Robert L. Letsinger

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Robert Lewis Letsinger (born July 31, 1921 in Bloomfield , Indiana , † May 26, 2014 in Seattle ) was an American chemist .

Life

Letsinger obtained a Bachelor's degree in 1943 and a Ph.D. in 1945 from Avery Adrian Morton with his thesis A study of the action of organoalkali metal compounds on butadiene. , both at the Massachusetts Institute of Technology in Cambridge , Massachusetts . Since 1946 he has been on the faculty of Northwestern University in Evanston , Illinois , most recently as Clare Hamilton Hall Professor Emeritus .

Letsinger was married to Dorothy Thompson (1922-2010) and the couple had two children.

Act

Oligonucleotide linkage with the phosphoric acid triester method.
MMT = -CPh 2 (4-MeOC 6 H 4 ).

In the 1960s, Letsinger's group developed methods for the solid-phase synthesis of oligonucleotides , including the phosphoric acid triester method and the phosphoramidite synthesis . He thereby laid the foundations for the efficient automated synthesis of gene fragments and thus the rapid development of molecular biology .

Letsinger's later work dealt with nanotechnology and its application in DNA diagnostics. In 2000, Letsinger was a co-founder of the biotechnology company Nanosphere Inc., based in Northbrook , Illinois.

Awards (selection)

Individual evidence

  1. ↑ Robert L. Letsinger, pioneering DNA scientist, dies at 92 ( Memento from June 26, 2015 in the Internet Archive )
  2. ^ Biographical data, publications and academic family tree of Robert Lewis Letsinger at academictree.org, accessed on March 7, 2018.
  3. ↑ Frederick D. Lewis, Robert L. Letsinger, Michael R. Wasielewski: Dynamics of Photoinduced Charge Transfer and Hole Transport in Synthetic DNA Hairpins. In: Acc. Chem. Res., 2001, 34 (2), pp. 159-170 doi: 10.1021 / ar0000197
  4. ↑ Dorothy T. Letsinger at allenfuneralhome.org; Retrieved May 26, 2012
  5. ^ Robert L. Letsinger, Kelvin K. Ogilvie: Nucleotide chemistry. XIII. Synthesis of oligothymidylates via phosphotriester intermediates . In: J. Amer. Chem. Soc. . 91, No. 12, 1969, p. 3350. doi : 10.1021 / ja01040a042 .
  6. ↑ DNA synthesis technology at chemgapedia.de; Retrieved May 26, 2012
  7. ↑ Nanoshpere: About Nanosphere (nanosphere.us); accessed on February 13, 2016
  8. ^ John Simon Guggenheim Foundation - Robert L. Letsinger. In: gf.org. Retrieved February 13, 2016 .
  9. ^ Past Winners - Rosenstiel Award - Rosenstiel Basic Medical Sciences Research Center - Brandeis University. In: brandeis.edu. Retrieved January 23, 2016 .
  10. ↑ Book of Members 1780 – present, Chapter L. (PDF; 1.1 MB) In: American Academy of Arts and Sciences (amacad.org). Accessed May 10, 2019 .
  11. ↑ Arthur C. Cope Scholar Awards at the American Chemical Society (acs.org); accessed on May 10, 2019.
personal data
SURNAME Letsinger, Robert L.
ALTERNATIVE NAMES Letsinger, Robert; Letsinger, Robert Lewis
BRIEF DESCRIPTION American chemist
DATE OF BIRTH July 31, 1921
PLACE OF BIRTH Bloomfield (Indiana)
DATE OF DEATH May 26, 2014
Place of death Seattle