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Structural formula
Structural formula of melitracen
Non-proprietary name Melitracene
other names

N , N -dimethyl-3- (10,10-dimethyl-9,10-dihydroanthracen-9-ylidene) propylamine

Molecular formula
  • C 21 H 25 N
  • C 21 H 25 N · HCl (hydrochloride)
External identifiers / databases
CAS number
  • 5118-29-6 (melitracene)
  • 10563-70-9 (melitracene hydrochloride )
EC number 225-858-5
ECHA InfoCard 100.023.507
PubChem 25382
ChemSpider 23697
DrugBank DB13384
Wikidata Q411251
Drug information
ATC code
Drug class


Molar mass
  • 291.43 g · mol -1
  • 327.90 g mol −1 (hydrochloride)
Physical state


Melting point

245–248 ° C (melitracen hydrochloride)

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
Toxicological data
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Melitracen is a tricyclic antidepressant with the pharmacological properties characteristic of this group. It is particularly similar to amitriptyline . In doses less than 150 mg, it is non- sedating .

Melitracen was patented by Kefalas A / S in 1963 and is used in Europe together with the neuroleptic flupentixol as a combination preparation in the drug Deanxit ® .


Melitracen is used in fixed combination with flupentixol ( Deanxit ® ; 10 mg melitracen and 0.5 mg flupentixol) for the treatment of mild to moderate states of depressive inhibition and anxiety. Deanxit has a mood-enhancing and anxiety-relieving effect and is suitable for the treatment of mild to moderate depression , which is characterized by anxiety , loss of the ability to be happy, fruitless brooding , fear of failure and feelings of guilt . Also used to treat trigeminal - Neuralgia , neuroses and aphthous ulcers combining Melitracen / flupentixol was proposed.

In Germany there are no drugs with the medicinal substance melitracen on the market.

Side effects

The adverse effects include dry mouth, accommodation disorders, tachycardia , hyperhidrosis and orthostatic complaints.


Melitracene is synthesized in several stages starting from anthrone .

Individual evidence

  1. a b Entry on Melitracen. In: Römpp Online . Georg Thieme Verlag, accessed on September 29, 2014.
  2. This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  3. ^ A b c d e f g A. Kleemann , J. Engel, B. Kutscher, D. Reichert: Pharmaceutical Substances - Synthesis, Patents, Applications , 4th edition, Thieme-Verlag, Stuttgart 2000, ISBN 978-1-58890 -031-9 .
  4. a b H. Hager: Hager's handbook of pharmaceutical practice . Follow. 1-3, Springer, 1999, ISBN 3-540-62646-8 .