Sodium picosulfate

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Structural formula
Structural formula of sodium picosulfate
General
Non-proprietary name Sodium picosulfate
other names
  • Disodium 4,4 '- (2-pyridylmethylene) diphenyl bis (sulfate) ( IUPAC )
  • Natrii picosulfas ( Latin )
Molecular formula C 18 H 13 NNa 2 O 8 S 2
Brief description

White to almost white, crystalline powder

External identifiers / databases
CAS number 10040-45-6
EC number 233-120-9
ECHA InfoCard 100.030.097
PubChem 68654
ChemSpider 61910
DrugBank DB09268
Wikidata Q410265
Drug information
ATC code

A06 AB08

Drug class

Laxatives

properties
Molar mass 481.41 g · mol -1
Physical state

firmly

Melting point

272–275 ° C (decomposition)

solubility

slightly soluble in water, poorly soluble in ethanol 96%

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
Toxicological data

17 g kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sodium picosulphate is a medicinal substance and belongs to the class of laxatives . It can be used for a short time in the case of constipation and diseases that require easier bowel movements .

The desired effect occurs approximately 6 to 12 hours after oral administration.

Mechanism of action

The mechanism of action of sodium picosulfate is the same as that of bisacodyl . It differs from the latter in that sodium picosulfate does not pass through the enterohepatic cycle . Therefore, the action of sodium picosulfate occurs more quickly.

In the large intestine , sodium picosulfate, similar to bisacodyl, is converted by intestinal bacteria into free diphenols, which are the actually active substance.

Side effects

The long-published electrolyte shifts in the serum could not be observed even after decades of use; habituation occurs only very rarely, even after years of use. The motor effect can lead to cramp-like abdominal pain.

The use of suppositories containing sodium picosulfate can cause pain and bleeding in the rectum area .

Trade names

Monopreparations

Agaffin laxative gel, coated tablets and drops (A); Agiolax Pico laxative lozenges (D); Agiopic laxative lozenges (A); Darmol Pico tablets (D); Dulcolax NP drops (D); Dulcolax Picosulfate and Pearls (CH); Fructines (CH); Guttalax drops and pearl capsules (A); Laxasan (CH); Laxans Drops (D), Laxasan Drops (A); Laxoberal laxative pearls, tablets and drops (D); Laxoberon (CH); Regulax laxative cube picosulfate and picosulfate drops (D); Generics (D)

Combination preparations

CitraFleet (with magnesium oxide ) (D); PICOPREP (with magnesium oxide) (D)

Individual evidence

  1. ↑ a b Data sheet SODIUM PICOSULFATE CRS (PDF) at EDQM , accessed on April 12, 2009.
  2. ↑ a b Entry on sodium picosulfate. In: Römpp Online . Georg Thieme Verlag, accessed on November 10, 2014.
  3. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  4. ↑ Technical information for Dulcolax ® Picosulfat Drops from BOEHRINGER INGELHEIM in the Swiss Medicines Compendium ® - October 16, 2008.
  5. ↑ awmf.org: S2k guidelines for chronic constipation: definition, pathophysiology, diagnostics and therapy ( memento of the original dated August 22, 2017 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. (PDF; 588 kB); Status: February 2013. @1@ 2Template: Webachiv / IABot / www.awmf.org