N , N -dimethyl-3- (10,10-dimethyl-9,10-dihydroanthracen-9-ylidene) propylamine
|External identifiers / databases|
245–248 ° C (melitracen hydrochloride)
|As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .|
Melitracen is a tricyclic antidepressant with the pharmacological properties characteristic of this group. It is particularly similar to amitriptyline . In doses less than 150 mg, it is non- sedating .
Melitracen is used in fixed combination with flupentixol ( Deanxit ® ; 10 mg melitracen and 0.5 mg flupentixol) for the treatment of mild to moderate states of depressive inhibition and anxiety. Deanxit has a mood-enhancing and anxiety-relieving effect and is suitable for the treatment of mild to moderate depression , which is characterized by anxiety , loss of the ability to be happy, fruitless brooding , fear of failure and feelings of guilt . Also used to treat trigeminal - Neuralgia , neuroses and aphthous ulcers combining Melitracen / flupentixol was proposed.
Melitracene is synthesized in several stages starting from anthrone .
- Entry on Melitracen. In: Römpp Online . Georg Thieme Verlag, accessed on September 29, 2014.
- This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- A. Kleemann , J. Engel, B. Kutscher, D. Reichert: Pharmaceutical Substances - Synthesis, Patents, Applications , 4th edition, Thieme-Verlag, Stuttgart 2000, ISBN 978-1-58890 -031-9 .
- H. Hager: Hager's handbook of pharmaceutical practice . Follow. 1-3, Springer, 1999, ISBN 3-540-62646-8 .