Philippe Schmitt-Kopplin

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Philippe Schmitt-Kopplin is a scientist who focuses on the chemical characterization of complex organic systems using methods of instrumental analysis .

Career

After studying engineering from 1987 to 1990 at the Ecole Nationale Supérieure d´Agronomie et des Industries Alimentaires (ENSAIA) at the Institut National Polytechnique de Lorraine (INPL) in Nancy , Schmitt-Kopplin received his doctorate in 1995 from the Technical University of Munich (TUM) on Institute for Ecological Chemistry (IÖC, headed by Antonius Kettrup ) of the GSF (today Helmholtz Zentrum München ). He spent his postdoctoral time in the USA on a fellowship from the US National Research Council, at the US Environmental Protection Agency , Athens, Georgia on capillary electrophoresis and chirality in environmental chemistry . From 1996 to 2001 he worked as a junior researcher at the IÖC of the GSF in Attaching . In 2001 he took over the management of the BioGeomics working group, in 2009 the management of the BioGeoChemistry and Analytics department at the IÖC and from 2011 the independent Analytical Biogeochemistry (BGC) department. Schmitt-Kopplin is also Professor in the Chair for Analytical Food Chemistry at TUM at the Weihenstephan Science Center and Adjunct Professor at the University of Maryland Center for Environmental Science at the Chesapeake Biological Laboratory in Solomons, USA.

Scientific focus

Schmitt-Kopplin combines various high-resolution analytical methods such as mass spectrometry (including FT-ICR-MS ) and NMR with different separation methods such as capillary electrophoresis and UHPLC . The amount of data obtained in this way are correspondingly statistically / mathematically processed and allow to mainly based on small molecules , the characterization of complex biological ( metabolomics ) and geological systems (organic geochemistry). One focus is the chemistry of microbiomes / holobionts and thus the study of the influences of microbial activities on the environment and health and their connection with medical and biological metadata. A better understanding of processes and system relationships at the chemical level, as well as the identification of new biomarkers, is sought.

Examples of Schmitt-Kopplin's fields of activity are the acquisition of knowledge in the field of the chemistry of the intestinal microbiome , its regulation by means of nutrition or by means of probiotic modulators for asthma / allergies and cholesterol metabolism. In the field of food chemistry , his focus is on thermal processes (including Maillard chemistry) and fermentation processes (analysis of champagne , wine and distillates ). In the field of environmental chemistry , he pursues topics such as the formation of halogenated pollutants in drinking or ballast water processing, the eutrophication of natural ecosystems or the bioactivity and chemistry of aerosols (natural and anthropogenic). B. the clarification of the effects of fine dust on herpes virus infections. Natural carbon and sulfur cycles are sampled and studied in many extreme / natural biogeosystems ( arid , hydrothermal, freshwater and marine ecosystems) in order to elucidate the biotic / abiotic origin and history of dissolved organic compounds. Pure abiotic complex organic systems exist in meteorites in an organic / mineral continuum ( organometallics ) and form the chemical building blocks of life. The analysis in extraterrestrial material was demonstrated in pioneering work in rock meteorites and carbonaceous meteorites such as the Murchinson meteorite .

Publications (selection)

Articles in professional journals

  • Philippe Schmitt ‐ Kopplin, Moritz Frommberger: Capillary electrophoresis – mass spectrometry: 15 years of developments and applications. In: Electrophoresis. 24, No. 22-23, 2003, pp. 3837-3867.
  • Norbert Hertkorn, Ronald Benner, Moritz Frommberger, Philippe Schmitt-Kopplin, Matthias Witt, Karl Kaiser, Antonius Kettrup, John I Hedges: Characterization of a major refractory component of marine dissolved organic matter. In: Geochimica et Cosmochimica Acta. 70, No. 12, 2006, pp. 2990-3010.
  • N Hertkorn, M Frommberger, M Witt, BP Koch, Ph Schmitt-Kopplin, EM Perdue: Natural organic matter and the event horizon of mass spectrometry. In: Analytical chemistry. 80, No. 2, 2008, pp. 8908-8919.
  • Janet Jansson, Ben Willing, Marianna Lucio, Ages Fekete, Johan Dicksved, Jonas Halfvarson, Curt Tysk, Philippe Schmitt-Kopplin: Metabolomics reveals metabolic biomarkers of Crohn's disease. In: PloS one. 4, No. 7, 2009.
  • Philippe Schmitt-Kopplin, Zelimir Gabelica, Régis D Gougeon, Agnes Fekete, Basem Kanawati, Mourad Harir, Istvan Gebefuegi, Gerhard Eckel, Norbert Hertkorn: High molecular diversity of extraterrestrial organic matter in Murchison meteorite revealed 40 years after its fall. In: Proceedings of the National Academy of Sciences. 107, No. 7, 2010, pp. 2763-2768.
  • David M Good, Petra Zurbig, Angel Argiles, Hartwig W Bauer, Georg Behrens, Joshua J Coon, Mohammed Dakna, Stephane Decramer, Christian Delles, Anna F Dominiczak, Jochen HH Ehrich, Frank Eitner, Danilo Fliser, Moritz Frommberger, Arnold Ganser, Mark A Girolami, Igor Golovko, Wilfried Gwinner, Marion Haubitz, Stefan Herget-Rosenthal, Joachim Jankowski, Holger Jahn, George Jerums, Bruce A Julian, Markus Kellmann, Volker Kliem, Walter Kolch, Andrzej S Krolewski, Mario Luppi, Ziad Massy, Michael Melter, Christian Neususs, Jan Novak, Karlheinz Peter, Kasper Rossing, Harald Rupprecht, Joost P Schanstra, Eric Schiffer, Jens-Uwe Stolzenburg, Lise Tarnow, Dan Theodorescu, Visith Thongboonkerd, Raymond Vanholder, Eva M Weissinger, Harald Mischak, Philippe Schmitt-Kopplin: Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. In: Molecular & cellular proteomics. , 2010.
  • Susanne Krug, Gabi Kastenmüller, Ferdinand Stückler, Manuela J Rist, Thomas Skurk, Manuela Sailer, Johannes Raffler, Werner Römisch-Margl, Jerzy Adamski, Cornelia Prehn, Thomas Frank, Karl-Heinz Engel, Thomas Hofmann, Burkhard Luy, Ralf Zimmermann, Franco Moritz, Philippe Schmitt-Kopplin, Jan Krumsiek, Werner Kremer, Fritz Huber, Uwe Oeh, Fabian J Theis, Wilfried Szymczak, Hans Hauner, Karsten Suhre, Hannelore Daniel: The dynamic range of the human metabolome revealed by challenges. In: The FASEB Journal. 26, No. 6, 2012, pp. 2607-2619.
  • Olga P Popova, Peter Jenniskens, Vacheslav Emel'yanenko, Anna Kartashova, Eugeny Biryukov, Sergey Khaibrakhmanov, Valery Shuvalov, Yurij Rybnov, Alexandr Dudorov, Victor I Grokhovsky, Dmitry D Badyukov, Qing-Zhu Yin, Peter S Gural, Jim Albers, Mikael Granvik, Läslo G Evers, Jacob Kuiper, Vladimir Kharlamov, Andrey Solovyov, Yuri S Rusakov, Stanislav Korotkiy, Ilya Serdyuk, Alexander V Korochantsev, Michail Yu Larionov, Dmitry Glazachev, Alexander E Mayer, Galen Gisler, Sergei V Gladkovennysky, Josh Wimpkovennysky , Matthew E Sanborn, Akane Yamakawa, Kenneth L Verosub, Douglas J Rowland, Sarah Roeske, Nicholas W Botto, Jon M Friedrich, Michael E Zolensky, Loan Le, Daniel Ross, Karen Ziegler, Tomoki Nakamura, Insu Ahn, Jong Ik Lee, Qin Zhou, Xian-Hua Li, Qiu-Li Li, Yu Liu, Guo-Qiang Tang, Takahiro Hiroi, Derek Sears, Ilya A Weinstein, Alexander S Vokhmintsev, Alexei V Ishchenko, Phillipe Schmitt-Kopplin, Norbert Hertkorn, Keisuke Nagao, Makiko K Haba, Mutsumi Komatsu, Takashi Mikouchi, Chelyabinsk Airburst Consortium: Chelyabinsk airburst, damage assessment, meteorite recovery, and characterization. In: Science. 342, No. 6162, 2013, pp. 1069-1073.
  • Hannelore Daniel, Amin Moghaddas Gholami, David Berry, Charles Desmarchelier, Hannes Hahne, Gunnar Loh, Stanislas Mondot, Patricia Lepage, Michael Rothballer, Alesia Walker, Christoph Böhm, Mareike Wenning, Michael Wagner, Michael Blaut, Philippe Schmitt-Kopplin, Bernhard Kuster , Dirk Haller, Thomas Clavel: High-fat diet alters gut microbiota physiology in mice. In: The ISME journal. 8, No. 2, 2014, p. 295.
  • Philippe Schmitt-Kopplin, Daniel Hemmler, Franco Moritz, Régis D Gougeon, Marianna Lucio, Markus Meringer, Constanze Müller, Mourad Harir, Norbert Hertkorn: Systems chemical analytics: introduction to the challenges of chemical complexity analysis. In: Faraday Discussions. 218 , 2019, pp. 9-28.

Editorships

  • Philippe Schmitt-Kopplin (Ed.): Capillary Electrophoresis. Methods and Protocols (= Methods in Molecular Biology. 1483). 2nd Edition. Springer, Berlin; Springer New York; Humana Press, 2018, ISBN 978-1-4939-6403-1 .
  • Basem Kanawati, Philippe Schmitt-Kopplin (Ed.): Fundamentals and Applications of Fourier Transform Mass Spectrometry . Elsevier, 2019, ISBN 978-0-12-814013-0 .

Web links

Individual evidence

  1. ↑ Prof. Dr. Philippe Schmitt-Kopplin. Retrieved February 11, 2019 .
  2. ↑ Chair of Analytical Food Chemistry: Foodomics Platform. Retrieved February 11, 2019 .
  3. ^ Professor Philippe Schmitt-Kopplin. September 20, 2017, accessed February 12, 2019 .
  4. ↑ New class of molecules discovered in the intestine - Helmholtz Center Munich. Retrieved February 24, 2019 .
  5. ↑ Fragile bacterial community in the intestine. Retrieved February 24, 2019 .
  6. ↑ Baby intestine remains true to its original settlement - Helmholtz Center Munich. Retrieved February 24, 2019 .
  7. ↑ Cold potatoes against complex diseases - Helmholtz Center Munich. Retrieved February 24, 2019 .
  8. ↑ Helmholtz Zentrum München: Allergies: D-Tryptophan explains probiotic properties of bacteria - Helmholtz Zentrum München. Retrieved February 24, 2019 .
  9. ↑ Cholesterol an important piece of the puzzle for fat-burning. Retrieved February 12, 2019 (American English).
  10. ^ Jeanna Bryner: Secret to Champagne Flavor is Right Under Your Nose. September 28, 2009, accessed February 12, 2019 .
  11. ↑ Champagne from the shipwreck: easy-drinking, with little alcohol. Retrieved February 24, 2019 .
  12. ↑ Fabian Lange, Cornelius Lange: Historical wine: With a long finish . ISSN  0174-4909 ( faz.net [accessed February 12, 2019]).
  13. ↑ Wine reveals oak barrels in which it matured - science up-to-date. Retrieved February 24, 2019 .
  14. ^ Terroir has influence on flavor. In: iLaddie Whiskey Nerd. October 12, 2018, accessed February 24, 2019 .
  15. ↑ Helmholtz Zentrum München: Ballast Water from Ships: Filtration Instead of Disinfection - Helmholtz Zentrum München. Retrieved February 24, 2019 .
  16. ^ Press - Helmholtz Center for Environmental Research UFZ. Retrieved February 24, 2019 .
  17. ↑ # 3: Champagne on the Merian? Retrieved on February 24, 2019 (German).
  18. ↑ Lung diseases: Fine dust wakes sleeping viruses in the lungs. In: MEDICINE ASPECTS. January 16, 2017, accessed on February 12, 2019 (German).
  19. ↑ Pia Gaupels: Snack for bacteria: the organic sulfur in the ocean - GeoHorizon. Retrieved on February 24, 2019 (German).
  20. ↑ TU Berlin: Life without water - life on Mars? Retrieved February 24, 2019 .
  21. ↑ The chemical memory of sea water: Scientists examine the biomolecules dissolved in the ocean and read them like in a history book of the sea - AWI. Retrieved February 24, 2019 .
  22. ↑ Chemical memory of seawater: Scientists examine biomolecules dissolved in the ocean and read them like a history book. Retrieved February 12, 2019 .
  23. ↑ Christine Evans-Pughe: Space rocks! Meteorite analysis and the building blocks of life. January 19, 2018, accessed February 24, 2019 (American English).
  24. ↑ Helmholtz Zentrum München: A bright star in the sky contains scientific gold - Helmholtz Zentrum München. Retrieved February 24, 2019 .
  25. ↑ Murchison: Ancient meteorite houses millions of building blocks of life . In: Spiegel Online . February 16, 2010 ( spiegel.de [accessed February 12, 2019]).
personal data
SURNAME Schmitt-Kopplin, Philippe
BRIEF DESCRIPTION scientist
DATE OF BIRTH 20th century