Molinate

Structural formula
General
Surname	Molinate
other names	S -Ethyl- N -hexahydro-1 H -azepinthiolcarbamat; S-ethyl azepane-1-carbothioate; Ordram;
Molecular formula	C 9 H 17 NOS
Brief description	flammable, not very volatile liquid
External identifiers / databases
EC number	218-661-0
ECHA InfoCard	100.016.965
PubChem	16653
Wikidata	Q1943471
properties
Molar mass	187.31 g mol −1
Physical state	liquid
density	1.063 g cm −3
Melting point	−25 ° C
boiling point	136.5 ° C (13 mbar); 355 ° C;
Vapor pressure	0.0074 mbar (25 ° C)
solubility	sparingly soluble in water (1.1 g · l -1 ); miscible with methanol, acetone, ethyl acetate and hexane;
safety instructions
H and P phrases	H: 302-332-317-351-361f-373-410
	P: 201-273-280-301 + 312 + 330-304 + 340 + 312-308 + 313
Toxicological data	369 mg kg −1 ( LD 50 , rat , oral ) ; 3,536 mg kg −1 ( LD 50 , rabbit , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Molinat is an active ingredient for crop protection and a chemical compound from the group of derivatives of thiocarbamates .

Extraction and presentation

Molinate can be obtained by reacting phosgene with ethyl mercaptan and further reacting the intermediate product ethyl chlorothiol formate with hexamethyleneimine .

properties

Molinate is a yellowish liquid that is difficult to ignite. It is stable under acidic and alkaline conditions.

use

Molinat is used as an active ingredient in crop protection products. It is a selective herbicide and is used to control weeds in rice fields. It is toxic to germinating broad-leaved weeds and grasses. The effect is based on the inhibition of lipid synthesis . Molinate was introduced in the United States in 1964.

Admission

Molinat was approved in the EU as an active ingredient in plant protection products with effect from August 1, 2004, but this approval expired on July 31, 2014. The transition period ended on January 31, 2016. Since then, no pesticides containing this active ingredient have been approved in any of the EU countries including Germany, Austria or Switzerland.

safety instructions

The vapors of Molinat can form an explosive mixture with air when the substance is heated above its flash point (100 ° C).

Web links

Review report for the active substance molinate (PDF; 268 kB), June 3, 2003.

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Entry on Molinat in the GESTIS substance database of the IFA , accessed on January 8, 2020(JavaScript required) .
↑ ^a ^b ^c ^d Entry on Molinate in the Pesticide Properties DataBase (PPDB) of the University of Hertfordshire , accessed on August 1, 2013.
↑ Molinate data sheet at Sigma-Aldrich , accessed on May 20, 2017 ( PDF ).

↑ Entry on Molinate in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

↑ Thomas A. Unger: Pesticide synthesis handbook . 1996, ISBN 978-0-8155-1401-5 , pp. 112 ( limited preview in Google Book search).

↑ ^a ^b Terence Robert Roberts, DH Hutson: Metabolic pathways of agrochemicals, Volume 2 . Royal Soc of Chemistry, 1999, ISBN 978-0-85404-499-3 , pp. 599 ( limited preview in Google Book search).

↑ entry molinate at Extoxnet.

↑ Directive 2003/81 / EC of the Commission dated September 5, 2003 amending Council Directive 91/414 / EEC to include the active substances Molinat, Thiram and Ziram (PDF) .

↑ General Directorate Health and Food Safety of the European Commission: Entry on Molinate in the EU pesticide database ; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 8, 2016.

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Entry on Molinat in the GESTIS substance database of the IFA , accessed on January 8, 2020(JavaScript required) .

[herts-2] Entry on Molinate in the Pesticide Properties DataBase (PPDB) of the University of Hertfordshire , accessed on August 1, 2013.

[Sigma-3] Molinate data sheet at Sigma-Aldrich , accessed on May 20, 2017 ( PDF ).

[CLP_100.016.965-4] Entry on Molinate in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[Unger-5] Thomas A. Unger: Pesticide synthesis handbook . 1996, ISBN 978-0-8155-1401-5 , pp. 112 ( limited preview in Google Book search).

[Roberts2-6] Terence Robert Roberts, DH Hutson: Metabolic pathways of agrochemicals, Volume 2 . Royal Soc of Chemistry, 1999, ISBN 978-0-85404-499-3 , pp. 599 ( limited preview in Google Book search).

[cornell-7] try molinate at Extoxnet.

[8] Directive 2003/81 / EC of the Commission dated September 5, 2003 amending Council Directive 91/414 / EEC to include the active substances Molinat, Thiram and Ziram (PDF) .

[PSM-9] General Directorate Health and Food Safety of the European Commission: Entry on Molinate in the EU pesticide database ; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 8, 2016.