Michael F. Holick

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Michael F. Holick

Michael F. Holick (* 1946 ) is an American doctor and biochemist. His research focus is on vitamin D research . Holick identified both calcidiol , the main circulating form of vitamin D, and calcitriol , the active form of vitamin D. His scientific work laid the foundation for new diagnostics and therapeutics for vitamin D-associated diseases.

Professional Activities

After completing his Ph.D. in biochemistry and medical degrees, he completed a Research Postdoctoral Fellowship at the University of Wisconsin , Madison. His specialty training (residency) in internal medicine completed Holick at the Massachusetts General Hospital (University Hospital of Harvard Medical School ) in Boston .

He is an endocrinologist and professor of medicine , physiology, and biophysics, and director of the Bone Health Care Clinic and the Heliotherapy, Light, and Skin Research Center at Boston University Medical Center. There he offers extensive evaluation and treatment programs for children and adults with various metabolic bone diseases including osteoporosis , osteomalacia , stress fractures in young athletes and atraumatic fractures in children and for patients with hypermobility syndromes , osteogenesis imperfeci and Ehlers-Danlos syndrome . He was also director of the General Clinical Research Unit at Boston University for several years.

Michael F. Holick holds various management positions, including a. in the NASA / Chair Standing Review Panel-Human Research Program, Chair NIDDK Special Emphasis Panel Review Meeting, Chair Endocrine Practice Guidelines Committee for Vitamin D, and is Editor-In-Chief of the Journal of Clinical Laboratory.

Scientific achievements and research results

Holick made important discoveries in the area of vitamin D , which led to new therapies for diseases of the bone metabolism, hypocalcemia and psoriasis . He wrote in more than 400 publications on the biochemistry, physiology, metabolism and photobiology of vitamin D and the pathophysiology of vitamin D deficiency.

He discussed that vitamin D deficiency not only plays a role in the development of metabolic bone disease and osteoporosis in adults, but also the risk of children and adults for common tumors , autoimmune diseases , including type 1 diabetes mellitus and multiple sclerosis , as well as heart disease increased.

As a graduate student, he identified the major circulating form of vitamin D, 25-hydroxycholecalciferol ( calcidiol ), which is measured to determine a patient's vitamin D status, and identified the active form of vitamin D, 1α, 25-dihydroxycholecalciferol ( Calcitriol ), as well as other metabolites, including 24,25-dihydroxyvitamin D3, 1,24,25-trihydroxyvitamin D3 and 25,26-dihydroxyvitamin D3.

As a fellow he participated in the first chemical synthesis of calcitriol and 1α-hydroxyvitamin D3, which was used for the first time in the treatment of renal osteodystrophy , hypoparathyroidism , vitamin D-dependent rickets type I and osteoporosis . He also clarified the pathophysiology of hereditary vitamin D-dependent rickets , which is based on a disturbed vitamin D metabolism , as well as the pathophysiological mechanisms of X-linked hypophosphatmetic rickets.

Michael F. Holick helped develop the first clinical assays for calcidiol and calcitriol and showed how vitamin D3 is synthesized in the skin through exposure to the sun and determined how the season, time of day, skin pigmentation, use of sunscreen and the latitude of this vital skin process influence.

He found that not only is the skin the only organ that produces vitamin D, but it is also a target tissue for the active form of vitamin D, calcitriol. He determined the extremely inhibitory effects of calcitriol on the proliferation of keratinocytes and the beneficial effects on differentiation and implemented these observations by showing that the topical application of calcitriol and several of its analogues were effective in the treatment of psoriasis.

He showed that macrophages and prostate cells have the enzymatic equipment to be able to produce calcitriol and found that the extrarenal production of calcitriol should play a decisive role not only in cancer prevention but also in the regulation of the immune system .

He developed a vitamin D absorption test and demonstrated that vitamin D is bioavailable in orange juice, which led to the controversial addition to orange juice in the United States. He also used this test to show that the main reason for vitamin D deficiency in obesity is the storage of vitamin D in adipose tissue.

He helped with vitamin D top-up studies to understand how much vitamin D is needed to keep blood calcidiol levels in adults within an effective range; no toxicity was found with up to 10,000 IU of vitamin D per day for 5 months .

reception

His work was received and described in magazines and specialist journals.

Awards

Holick has received numerous awards for his work in the field of vitamin D research, including the Merit Award from the National Institute of Health, the First ASBMR Fuller Albright Award, the Mead Johnson Award, the Osborne and Mendel Award, the McCollum Award, the Robert H. Herman Award from the American Society for Clinical Nutrition, the ACN Award from the American College of Nutrition, the NIH's General Clinical Research Center's Program Award for Excellence in Clinical Research, the Psoriasis Research Achievement Award from the American Skin Association, the DSM Innovation in Nutrition Award, the Van Slyke Award from American Association for Clinical Chemistry, the Linus Pauling Prize In Human Nutrition, the Delbert A Fisher Research Scholar Award from the Endocrine Society, and the American College of Nutrition's Communication Media Award.

Publications

Holick is the author of more than 400 scientific publications on the biochemistry, physiology, metabolism and photobiology of vitamin D and the pathophysiology of vitamin D deficiency, among others

  • Vitamin D deficiency. In: The New England journal of medicine . Volume 357, Number 3, July 2007, pp. 266-281, doi : 10.1056 / NEJMra070553 . PMID 17634462 .
  • Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health. In: The American journal of clinical nutrition. Volume 77, Number 6, June 2003, pp. 1478-1483, PMID 12791627 .
  • Efficacy and safety of topical calcitriol (1,25-dihydroxyvitamin d3) for the treatment of psoriasis. In: British Journal of Dermatology . Volume 134, Number 2, February 1996, pp. 238-246, PMID 8746336 .
  • Age, vitamin D, and solar ultraviolet. In: The Lancet . Volume 2, Number 8671, November 1989, pp. 1104-1105, PMID 2572832 .
  • Photosynthesis of previtamin D3 in human skin and the physiologic consequences. In: Science . Volume 210, Number 4466, October 1980, pp. 203-205, PMID 6251551 .
  • Isolation and identification of 25-hydroxycholecalciferol from human plasma. In: Archives of Internal Medicine . Volume 129, Number 1, January 1972, pp. 56-61, PMID 4332591 .
  • Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine. In: Biochemistry . Volume 10, Number 14, July 1971, pp. 2799-2804. PMID 4326883 .

Holick also wrote several books on the subject, highlighting the importance of vitamin D and its numerous health benefits, making it known to the general public and discussing the benefits of moderate and the risks of excessive sun exposure.

Books (selection)

Web links

Individual evidence

  1. ^ MF Holick, HF Deluca, LV Avioli: Isolation and identification of 25-hydroxycholecalciferol from human plasma . In: Archives of Internal Medicine . 129, No. 1, 1972, pp. 56-61. doi : 10.1001 / archinte.1972.00320010060005 . PMID 4332591 .
  2. ↑ MF Holick, HK Schnoes, HF Deluca, T Suda, RJ Cousins: Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine . In: Biochemistry . 10, No. 14, 1971, pp. 2799-804. doi : 10.1021 / bi00790a023 . PMID 4326883 .
  3. ↑ a b c med.harvard.edu - Biographical Sketch MF Holick (PDF; 204 kB) Archived from the original on June 27, 2010. Retrieved on June 11, 2012.
  4. ^ Boston University School of Medicine, Michael F. Holick Ph.D., MD . Archived from the original on June 10, 2012. Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Retrieved June 11, 2012. @1@ 2Template: Webachiv / IABot / www.bumc.bu.edu
  5. ^ Vitamin D and Bone Metabolism Unit at Boston University . Retrieved June 11, 2012.
  6. ^ Human Research Program 2010 Chair Standing Review Panel Meeting (PDF; 104 kB) Accessed June 11, 2012.
  7. ↑ Study of Topical Calcitriol or Oral Calcitriol in Patients With Psoriasis. NIDDK, Chair MF Holick . Retrieved June 11, 2012.
  8. ^ MF Holick, NC Binkley, HA Bischoff-Ferrari, CM Gordon, DA Hanley, RP Heaney, MH Murad, CM Weaver: Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. In: The Journal of clinical endocrinology and metabolism. Volume 96, Number 7, July 2011, ISSN  1945-7197 , pp. 1911-1930, doi : 10.1210 / jc.2011-0385 . PMID 21646368 .
  9. ^ Journal of Clinical Laboratory - Editorial Board . Retrieved June 14, 2016.
  10. ^ MF Holick, TC Chen: Vitamin D deficiency: a worldwide problem with health consequences. . In: Am J Clin Nutr. . 87, No. 4, 2008, pp. 1080S-6S. PMID 18400738 .
  11. ↑ a b MF Holick: Vitamin D deficiency . In: The New England Journal of Medicine . 357, No. 3, 2007, pp. 266-81. doi : 10.1056 / NEJMra070553 . PMID 17634462 .
  12. ^ MF Holick, HF Deluca, LV Avioli: Isolation and identification of 25-hydroxycholecalciferol from human plasma . In: Archives of Internal Medicine . 129, No. 1, 1972, pp. 56-61. doi : 10.1001 / archinte.1972.00320010060005 . PMID 4332591 .
  13. ^ BW Hollis: Assessment of vitamin D nutritional and hormonal status: what to measure and how to do it. . In: Cacif Tissue Int. . 58, No. 1, 1996, pp. 4-5. doi : 10.1007 / BF02509538 . PMID 8825231 .
  14. ↑ MF Holick, HK Schnoes, HF Deluca, T Suda, RJ Cousins: Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine . In: Biochemistry . 10, No. 14, 1971, pp. 2799-804. doi : 10.1021 / bi00790a023 . PMID 4326883 .
  15. ↑ MF Holick, HK Schnoes, HF Deluca, RW Gray, IT Boyle, T Suda: Isolation and identification of 24,25-dihydroxycholecalciferol, a metabolite of vitamin D made in the kidney . In: Biochemistry . 11, No. 23, 1972, pp. 4251-5. doi : 10.1021 / bi00773a009 . PMID 4342902 .
  16. ↑ MF Holick, A Kleiner-Bossaller, HK Schnoes, PM Kasten, IT Boyle, HF Deluca: 1,24,25-trihydroxyvitamin D3. A metabolite of vitamin D3 effective on intestine . In: The Journal of Biological Chemistry . 248, No. 19, 1973, pp. 6691-6. PMID 4355503 .
  17. ↑ HF Deluca, T Suda, HK Schnoes, Y Tanaka, MF Holick: 25,26-dihydroxycholecalciferol, a metabolite of vitamin D3 with intestinal calcium transport activity . In: Biochemistry . 9, No. 24, 1970, pp. 4776-80. doi : 10.1021 / bi00826a022 . PMID 4319987 .
  18. ^ Nutrition classics. Proceedings of the National Academy of Sciences . Volume 68, 1971, pages 803-804. "Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine" by MFHolick, HK Schnoes and HFDeluca . In: Nutrition Reviews . 38, No. 5, 1980, pp. 190-2. PMID 7010230 .
  19. ↑ M. Holick, S. Holick, T Tavela, B Gallagher, H. Schnoes, H. Deluca: Synthesis of (6-3H) -1alpha-hydroxyvitamin D3 and its metabolism in vivo to (3H) -1alpha, 25-dihydroxyvitamin D3 . In: Science . 190, No. 4214, 1975, pp. 576-8. doi : 10.1126 / science.1188356 . PMID 1188356 .
  20. ↑ DS Silverberg, KB Bettcher, JB Dossetor, TR Overton, MF Holick, HF Deluca: Effect of I, 25-dihydroxycholecalciferol in renal osteodystrophy . In: Canadian Medical Association journal . 112, No. 2, 1975, pp. 190, 193-5. PMID 1111876 . PMC 1956416 (free full text).
  21. ↑ Sang Whay Kooh, Donald Fraser, Hector F. DeLuca, Michael F. Holick, Richard E. Belsey, Mary B. Clark, Timothy M. Murray: Treatment of hypoparathyroidism and pseudohypoparathyroidism with Metabolites of vitamin D: Evidence for Impaired conversion of 25 hydroxyvitamin D to 1α, 25-dihydroxyvitamin D . In: New England Journal of Medicine . 293, No. 17, 1975, pp. 840-4. doi : 10.1056 / NEJM197510232931702 . PMID 170516 .
  22. ↑ RM Neer, MF Holick, HF Deluca, JT Potts: Effects of 1α-hydroxy-vitamin D3 and 1,25-dihydroxy-vitamin D3 on calcium and phosphorus metabolism in hypoparathyroidism . In: Metabolism . 24, No. 12, 1975, pp. 1403-1413. doi : 10.1016 / 0026-0495 (75) 90055-4 . PMID 1196134 .
  23. ↑ S Balsan, M Garabedian, R Sorgniard, MF Holick, HF Deluca: 1,25-dihydroxyvitamin D3 and 1, alpha-hydroxyvitamin D3 in children: Biologic and therapeutic effects in nutritional rickets and different types of vitamin D resistance . In: Pediatric research . 9, No. 7, 1975, pp. 586-93. doi : 10.1203 / 00006450-197507000-00007 . PMID 169507 .
  24. ↑ MF Holick: Optimal vitamin D status for the prevention and treatment of osteoporosis . In: Drugs & Aging . 24, No. 12, 2007, pp. 1017-1029. doi : 10.2165 / 00002512-200724120-00005 . PMID 18020534 .
  25. ↑ Donald Fraser, Sang Whay Kooh, H. Peter Kind, Michael F. Holick, Yoko Tanaka, Hector F. Deluca: Pathogenesis of Hereditary Vitamin-D-Dependent Rickets . In: New England Journal of Medicine . 289, No. 16, 1973, pp. 817-22. doi : 10.1056 / NEJM197310182891601 . PMID 4357855 .
  26. ↑ FH Glorieux, MF Holick, CR Scriver, HF Deluca: X-linked hypophosphatemic rickets: Inadequate therapeutic response to 1,25-dihydroxycholecalciferol . In: Lancet . 2, No. 7824, 1973, pp. 287-9. PMID 4124774 .
  27. ↑ TL Clemens, JS Adams, JM Nolan, MF Holick: Measurement of circulating vitamin D in man . In: Clinica Chimica Acta . 121, No. 3, 1982, pp. 301-8. PMID 6286167 .
  28. ↑ a b M. F. Holick, JA MacLaughlin, MB Clark, SA Holick, JT Potts, RR Anderson, IH Blank, JA Parrish, P. Elias: Photosynthesis of previtamin D3 in human skin and the physiologic consequences. In: Science. Volume 210, Number 4466, October 1980, ISSN  0036-8075 , pp. 203-205, doi : 10.1126 / science.6251551 , PMID 6251551 .
  29. ^ AR Webb, L Kline, MF Holick: Influence of season and latitude on the cutaneous synthesis of vitamin D3: Exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin . In: J Clin Endocrinol Metab. . 67, No. 2, 1988, pp. 273-8. doi : 10.1210 / jcem-67-2-373 . PMID 2839537 .
  30. ^ Z Lu, TC Chen, MF Holick: Influence of season and time of day on the synthesis of vitamin D3. In: Holick MF, Kligman A, eds. Proceedings of the Biologic Effects of Light Symposium . Walter De Gruyter & Co, Berlin, 1992, pp. 53-56.
  31. ↑ TL Clemens, JS Adams, SL Henderson, MF Holick: Increased skin pigment Reduces the capacity of the skin to synthesize vitamin D . In: Lancet . 1, No. 8263, 1982, pp. 74-6. doi : 10.1016 / S0140-6736 (82) 90214-8 . PMID 6119494 .
  32. ↑ LY Matsuoka, L Ide, J Wortsman, JA MacLaughlin, MF Holick: Sunscreens suppress cutaneous vitamin D3 synthesis . In: J Clin Endocrinol Metab. . 64, No. 6, 1987, pp. 1165-8. doi : 10.1210 / jcem-64-6-1165 . PMID 3033008 .
  33. ^ AR Webb, L Kline, MF Holick: Influence of season and latitude on the cutaneous synthesis of vitamin D3: Exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin . In: J Clin Endocrinol Metab. . 67, No. 2, 1988, pp. 273-8. doi : 10.1210 / jcem-67-2-373 . PMID 2839537 .
  34. ↑ a b EL Smith, NC Walworth, MF Holick: Effect of 1 alpha, 25-dihydroxyvitamin D3 on the morphologic and biochemical differentiation of cultured human epidermal keratinocytes grown in serum-free conditions. . In: J Ivest Dermatol. . 86, No. 6, 1986, pp. 709-14. doi : 10.1111 / 1523-1747.ep12276343 . PMID 2423618 .
  35. ↑ A Pèrez, TC Chen, A Turner, R Raab, J Bhawan, P Poche, MF Holick: Efficacy and safety of topical calcitriol (1,25-dihydroxyvitamin d3) for the treatment of psoriasis . In: Br J Dermatol. . 134, No. 2, 1996, pp. 238-46. doi : 10.1111 / j.1365-2133.1996.tb07608.x . PMID 8746336 .
  36. ↑ JS Adams, FR Singer, MA Dacad, OP Sharma, MJ Hayes, P Vouros, MF Holick: Isolation and structural identification of 1,25-dihydroxyvitamin D3 produced by cultured alveolar macrophages in sarcoidosis . In: J Clin Endocrinol Metab. . 60, No. 5, 1985, pp. 960-6. doi : 10.1210 / jcem-60-5-960 . PMID 2984238 .
  37. ↑ GG Schwartz, LW Whitlatch, TC Chen, BL Lokeshwar, MF Holick: Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3 . In: Cancer Epiodemiol Biomarkers Prev. . 7, No. 5, 1998, pp. 391-5. PMID 9610788 .
  38. ^ MF Holick: Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease . In: Am J Clin Nutr. . 80, No. 6, 2004, pp. 1678S-88S. PMID 15585788 .
  39. ↑ FA Farraye, H. Nimitphong, A. Stucchi, K. Dendrinos, AB Boulanger, A. Vijjeswarapu, A. Tannenbaum, R. Biancuzzo, TC Chen, MF Holick: absorption Use of a novel vitamin D bioavailability test demons trates did vitamin D is decreased in patients with quiescent Crohn's disease. In: Inflammatory bowel diseases. Volume 17, number 10, October 2011, ISSN  1536-4844 , pp. 2116-2121, doi : 10.1002 / ibd.21595 . PMID 21910173 .
  40. ↑ V Tangpricha, P Koutkia, SM Rieke, TC Chen, AA Perez, MF Holick: Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health. . In: Am J Clin Nutr. . 77, No. 6, 2003, pp. 1478-1483. PMID 12791627 .
  41. ↑ The Vitamin D Legend Die Welt, February 7, 2016
  42. ^ J Wortsman, LY Matsuoka, TC Chen, Z Lu, MF Holick: Decreased bioavailability of vitamin D in obesity. . In: Am J Clin Nutr. . 72, No. 3, 2000, pp. 690-693. PMID 10966885 .
  43. ^ RP Heaney, KM Davies, TC Chen, MF Holick, MJ Barger-Lux: Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. . In: Am J Clin Nutr. . 78, No. 5, 2003, pp. 496-497. PMID 12499343 .
  44. ↑ Dr. Sunshine . Retrieved June 11, 2012.
  45. ↑ Update on Fibromyalgia and Vitamin D . Retrieved June 11, 2012.
  46. ↑ Why You Should Be Getting More Sun . Retrieved June 11, 2012.
  47. ^ The nature of nutrients . Archived from the original on January 25, 2012. Retrieved June 11, 2012.
  48. ↑ Get some sun . Retrieved June 11, 2012.
  49. ^ Scientific American - The Vitamin D and sun debate . Retrieved June 11, 2012.
  50. ^ Bibliography MF Holick . Retrieved June 11, 2012.
  51. ^ The UV advantage - biography - awards . Archived from the original on September 3, 2011. Retrieved June 11, 2012.
  52. ↑ DSM Nutrition Award 2009 presented to Michael Holick and Heike Bischoff-Ferrari . Retrieved June 11, 2012.
  53. ^ American Association for Clinical Chemistry - 2010 Van Slyke Award . Retrieved June 11, 2012.
  54. ↑ 2009 Linus Pauling Institute Prize Recipient . Retrieved June 11, 2012.
  55. ↑ Dr. Holick honored by the Endocrine Society . Retrieved June 11, 2012.
  56. ↑ BUSM professor receives 2011 ACN Communication Media Award . Retrieved June 11, 2012.
  57. ^ Harvard Catalyst Profiles . Archived from the original on April 24, 2012. Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Retrieved June 11, 2012. @1@ 2Template: Webachiv / IABot / connects.catalyst.harvard.edu
  58. ^ Books - Michael F. Holick . Retrieved June 11, 2012.
  59. ↑ including MF Holick: The Vitamin D Solution: A 3-Step Strategy to Cure Our Most Common Health Problems . Plume 1st edition, 2011, ISBN 978-0-452-29688-6 .
personal data
SURNAME Holick, Michael F.
BRIEF DESCRIPTION American physician and biochemist
DATE OF BIRTH 1946