Martha L. Ludwig

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Martha L. Ludwig (born August 16, 1931 in Pittsburgh , † November 27, 2006 in Ann Arbor , Michigan ) was an American biochemist and crystallographer . She worked for almost 40 years at the University of Michigan , where she mainly dealt with the crystal structure analysis of enzymes .

Life

Martha L. Ludwig was born as the daughter of Leon Ludwig and Agnes Sutermeister Ludwig, descendant of Arnold Sutermeister , on August 16, 1931 in Pittsburgh, Pennsylvania . Her father was a physicist and worked for Westinghouse Electric . The family moved to Buffalo when their father became a director of the local branch. Martha L. Ludwig studied chemistry at Cornell University until 1952 and received her master's degree in biochemistry from the University of California . She then received her PhD in 1956 on the biosynthesis of ergothioneine at the Biochemistry Faculty of Cornell University Medical College , which was then headed by Vincent du Vigneaud .

As a post-doctoral student she was then at the Massachusetts Institute of Technology and from 1962 at Harvard University in the laboratory of William Lipscomb , where she began to work on the X-ray structure analysis of enzymes, which has since become her main research area. Over the next five years, she was involved here on the structure elucidation of carboxypeptidase A . From 1967 she worked at the Department of Biological Chemistry at the University of Michigan Medical School, where she researched until her death in 2006. The focus was on the structure and function of flavodoxin , superoxide dismutase , methionine synthase and p-hydroxybenzoate hydroxylase as well as (in collaboration with Rowena Green Matthews ) methylene tetrahydrofolate reductase . Martha L. Ludwig also held the title of J. Lawrence Oncley Distinguished University Professor of Biological Chemistry and was Chair of the Biophysics Research Division on several occasions .

Martha L. Ludwig had been married to the Austrian physician Frederick Hoch since 1961 , who was professor of internal medicine at the University of Michigan Medical School and, like his wife, professor of biochemistry; he died in 2012.

Awards (selection)

Publications (selection)

literature

Individual evidence

  1. ^ Rowena Green Matthews: Martha L. Ludwig 1931-2006: A Biographical Memoir. National Academy of Sciences, Washington, DC 2011, p. 3 f.
  2. ^ Rowena Green Matthews: Martha L. Ludwig 1931-2006: A Biographical Memoir. National Academy of Sciences, Washington, DC 2011, p. 5.
  3. ^ Rowena Green Matthews: Martha L. Ludwig 1931-2006: A Biographical Memoir. National Academy of Sciences, Washington, DC 2011, pp. 6-14.
  4. ^ Sally J. Churchill: Report of Faculty Death. Regents of the University of Michigan. Retrieved July 17, 2014.
  5. ↑ Frederick L. High This. ( Memento from July 20, 2014 in the web archive archive.today ) Department of Biological Chemistry, University of Michigan Medical School 2012. Retrieved July 17, 2014.
  6. ↑ Francis P. Garvan-John M. Olin Medal. American Chemical Society (ACS). Retrieved July 17, 2014.
  7. ^ Martha L. Ludwig, University of Michigan. National Academy of Sciences, Deceased Members. Retrieved July 17, 2014.
personal data
SURNAME Ludwig, Martha L.
BRIEF DESCRIPTION American biochemist and crystallographer
DATE OF BIRTH August 16, 1931
PLACE OF BIRTH Pittsburgh
DATE OF DEATH November 27, 2006
Place of death Ann Arbor , Michigan