Minor J. Coon

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Minor Jesser "Jud" Coon (born July 29, 1921 in Englewood , Colorado ; † September 5, 2018 ) was an American biochemist at the University of Michigan .

Coon earned a bachelor's degree from the University of Colorado in 1943 and a Ph.D. in 1946 for The amino acid requirements of man. with William C. Rose at the University of Illinois . He stayed here initially as a postdoctoral fellow . From 1947 Coon was an instructor in the department of biochemistry on the faculty of the University of Pennsylvania , where he was assistant professor in 1949 and associate professor in 1953 . In 1955 he received a full professorship in biochemistry at the University of Michigan Medical School . From 1970 to 1990 he was head of the department for biochemistry there. Two sabbaticals took him in 1955 to the later Nobel Prize winner Severo Ochoa at New York University and in 1961/62 to the later Nobel Prize winner Vladimir Prelog at the ETH Zurich . At the University of Michigan Coon was (as of 2017) Victor V. Vaughan Distinguished University Professor Emeritus , but since the end of 2003 he no longer had his own laboratory.

Coon is best known for his work on the cytochrome P450 system. In this way he was able to isolate and identify numerous enzymes of this system and NADPH cytochrome P450 oxidoreductase as well as elucidate the regulation of these enzymes. He was also able to determine the role of several P450 enzymes in the metabolism of various drugs , carcinogens and toxins .

In 1959, Coon received the American Chemical Society Award in Enzyme Chemistry from the Division of Biological Chemistry of the American Chemical Society . In 1979 Coon was the first recipient of the William C. Rose Award from the American Society for Biochemistry and Molecular Biology (ASBMB), of which he was president in 1991. In 1980 Coon received the Bernard B. Brodie Award in Drug Metabolism from the American Society for Pharmacology and Experimental Therapeutics . In 1983 he was elected to the National Academy of Sciences , 1984 to the American Academy of Arts and Sciences, and 1987 to the Institute of Medicine .

Coon was a co-editor of the scientific journals Biochemical Preparations and Microsomes, Drug Oxidations and Chemical Carcinogenesis , Biochemistry , Molecular Pharmacology, and the Journal of Biological Chemistry .

Archives of Biochemistry and Biophysics dedicated an entire issue to Coon on his 90th birthday. At the University of Michigan there was a Minor J. Coon Professorship in Biological Chemistry since 1991 , the last position holder was William L. Smith until 2015 , his predecessor was Jack E. Dixon from 1991 to 2003 .

literature

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Individual evidence

  1. ↑ F. Peter Guengerich: Guest Editor's Introduction. In: Archives of Biochemistry and Biophysics. 507, 2011, pp. 1–2, doi : 10.1016 / j.abb.2011.01.026 .
  2. ^ Obituary , accessed on September 16, 2018
  3. ↑ Pfizer Award in Enzyme Chemistry (PDF; 48 kB) from the Division of Biological Chemistry (divbiolchem.org); accessed on January 3, 2018.
  4. ^ William C. Rose Award. In: asbmb.org. Retrieved January 3, 2018 .
  5. ^ ASBMB Presidents: 1991 - Minor J. Coon. In: asbmb.org. Retrieved January 3, 2018 .
  6. ^ ASPET - Bernard B. Brodie Award in Drug Metabolism. In: aspet.org. April 21, 2017, accessed January 3, 2018 .
  7. ↑ Minor Coon. In: nasonline.org. Retrieved January 3, 2018 .
  8. ↑ Book of Members 1780 – present, Chapter C. (PDF; 1.3 MB) In: American Academy of Arts and Sciences (amacad.org). Retrieved January 3, 2018 .
  9. ^ Archives of Biochemistry and Biophysics - Volume 507, No. 1, pp. 1-204, (March 1, 2011). In: sciencedirect.com. Retrieved January 3, 2018 .
personal data
SURNAME Coon, Minor J.
ALTERNATIVE NAMES Coon, Minor Jesser; Coon, Minor; Coon, Jud
BRIEF DESCRIPTION American biochemist
DATE OF BIRTH July 29, 1921
PLACE OF BIRTH Englewood , Colorado
DATE OF DEATH September 6, 2018