N -methyl- D -glucamine

Structural formula
Structural formula in the Fischer projection
General
Surname	N -methyl- D -glucamine
other names	Meglumine Methylglucamine 1-deoxy-1-methylamino sorbitol NMDG NMG D - (-) - N -methylglucamine METHYLGLUCAMINE ( INCI )
Molecular formula	C 7 H 17 NO 5
Brief description	white, odorless solid
External identifiers / databases
CAS number 6284-40-8 EC number 228-506-9 ECHA InfoCard 100.025.916 PubChem 8567 ChemSpider 8249 Wikidata Q288875
properties
Molar mass	195.22 g mol −1
Physical state	firmly
Melting point	128-131 ° C
boiling point	210 ° C (decomposition)
solubility	easily soluble in water: 1000 g l −1 (25 ° C)
safety instructions
GHS labeling of hazardous substances no GHS pictograms H and P phrases H: no H-phrases P: no P-phrases
Toxicological data	> 5000 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

N -methyl- D -glucamine (abbreviation NMDG or NMG , also meglumine ) is a chemical compound thatis derivedfrom D - glucose . Instead of the aldehyde oxygen in glucose, it carries a methylamino group. The amine has a basic reaction, so the nitrogen is able to take up a proton . As a result, N -methyl- D -glucamine is partially positively charged in aqueous solution.

In electrophysiology , N -methyl- D -glucamine is used as a substitute for sodium ions (Na ⁺ ). NMDG is characterized by osmotic activity that is similar to that of sodium ions. Cell membranes are impermeable to NMDG. NMDG is also used as a sodium substitute in culture media , for example when the cultured cells are sensitive to Na ⁺ ions.

Individual evidence

1. ↑ Entry on METHYLGLUCAMINE in the CosIng database of the EU Commission, accessed on May 19, 2020.
2. ↑ ^{a b c d e f g} Data sheet N-Methyl-D-glucamine (PDF) from Merck , accessed on December 25, 2019.