Scientists and Inventors .

In 1982 Hein began studying medicine in Kiel . He wrote his dissertation with the title “Lipidosis-like and Mucopolysaccharidosis-like cell changes in rats after treatment with tiloron analogues” at the anatomical institute under the supervision of Renate Lüllmann-Rauch . In 1988 he was promoted to Dr. med. PhD and then research assistant with Heinz Lüllmann at the pharmacological institute of the University of Kiel. From 1991 to 1996 he worked with Brian Kobilka , who was awarded the Nobel Prize in Chemistry in 2012, at Stanford University , where he laid the foundation for his research. In 1996 he switched to Martin Lohse at the Institute for Pharmacology and Toxicology at the University of Würzburg , where he completed his habilitation in 1999 (“Transgenic Models for Investigating the Function of G-Protein-Coupled Receptors”). In the same year he acquired the title of specialist in pharmacology and toxicology, and in 2003 he also became a specialist in clinical pharmacology. In 2004, Hein was appointed to chair II of the Institute for Experimental and Clinical Pharmacology and Toxicology at the University of Freiburg as the successor to Klaus Starke .

Hein is active in numerous scientific committees. He is a member of the drug commission of the German medical profession (since 2007), board member of the German Society for Pharmacology (2010), scientific advisory board of the German Foundation for Heart Research and chairman of the Freiburg Medical Society. In 2011 he was elected to the German Research Foundation's Medical Review Board. In 2012 he was elected a member of the Leopoldina .

plant

Lutz Hein is interested in G-protein-coupled receptors such as the presynaptic α2A, α2B or α2C autoreceptors at an axon terminal with noradrenaline.

Lutz Hein's work is an essential part of today's understanding of the role of G protein-coupled receptors in the cardiovascular system. He made a significant contribution, the function of the angiotensin AT 2 receptor and the various α 2 - adrenoceptors elucidated. Hein and his colleagues were able to demonstrate that α 2A and 2C adrenoceptors are part of a negative feedback mechanism that can prevent the development of heart failure. With the help of transgenic animal models, he was able to show that α 2C receptors are crucial for controlling the sympathetic nervous system in heart failure, while α 2A receptors contribute to this in healthy animals, but lose their function in the course of the disease.

It was surprising that α 2B receptors also play an important role in organ development, including in the placenta and lungs .

Lutz Hein summarized his experience with transgenic organisms in the Handbook of Experimental Pharmacology . Together with others, he publishes the textbook “Pharmacology and Toxicology” and the “Pocket Atlas of Pharmacology” for students.

Individual evidence

  1. ↑ a b c Klaus Starke: The history of the pharmacological institute of the University of Freiburg. 2nd Edition. 2007 (PDF)
  2. ↑ Homepage of the Institute for Experimental and Clinical Pharmacology and Toxicology at the University of Freiburg , accessed on December 31, 2010.
  3. ↑ Research focus of Lutz Hein at the Institute for Experimental and Clinical Pharmacology and Toxicology at the University of Freiburg , accessed on December 31, 2010.
  4. ↑ Jugend forscht : project presentation , accessed on December 26, 2012.
  5. ↑ a b Curriculum vitae of Lutz Hein ( memento from September 28, 2013 in the Internet Archive ) (PDF; 11 kB) at the BIOSS Center for biological signaling studies at the University of Freiburg , accessed on December 31, 2010.
  6. ↑ Lutz Hein: Lipidosis-like and mucopolysaccharidosis-like cell changes in rats after treatment with tiloron analogs. Dissertation ( Memento of the original from February 28, 2016 in the Internet Archive ) Info: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. . 1988. @1@ 2Template: Webachiv / IABot / kiopc4.ub.uni-kiel.de
  7. ↑ Lutz Hein: Transgenic models for the investigation of the function of G-protein-coupled receptors. Habilitation thesis . 1999.
  8. ↑ Presentation of Lutz Hein in the Pharmazeutische Zeitung (online), accessed on December 31, 2010.
  9. ↑ Lutz Hein at the Drugs Commission of the German Medical Association , accessed on December 31, 2010.
  10. ↑ Board of the German Society for Pharmacology , accessed on December 31, 2010.
  11. ^ German Foundation for Heart Research : Scientific Advisory Board , accessed on December 18, 2011.
  12. ↑ Freiburg Medical Society ( Memento of the original from May 19, 2011 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. , accessed February 3, 2011. @1@ 2Template: Webachiv / IABot / www.uniklinik-freiburg.de
  13. ↑ Results of the DFG Review Board Election 2011 (PDF; 246 kB), accessed on December 18, 2011.
  14. ↑ Member entry by Prof. Dr. Lutz Hein (with picture and CV) at the German Academy of Sciences Leopoldina , accessed on July 12, 2016.
  15. ↑ L. Hein, GS Barsh, RE Pratt, VJ Dzau , BK Kobilka: Behavioral and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. In: Nature . 377 (6551), 1995, pp. 744-747. PMID 7477266
  16. ^ L. Hein, JD Altman, BK Kobilka: Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. In: Nature. 402 (6758), 1999, pp. 181-184. PMID 10647009
  17. ↑ M. Brede, F. Wiesmann, R. Jahns, K. Hadamek, C. Arnolt, S. Neubauer, MJ Lohse, L. Hein: Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure. In: Circulation . 106 (19), 2002, pp. 2491-2496. PMID 12417548
  18. ^ R. Gilsbach, M. Brede, N. Beetz, E. Moura, V. Muthig, C. Gerstner, F. Barreto, S. Neubauer, MA Vieira-Coelho, L. Hein: Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction. In: Cardiovasc Res . 75 (4), 2007, pp. 728-737. PMID 17597596
  19. ^ R. Gilsbach, J. Schneider, A. Lother, S. Schickinger, J. Leemhuis, L. Hein: Sympathetic alpha (2) -adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload. In: Cardiovasc Res. 86 (3), 2010, pp. 432-442. PMID 20083574
  20. ↑ M. Philipp, ME Brede, K. Hadamek, M. Gessler, MJ Lohse, L. Hein: Placental alpha (2) -adrenoceptors control vascular development at the interface between mother and embryo. In: Nat Genet . 31 (3), 2002, pp. 311-315. PMID 12068299
  21. ^ V. Muthig, R. Gilsbach, M. Haubold, M. Philipp, T. Ivacevic, M. Gessler, L. Hein: Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice. In: Circ Res . 101 (7), 2007, pp. 682-691. PMID 17673674
  22. ↑ M. Haubold, R. Gilsbach, L. Hein: {Alpha} 2B-adrenoceptor deficiency leads to postnatal respiratory failure in mice. In: J Biol Chem . 285 (44), 2010, pp. 34213-34219. PMID 20729197
  23. ^ S. Offermanns, L. Hein (Ed.): Transgenic Models in Pharmacology. In: Handbook of Experimental Pharmacology. 159th edition. Springer, Berlin 2004.
  24. ↑ Heinz Lüllmann, Klaus Mohr, Lutz Hein: Pharmacology and Toxicology. 17th edition. Georg Thieme Verlag, Stuttgart 2010, ISBN 978-3-13-368517-7 .
  25. ↑ Heinz Lüllmann, Klaus Mohr, Lutz Hein: Pocket Atlas of Pharmacology. 6th edition. Georg Thieme Verlag, Stuttgart 2008, ISBN 978-3-13-707706-0 .
personal data
SURNAME Hein, Lutz
BRIEF DESCRIPTION German physician and pharmacologist
DATE OF BIRTH May 12, 1963
PLACE OF BIRTH Lübeck